Estimation of vessel age and early diagnose of atherosclerosis in progeria syndrome by using echo-tracking

Várady, Edit; Fehér, Eszter; Lévai, András; Bíró, István

doi:10.3233/ch-2010-1279

Cited by 4 publications

(4 citation statements)

References 13 publications

(10 reference statements)

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“…When motion is usually carried out at the standard time and frequency on no uniform, generally patients feel no fatigue tolerance to [8] . Through appropriate intensity aerobic exercise can effectively improve the patient's bone density at the same time within a certain range, the longer the time of patient motion, the higher the frequency the greater the stimulation of bone stress can effectively maintain and improve the content of bone mineral density.…”

Section: Discussionmentioning

confidence: 99%

Research on incremental load power bicycle exercise on bone mineral density in patients with osteoporosis

Liu¹,

Yan²

2016

Proceedings of the 2016 6th International Conference on Machinery, Materials, Environment, Biotechnology and Computer

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Objective to explore the effect of incremental cycle ergometer exercise on bone mineral density in patients with osteoporosis. Methods 60 cases with osteoporosis in 2013 January-2014 year in January in our hospital as the research object, according to the different treatment as control group and observation group, the control group was given conventional bicycle exercise therapy, the observation group incremental cycle ergometer exercise therapy, compared two groups of bone mineral density and bone metabolism in patients with the situation. Results in the observation group after treatment, L1-L4 BMD (1.23+0.03)g/cm2, left femoral neck BMD (1.01+0.02)g/cm2, significantly better than the control group (1.13+0.01) g/cm2, (0.94+0.01)g/cm2, the difference was statistically significant P<0.01. The observation group after treatment of hip bone mineral density is (0.70+0.17)g/cm2, the bone density of the lumbar spine is (0.95+0.28)g/cm2, significantly better than the control group (0.62+0.12)g/cm2, (0.84+0.10)g/cm2, the difference was statistically significant P<0.05. Conclusion the clinical effect of incremental cycle ergometer exercise in treating senile osteoporosis significantly, can effectively promote the bone mineral density and bone absorption of patients, has good effect on prevention of patients with fracture.

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Section: Discussionmentioning

confidence: 99%

Research on incremental load power bicycle exercise on bone mineral density in patients with osteoporosis

Liu¹,

Yan²

2016

Proceedings of the 2016 6th International Conference on Machinery, Materials, Environment, Biotechnology and Computer

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“…Therefore, ET technology can predict AS in CSF patients early and noninvasively. In addition, other diseases that affect arterial elasticity, such as Hutchinson-Gilford progeria syndrome [16], uremia [17], hyperuricemia [18], have been studied due to the popularity of ET technology, and satisfactory results have been obtained.…”

Section: Echo Tracking (Et) Techniquementioning

confidence: 99%

Application and Progress of Ultrasound Technology in Atherosclerosis

Gong¹,

Xue²

2023

Advanced Ultrasound in Diagnosis and Therapy

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Atherosclerosis (AS) is the main pathophysiological process behind CVD. Cardiovascular diseases caused by AS (such as stroke, coronary heart disease, etc.) are characterized by a high prevalence, high disability rate and high mortality, which greatly increase the burden on families and society. Thus, it is important to find AS as early as possible. When atherosclerosis occurs, the earliest sign of its structural and functional changes is arterial stiffness, and endothelial dysfunction is the key link.Arteriosclerosis is caused by the imbalance between collagen and elastin in the arteries. Elastin fibers gradually decrease, and stiffer collagen fibers increase, making the vessels less elastic. Endothelial dysfunction also affects the regulatory function of arterial vascular tension, and accelerates the remodeling of the vascular wall, to make blood vessels more rigid. Quantitative measurement of arterial stiffness and carotid intima-media thickness (CIMT) is an important tool for early detection of vascular lesions. At present, ultrasound technology including echo tracking (ET), wave intensity (WI), real-time shear wave elastography (SWE), ultrafast pulse wave velocity (ufPWV), shear wave dispersion (SWD), cardio-ankle vascular index (CAVI), arterial velocity pulse index and arterial pressure volume index (AVI and API) has the advantages of being noninvasive, realtime, economical and reproducible in the assessment of atherosclerosis, and is widely used in the early diagnosis of AS. Most importantly, the change in arterial hardness detected by traditional ultrasound technology precedes the change in intima-media thickness, suggesting that ultrasonic elasticity monitoring may be a more sensitive method of predicting AS and can find and prevent cardiovascular diseases earlier.

