Estimation of the risk factors of the congenital urinary system defects

Łukomska, Agnieszka; Baumert, Małgorzata; Krzych, Łukasz J.; Sypniewska, Kinga

doi:10.2478/s11536-011-0116-z

Cited by 2 publications

(4 citation statements)

References 26 publications

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“…Infections during pregnancy may be expected to be closely related with the intake of certain medications, and this is perhaps this is reflected in the nearly twofold risk of CAKUTs among newborns of mothers reporting infections and use of medications during pregnancy. This risk is similar in magnitude to those reported for antibiotics and antipyretics medications (Abe et al, ; Lukomska et al, ). We refrained from dividing the drugs into pharmacological groups, because most women (12,452 or 31.8%) consumed more than one medication due to pregnancy complications or maternal illness that existed before pregnancy; the most frequently used were dipyridamolum, drotaverinum, and dydrogesteronum.…”

Section: Discussionsupporting

confidence: 85%

“…The significant association of CAKUTs with maternal infections during pregnancy is supported by other studies (Abe et al, ; Lukomska et al, ). These studies differ from the current assessment by limiting the exposure to the first trimester of pregnancy rather than considering the whole pregnancy duration.…”

Section: Discussionsupporting

confidence: 65%

“…This risk is similar in magnitude to those reported for antibiotics and antipyretics medications (Abe et al, 2003;Lukomska et al, 2012). We refrained from dividing the drugs into pharmacological groups, because most women (12 452 or 31.8%) consumed more than one medication due to pregnancy complications or maternal illness that existed prior to pregnancy; the most frequently used were dipyridamolum, drotaverinum and dydrogesteronum.…”

Section: Diagnostic Issuesmentioning

confidence: 75%

See 2 more Smart Citations

Congenital anomalies of the kidney and the urinary tract: A murmansk county birth registry study

Postoev

Grjibovski

Kovalenko

et al. 2016

Birth Defects Research

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 65%

Section: Diagnostic Issuesmentioning

confidence: 75%

See 1 more Smart Citation

Congenital anomalies of the kidney and the urinary tract: A murmansk county birth registry study

Postoev

Grjibovski

Kovalenko

et al. 2016

Birth Defects Research

View full text Add to dashboard Cite

show abstract

“…To diagnose malformations of the kidneys and organs of the urinary system and their complications in children, the results of various laboratory and instrumental research methods, assessment of the rate of diuresis, study of the mother's history with the identification of hereditary factors, and especially the clinical state are taken into account. However, there are a number of limiting factors associated with the physiological characteristics of the urinary system of the newborn, difficulties in using special research methods due to age, as well as the scarcity of clinical manifestations [5].…”

Section: Discussionmentioning

confidence: 99%

Clinical laboratory diagnosis of obstructive megaureter in children

Svekatun

Dmitriakov

Lytvynenko

2020

PPS

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Introduction. Currently, there are more than 200 methods of surgical treatment of a megaureter, but none of the methods has achieved universal acceptance. Until now, the issues of differential diagnosis of organic and functional causes of ureteral dilatation in children under 3 years of age have not been sufficiently illuminated, there is no generally accepted algorithm for the management of patients with this pathology.Relevance. The relevance of obstructive uropathies is evidenced by the fact that they occupy the third position in the list of the most common causes of chronic kidney disease in children, and account for 15% of cases. The prognosis of the outcome of obstructive uropathy is determined by the nature of the lesion and the degree of involvement in the pathological process of the kidneys, one of the main homeostatic and endocrine organs in humans. The degree of involvement of various markers in the development and progression of kidney damage in children is still insufficiently understood. All this prompts the search for screening, highly sensitive and specific methods for the diagnosis and prediction of nephrosclerotic changes in children against the background of urinary tract obstruction. Objective:The study of the clinical and laboratory diagnostic methods, allowing to differentiate functional or organic urodynamic disorders, to determine the tactics of managing patients with obstructive uropathy.12 Materials and methods. Since 2016, a study has been conducted of 174 children aged 0 to 18 years. 3 groups of children were identified: 1) with endoscopic treatment (main group);2) treated with an open surgical method (control group); and 3) a group of children without urinary tract obstruction (reference group). Results.In the course of the study, it was found that the most optimal values of serum cystatin C, close to the reference group (0.048-0.831 mg/ml) were obtained in children treated with endoscopic correction of the intramural ureter (0.217-0.798 mg/ml). Conclusions. The tactics of endoscopic treatment of obstructive uropathies in children has advantages in terms of open surgical methods in technical simplicity, minimally invasiveness, maximum physiology, and a decrease in the frequency of postoperative complications. These theses are confirmed by the obtained results of the study of serum cystatin C as a marker of the state of renal filtration. It should be remembered that the effectiveness of endoscopic stenting of the lower ureter depends on the age of the child.

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Estimation of the risk factors of the congenital urinary system defects

Abstract: Abstract

Cited by 2 publications

References 26 publications

Congenital anomalies of the kidney and the urinary tract: A murmansk county birth registry study

Congenital anomalies of the kidney and the urinary tract: A murmansk county birth registry study

Clinical laboratory diagnosis of obstructive megaureter in children

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