Estimation of the Secretion Rate of Thyrotropin in Man*

Odell, William D.; Utiger, Robert D.; Wilber, John F.; Condliffe, Peter G.

doi:10.1172/jci105601

Cited by 80 publications

(32 citation statements)

References 17 publications

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“…The other 15 patients, judged to be clinically euthyroid, had historical evidence of either thyroid or pituitary disease but had normal levels of TT4, free T4, and TTs, and T3R. These 15 patients were specifically included to provide a greater number of MCR determinations in patients with normal levels of circulating thyroid hormones and included the following: four patients with the empty sella syndrome documented by pneumoencephalography who were taking no therapy; four patients with a hyperfunctioning thyroid nodule, and seven (7,8).…”

Section: Methodsmentioning

confidence: 99%

“…These newer methods have utilized nonequilibrium conditions, highly purified labeled hTSH, higher dilutions of sera, and incubation pf standards in "TSH-free" serum. These methods permit differentiation of hTSH concentrations in normal and hyperthyroid patients and yield lower values for normal serum hTSH than had previously (7,8) been used for calculation of the hTSH PR. Further, the assumption that the 24 h production rate of hTSH remains constant has been supported by studies showing constant blood levels of hTSH during the 24-h period (3,17,18).…”

Section: Methodsmentioning

confidence: 99%

“…In 1962, Bakke, Lawrence, and Roy (6) administered bovine TSH intravenously to euthyroid and hypothyroid patients, determined the half-life of the serum bTSH by bioassay, and estimated production rates of hTSH to be 260 USP mU/day in the former and approximately 2,600 USP mU/day in the latter. In 1967, Odell, Utiger, Wilber, and Condliffe (7) injected ['I]hTSH intravenously as a single bolus in tracer quantities and followed the disappearance of labeled hormone by antibody precipitation. MCR were 42.5 ml/min in euthyroid and 36.3 ml/min in hypothyroid patients.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic Clearance and Production Rates of Human Thyrotropin

Ridgway¹,

Weintraub²,

Maloof³

1974

J. Clin. Invest.

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A B S T R A C T Metabolic clearance (MCR) and production rates (PR) of human thyrotropin (hTSH) were determined by the constant infusion to equilibrium method 57 times in 55 patients. 16 control patients had a mean hTSH MCR of 50.7 ml/min. The mean hTSH MCR was significantly (P < 0.02) higher in 19 euthyroid men (51.6 ml/min) than in 12 euthyroid women (43.0 ml/min), but this apparent sex difference disappeared when the MCR were corrected for surface area, 25.8 (men) versus 25.2 ml/min per m' (women). Hypothyroid patients had significantly (P < 0.005) lower hTSH MCR (30.9 ml/min), and hyperthyroid patients had significantly (P < 0.05) higher hTSH MCR (60.9 ml/min) than controls. The hTSH MCR in patients with "decreased thyroid reserve" (40.9 ml/ min), hyperfunctioning thyroid nodule (53.8 ml/min), and "empty sella syndrome" (46.6 ml/min) were not significantly different from controls. The mean hTSH PR in controls (104.3 mU/day) was significantly (P < 0.005) different from that in patients with "decreased thyroid reserve" (956 mU/day), hypothyroidism (4,440 mU/day), hyperthyroidism (< 43.9 mU/ day) and a hyperfunctioning thyroid nodule (<38.7 mU/day). In primary hypothyroidism intravenous triiodothyronine therapy (50 pg/day) for 10 days decreased the hTSH PR (from 4,244 to 2,461 mU/day) before changes in the hTSH MCR (from 33.1 to 33.7 mU/day) were observed.These studies have demonstrated that changes in the serum concentration of hTSH are mainly due to altered pituitary hTSH secretion with only a minor contribution from the change in hTSH MCR.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metabolic Clearance and Production Rates of Human Thyrotropin

Ridgway¹,

Weintraub²,

Maloof³

1974

J. Clin. Invest.

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“…This study was presented in part at the 57th Annual Meeting of the Endocrine Society, [18][19][20] June 1975, New York.…”

mentioning

confidence: 99%

Metabolic clearance and secretion rates of subunits of human thyrotropin.

Kourides¹,

Ré²,

Weintraub³

et al. 1977

J. Clin. Invest.

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A B S T R A C T Metabolic clearance rates (MCR) ofthe alpha and beta subunits of human thyrotropin (hTSH-a and hTSH-,8) were determined by a constant infusion to equilibrium method. In 15 normal individuals (six men, six premenopausal women, and three postmenopausal women), the mean MCR of hTSH-a (68 ml/min per m2) was significantly faster than that of hTSH-,B (48 ml/min per M2) was significantly faster than that of hTSH-,B (48 ml/min per m2); both were two to three times more rapid than the previously determined MCR of hTSH. In patients with primary hypothyroidism, MCR were significantly slower with a mean value of 55 ml/min per m2 for hTSH-a and 37 ml/min per m2 for hTSH-,B. However, MCR of subunits were not significantly faster than normal in hyperthyroid patients.

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“…Hypothyroidism was associated with increased sialylated pituitary TSH isoforms in the mammalian, including human circulation (15,16). Evidence supports the notion that slower TSH degradation could, at least partly, explain supranormal TSH levels in hypothyroid states (14,17). One could speculate that sorafenib-induced hypothyroidism may be accompanied by changes in TSH carbohydrate structures, i.e.…”

Section: Discussionmentioning

confidence: 77%

Sorafenib therapy decreases the clearance of thyrotropin

Verloop¹,

Smit²,

Dekkers

2013

European Journal of Endocrinology

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Objective: Thyroid function abnormalities are common during treatment with tyrosine kinase inhibitors such as sorafenib. Suggested causes are direct effects on thyroid tissue and increased extrathyroidal metabolism of serum thyroxine and 3,5,3-triiodothyronine. We postulated that tyrosine kinase inhibitors may affect the peripheral metabolism of TSH as well. The effect of sorafenib on TSH clearance was studied. Design: In a study of athyreotic patients on TSH suppression therapy, TSH concentrations were measured after recombinant human TSH (rhTSH) injections before and after 26 weeks of sorafenib therapy. Methods: Before and after the last week of sorafenib therapy, 20 patients with progressive differentiated thyroid carcinoma received a standard dose regimen of two injections 0.9 mg rhTSH on two consecutive days. TSH concentrations were measured 48 h (TSH 48 h ) and 96 h (TSH 96 h ) after the first rhTSH injection. The area under the curve (TSH-AUC), reflecting TSH content between 48 and 96 h following rhTSH administration, was calculated. Results: TSH 48 h levels (120.5 mU/l before vs 146.3 mU/l after; PZ0.029), TSH 96 h levels (22.0 mU/l before vs 35.5 mU/l after; PZ0.001), and TSH-AUC (142.7 vs 186.8 mU/l; PZ0.001) were significantly higher after sorafenib treatment. Higher sorafenib doses were associated with increased changes in TSH 96 h and TSH-AUC. In two patients, TSH levels after sorafenib therapy exceeded 200 mU/l. Conclusions: Sorafenib therapy is accompanied by higher rhTSH levels, probably due to a decreased TSH clearance. Further studies are recommended to clarify whether a decreased clearance of TSH is sorafenib specific.

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Estimation of the Secretion Rate of Thyrotropin in Man*

Cited by 80 publications

References 17 publications

Metabolic Clearance and Production Rates of Human Thyrotropin

Metabolic Clearance and Production Rates of Human Thyrotropin

Metabolic clearance and secretion rates of subunits of human thyrotropin.

Sorafenib therapy decreases the clearance of thyrotropin

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