Estimation of variance components of local stereological volume estimators: a pilot study

Pawlas, Zbyněk; Nyengaard, Jens Randel

doi:10.1111/j.1365-2818.2009.03206.x

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…For populations of neurons with similar sizes and close-to-spherical shapes, estimating the size of as few as 25 cells may provide satisfactory information regarding the size distribution of the population. Significantly higher numbers are required for populations in which the objects have very variable sizes and complex shapes (Pawlas and Nyengaard 2009). As a starting point for studies of this kind, it is suggested that the volume of 100-150 objects be estimated in each individual.…”

Section: Box 1 Size-weighted Samples Of Objectsmentioning

confidence: 99%

Local Estimators of Size in Stereological Studies

West¹

2013

Cold Spring Harb Protoc

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There are two general categories of stereological methods, global and local. Global stereological estimators include estimators of total volume, surface, length, and number. Local estimators can be used to estimate the volumes or surfaces of single objects and, thereby, the distribution of object sizes or the mean size of objects within a population. Two local estimators that have proved to be of practical value for measuring the volume of cells in neurobiological studies are the nucleator and the rotator, which are the focus of this article. Variants of the nucleator can be used for estimating object number, object surface, and the spatial distributions of objects.

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Section: Box 1 Size-weighted Samples Of Objectsmentioning

confidence: 99%

Local Estimators of Size in Stereological Studies

West¹

2013

Cold Spring Harb Protoc

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“…The case of interacting particles will be considered in a future article, cf. Pawlas and Nyengaard (2007).…”

Section: Local Sampling and Local Estimation Of Particle Sizesmentioning

confidence: 99%

Particle Sizes from Sectional Data

Pawlas¹,

Nyengaard²,

Jensen³

2009

Biometrics

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We propose a new statistical method for obtaining information about particle size distributions from sectional data without specific assumptions about particle shape. The method utilizes recent advances in local stereology. We show how to estimate separately from sectional data the variance due to the local stereological estimation procedure and the variance due to the variability of particle sizes in the population. Methods for judging the difference between the distribution of estimated particle sizes and the distribution of true particle sizes are also provided.

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Estimation of variance components of local stereological volume estimators: a pilot study

Cited by 2 publications

References 13 publications

Local Estimators of Size in Stereological Studies

Local Estimators of Size in Stereological Studies

Particle Sizes from Sectional Data

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