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“…One of the first steps in atherosclerosis development is endothelial dysfunction, which is a state characterized by decreased arterial responsiveness to stimuli and increased arterial stiffness. Age and smoking, 2 risk factors for cardiovascular diseases, are associated with arterial stiffness [ 1 , 2 ]. Previous studies in humans showed that arterial stiffness could be beneficial for predicting the risk of cardiovascular diseases [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…ET follows the phase shift in ultrasound frequency generated by vessel wall motion during the cardiac cycle, and automatically calculates indicators of arterial stiffness, such as stiffness parameter α, stiffness parameter β, arterial compliance (AC), distensibility coefficient (DC), and one-point pulse wave velocity (PWVβ). Previous studies have used ET to evaluate arterial function in patients with diabetes [ 8 – 10 ], hypertension [ 11 ], cardiovascular disease [ 12 ], Grave’s disease [ 13 ], and progeria [ 1 ] in patients receiving hemodialysis [ 14 ], in smoking individuals [ 2 ], and in normal individuals [ 15 ]; ET can also be used in animals. [ 16 ]…”

Section: Introductionmentioning

confidence: 99%

Correlation between Echo-Tracking Parameters and In Vitro Measurements of Arterial Contraction and Relaxation in Rats Fed a High-Cholesterol Diet

Zeng

Zhan

et al. 2015

Med Sci Monit

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BackgroundEcho-tracking (ET) is a new technique that allows the assessment of arterial function and stiffness. This study aimed to ascertain the utility of the echo-tracking (ET) technique to assess vascular stiffness in rats with hypercholesterolemia and atherosclerosis.Material/MethodsET was used to measure the arterial stiffness of the aorta in cholesterol-fed Sprague-Dawley rats (group T1, n=10, for 4 weeks; group T2, n=10, for 12 weeks) and normal control rats (group C1, n=10; group C2, n=10). In vitro isometric tension experiments were used to measure the maximum contractile tension (MCT) and maximum relaxation percentage (MRR%) of aortic rings. Indicators of arterial stiffness and aortic MCT and MRR% were compared between groups using linear regression analysis. Light microscopic evaluation was used to demonstrate atherosclerotic changes in the aorta.ResultsThe rat models were successfully induced; pathological examination of the aortas showed significant atherosclerosis in group T2, but not in groups C1, C2, or T1. The arterial stiffness parameters obtained using ET and aortic rings in vitro showed significant impairments in T1 and T2 rats compared with C1 and C2 controls (all P<0.05 vs. controls). In addition, these impairments were greater in the T2 group than in the T1 group (all P<0.05). Finally, MRR% correlated with the distensibility coefficient (r=0.396, P=0.012), arterial compliance (r=0.317, P=0.047), stiffness parameter β (r=−0.406, P=0.009) and one-point pulse wave β (r=−0.434, P=0.005).ConclusionsThese results suggest that ET could be used to evaluate the changes in arterial wall elasticity associated with atherosclerosis and hypercholesterolemia.

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Estimation of vessel age and early diagnose of atherosclerosis in progeria syndrome by using echo-tracking

Cited by 4 publications

References 13 publications

Research on incremental load power bicycle exercise on bone mineral density in patients with osteoporosis

Research on incremental load power bicycle exercise on bone mineral density in patients with osteoporosis

Application and Progress of Ultrasound Technology in Atherosclerosis

Correlation between Echo-Tracking Parameters and In Vitro Measurements of Arterial Contraction and Relaxation in Rats Fed a High-Cholesterol Diet

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