Estimation the Role of CD4 and CD8 in patients infected with Varicella-Zoster Virus in Al-Najaf Al-Ashraf City

Abstract

About 60 samples were collected from patients with varicella zoster, including 24 males and 36 females, as well as from healthy people, which included 29 samples (15 males and 14 females), aged between 15 and 60 years. Data were collected in the holy city of Najaf between November, 2022 and July, 2023. VZV patients were selected from Sadr Medical City and private laboratories. The research used BD FACS Canto II Flow Cytometry technology to measure the CD4 and CD8 cells/ml in the blood of patients and healthy controls. The majority of patients fell within the age groups of 26–34 and 36–45, constituting approximately 25%, with a mean standard deviation of 37.17 ± 12.38. Conversely, the control group mostly belonged to the age group of 25 years and above, representing about 34.48%, with a mean and standard deviation of 26.86 ± 4.74. The results revealed that patients with VZV exhibited a significantly decrease of CD4 count (303.7833 ± 64.276) compared to the control group (626.103 ± 122.07) (p-value < 0.0001). Patients with Varicella-Zoster Virus (VZV) showed a significant increase in CD8 count (1197.717 ± 201.369) compared to the control group (580.379 ± 98.391) with a p-value ≤ 0.0001.