Estimation the protective role of Andrographis paniculata aqueous extracts on nephrotoxicity in male rabbits treated with butylated hydroxytoluene (BHT)

Abstract

This study is aimed at knowing the protective role of aqueous extract of Andrographis paniculata on the toxic effects induced by butylated hydroxytoluene (BHT) in domestic male rabbits. The study was conducted in College of Education for Pure Sciences / Univ. of Karbala from November 2021 until February 2022. Forty adult male rabbits have been used, which were divided randomly into four equal groups (10animals/group), the first group(G1) was administered with 1ml/kg of corn oil and considered to be the control group. The second group (G2) administrated 1mg/kg of the BHT, the third group (G3) had administrated 100mg/kg of A. paniculata, whereas animals of 4th group (G4) administrated 1mg/kg of the BHT and 100mg/kg of A. paniculata extract orally for a month daily. Fasting Blood samples were collected after the end of the experimentation for the purpose of studying the concentration of the following parameters: Albumin, Urea, Uric acid, superoxide dismutase (SOD), Reduced Glutathione (GSH) and Malondialdehyde (MDA). The results showed that oral administration of BHT caused a significant increase (P<0.01) in concentrations of Urea, Uric acid, and MDA, while there was a significant reduction (P<0.01) in concentration of Albumin and GSH in comparison with the control group.