Estimations of the number people with mental diseases associated with toxoplasmosis and identification of risk factors by continent

Nessim, Jennifer; Luna-Ramirez, Julio Cesar; Moreno-Gómez, Germán Alberto; Galvis-Soto, Diana Milena; Gómez-Marín, Jorge Enrique

doi:10.1016/j.psychres.2023.115130

Cited by 12 publications

(9 citation statements)

References 69 publications

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“…Recent studies highlighted the potential correlation between chronic T. gondii infection and psychiatric disorders [ 38 , 39 ]. This association may be underpinned by various mechanisms through which T. gondii exerts its influence on the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Toxoplasma gondii IgG Antibodies and Associated Risk Factors in Psychiatric Patients from Western Romania: A Cross-Sectional Study

Grada,

Mihu,

Oatis

et al. 2024

Microorganisms

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Infection with the coccidian parasite Toxoplasma gondii was associated with an increased risk of several mental disorders. We conducted a case–control study of 464 consecutive psychiatric patients and assessed the prevalence of IgG antibodies against T. gondii and the potential risk factors associated with infection. T. gondii-specific antibodies were determined using a chemiluminescence assay. A questionnaire was utilized to assess the potential correlation between risk factors and Toxoplasma gondii seropositivity. IgG antibodies were found in 325 (70.04%) of the patients. We observed a higher likelihood of positive IgG antibodies against Toxoplasma gondii in older individuals, patients residing in rural areas, and females. We also noted associations between Toxoplasma gondii infection and certain risk factors, like activities that involve contact with soil, low-income levels, and limited educational attainment. Our findings indicate a high prevalence of T. gondii infection among psychiatric patients from Western Romania and provide new information regarding the potential risk factors associated with T. gondii in this population group. This study may serve as a foundation for future research and the development of preventive strategies.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Toxoplasma gondii IgG Antibodies and Associated Risk Factors in Psychiatric Patients from Western Romania: A Cross-Sectional Study

Grada,

Mihu,

Oatis

et al. 2024

Microorganisms

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“…Also, another study done in 2023, a meta-analysis has provided compelling evidence linking toxoplasmosis to some psychiatric conditions, including suicidal thoughts and behaviors, bipolar disorder, and schizophrenia. Here, we calculate the number of instances based on the portion of these illnesses that may be attributed to toxoplasmosis [47]. Numerous observational studies found a moderate to strong correlation between SCZ and toxoplasmosis.…”

Section: Relation Between Toxoplasmosis and Schizophreniamentioning

confidence: 99%

Association Between Latent Toxoplasmosis and Schizophrenia

Ismael,

Naamaan,

Abdullah

2024

ejmhr

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Toxoplasma gondii, a protozoan parasite, is known to establish a lifelong latent infection in humans. This infection, termed latent toxoplasmosis, has been implicated in various neurological and psychiatric disorders, including schizophrenia. Schizophrenia is a complex psychiatric disorder characterized by disruptions in thought processes, perceptions, and social behavior. While its exact etiology remains elusive, studies have increasingly explored the potential role of infectious agents in its development and progression. Epidemiological studies have shown an association between toxoplasma infection and an increased risk of schizophrenia development. Moreover, several plausible pathways have been proposed through which Toxoplasmosis may exert its influence on the central nervous system, including alterations in neurotransmitter levels, immune response dysregulation, and neuroinflammation. Understanding the intricate relationship between latent toxoplasmosis and schizophrenia could pave the way for novel therapeutic interventions and preventive strategies for individuals at risk. This review aims to consolidate current knowledge regarding the relationship between latent toxoplasmosis and schizophrenia. It synthesizes findings from epidemiological studies, clinical observations, and experimental research investigating the prevalence of toxoplasmosis in individuals with schizophrenia compared to the general population. Additionally, it examines the potential mechanisms through which T. gondii infection might contribute to the pathogenesis of schizophrenia, including neuroimmune responses, neurotransmitter alterations, and neurodevelopmental effects.

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“…Nessim et al mencionan que el porcentaje de población asociada a seropositividad a T. gondii y esquizofrenia es de 20,4 %, trastorno bipolar 27,3 % y conductas suicidas de un 0,29 %, dichos porcentajes están sujetos a variaciones por área geográfica debido a los factores de riesgo prevalentes regionalmente. Por ejemplo, los factores de riesgo de toxoplasmosis asociados a enfermedades mentales fueron: en África, la contaminación del agua; y, en la región Europea, las condiciones de cocción de las carnes 15 .…”

Section: Trastornos Psiquiátricos Asociados a La Infección Latente Co...unclassified

Seroprevalencia de Toxoplasma gondii y su relación con trastornos mentales en adultos

Lemus Buitrago,

Osegueda Ascencio,

Fuentes Rodríguez

2024

Alerta (San Salvador)

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El Toxoplasma gondii es un parásito que se encuentra, aproximadamente, en el 30 % de la población humana. Durante los últimos años se ha evidenciado que la infección latente puede ser un factor de riesgo para el desarrollo de trastornos mentales; particularmente para la esquizofrenia, ansiedad, trastornos bipolares y trastornos de conducta. La asociación con los trastornos neuropsiquiátricos pueden explicarse por la influencia que tiene el parásito sobre la expresión de múltiples neurotransmisores; entre ellos la dopamina. Se realizó una búsqueda en las bases de datos PubMed y SciELO de 2015 a 2023, se seleccionaron artículos originales y de revisión de revistas científicas internacionales, en idiomas inglés y español con el objetivo de describir la relación entre la seroprevalencia de T. gondii y el desarrollo de trastornos mentales en población adulta. Existe relación entre los trastornos mentales en la población adulta con la infección por Toxoplasma gondii y este aumenta la posibilidad de desarrollar esquizofrenia y depresión en individuos sin historial previo, y que podría exacerbar cuadros psiquiátricos previos con dificultad en el tratamiento. Sin embargo, no todos los datos estadísticos establecen una relación directa, algunos estudios demuestran una asociación, ciertos datos son discordantes, lo que abre una puerta para futuras investigaciones.

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Estimations of the number people with mental diseases associated with toxoplasmosis and identification of risk factors by continent

Cited by 12 publications

References 69 publications

Prevalence of Toxoplasma gondii IgG Antibodies and Associated Risk Factors in Psychiatric Patients from Western Romania: A Cross-Sectional Study

Prevalence of Toxoplasma gondii IgG Antibodies and Associated Risk Factors in Psychiatric Patients from Western Romania: A Cross-Sectional Study

Association Between Latent Toxoplasmosis and Schizophrenia

Seroprevalencia de Toxoplasma gondii y su relación con trastornos mentales en adultos

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