Estimation of toxicokinetic parameters in population models for inhalation studies with ethylene

Selinski, Silvia; Golka, Klaus; Bolt, Hermann M.; Urfer, Wolfgang

doi:10.1002/1099-095x(200007/08)11:4<479::aid-env434>3.0.co;2-v

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Hazardous Agents

Urfer¹

2006

Encyclopedia of Environmetrics

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Evaluation of hazards associated with exposure to chemicals, understanding of relationships between dose and adverse effect, extrapolation of effects from high experimental doses to low doses associated with actual exposures, and extrapolation from effects observed in animals to effects expected in humans are the main issues of statistical research in risk assessment of hazardous agents. Statistical aspects of inhalation toxicology, proof of hazard, genetic toxicology and the role of oncogenes in carcinogenesis are discussed. Finally, the need for more statistical research to identify hazardous agents by DNA and protein sequence analysis is outlined.

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Hazardous Agents

Urfer¹

2006

Encyclopedia of Environmetrics

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Self-Organizing Maps and its Applications in Sleep Apnea Research and Molecular Genetics

Guimarães

Urfer

2003

Studies in Classification, Data Analysis, and Knowledge Organization

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This paper presents the application of special unsupervised neural networks (self-organizing maps) to different domains, as sleep apnea discovery, protein sequences analysis and tumor classification. An enhancement of the original algorithm, as well as the introduction of several hierachical levels enables the discovery of complex structures as present in this type of applications. Furthermore, an integration of unsupervised neural networks with hidden markov models is proposed.

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Health- and vegetative-based effect screening values for ethylene

Erraguntla

Grant

2015

Chemico-Biological Interactions

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Estimation of toxicokinetic parameters in population models for inhalation studies with ethylene

Cited by 10 publications

References 21 publications

Hazardous Agents

Hazardous Agents

Self-Organizing Maps and its Applications in Sleep Apnea Research and Molecular Genetics

Health- and vegetative-based effect screening values for ethylene

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