Estradiol administration modulates neural emotion regulation

Rehbein, Elisa; Kogler, Lydia; Hornung, Jonas; Morawetz, Carmen; Bayer, Janine; Krylova, Marina; Sundström‐Poromaa, Inger; Derntl, Birgit

doi:10.1016/j.psyneuen.2021.105425

Cited by 26 publications

(5 citation statements)

References 53 publications

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“…However, the main adaptive problem sex hormones solved was facilitating sexual reproduction. This reasoning applies to many of Benenson et al's other proposed female selfprotection adaptations that are influenced by hormones, including immune function, fear, stress, autoimmune disorders, responses to vaccines, depression, anxiety, and emotion recognition (Amiaz & Seidman, 2008;Dirlikov, Lavoie, & Shem, 2019;Glover et al, 2013;Hermans, Putman, Baas, Koppeschaar, & van Honk, 2006;Maeng & Milad, 2015;Rehbein et al, 2021;Rosen, Ham, & Mogil, 2017;Ruggieri, Anticoli, D'Ambrosio, Giordani, & Viora, 2016). Underlying continuous factors might also explain responses to some social threats.…”

Section: Discussionmentioning

confidence: 92%

The pregnancy compensation hypothesis, not the staying alive theory, accounts for disparate autoimmune functioning of women around the world

Kunz

Goodnight²,

Wilson³

2022

Behav Brain Sci

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Section: Discussionmentioning

confidence: 92%

The pregnancy compensation hypothesis, not the staying alive theory, accounts for disparate autoimmune functioning of women around the world

Kunz

Goodnight²,

Wilson³

2022

Behav Brain Sci

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“…Researchers have shown that the changes in women's menstrual cycles are reflected not only in physiology, e.g., regular fluctuation of hormone secretion, but also in psychopathological symptoms, such as pain, anxiety, sadness, and fear 32,33 . Interactions have also been found between sex hormone levels and emotion regulation involving the activity of frontal cortex 34 . In the present study, our results imply that physiological or psychological changes may have some impact on neural regulation at targeted mentioned clusters, with central processing of pain catastrophizing being provoked and increased to a higher level during the menstrual phase of the cycle.…”

Section: Discussionmentioning

confidence: 99%

The reinforced pain catastrophizing and its neural association with chronic menstrual pain

Shang,

Liu,

et al. 2024

Preprint

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Pain catastrophizing is a prominent psychological factor that exhibits a robust correlation with pain. Although the complex property of pain catastrophizing was reported to vary across different pain phases, the contribution of chronic pain in its progression from general trait to a higher state remains unclear. The objective of this study is to examine the neural mechanism and degree to which pain catastrophizing is reinforced in the context of primary dysmenorrhea (PDM), which is one of the most prevalent gynecological complaints experienced by reproductive women. 29 women with moderate to severe PDM were included in this study. Arterial spin labeling was utilized to quantify the cerebral blood flow (CBF) for each subject in both pain-free and painful phases. The pain catastrophizing scale (PCS) was completed in two phases and the Short-Formed McGill Pain Questionnaire was completed in the painful phase. Compared to the pain catastrophizing in pain-free phase (PCS), the pain catastrophizing in the painful phase (PCS) is higher and positively correlated with the compositive factor of menstrual pain. CBF analysis indicates the PCS is positively associated with the CBF of frontal cortex, hippocampus and amygdala. The reinforcement of pain catastrophizing is correlated with the CBF of prefrontal cortex. Specifically, the medial prefrontal cortex, which correlates with pain state as well, plays a crucial role in mediating the reinforcing effect of pain on PCS. These results promote both the phenomenological and mechanical comprehension regarding pain catastrophizing management in individuals with chronic pain.

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“…For instance, MFG RSFC has been linked to the severity of mood problems in women suffering from premenstrual syndrome (PMS) [46]. Furthermore, in healthy women, MFG/IFG activity also appears to be modulated by sex hormones in terms of emotion regulation of negative affect [47] and face processing [48]. The hippocampus, on the other hand, is thought to play an important role in incorporating cognition (e.g., mentalizing) into emotional processing, for example in the case of social emotions [49,50].…”

Section: Discussionmentioning

confidence: 99%

To start or to discontinue the pill – changes in progestogens reflected by resting-state connectivity and positive mood

Kimmig

Friedrich

Drotleff

et al. 2022

Preprint

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Oral contraceptive (OC) intake has been associated with alterations in functional brain architecture and socio-affective processes. However, most previous studies have been limited by cross-sectional designs and/or did not account for synthetic sex hormone concentrations. The aim of this longitudinal study was to determine the effects of starting vs discontinuing OCs on socio-affective functions such as mood and emotion cognition, and to identify their possible neuroendocrinological substrates. To this end, 88 young healthy women performed the behavioral and fMRI measures twice, three to eight months apart: 26 natural cycling women twice during menstruation, 26 OC users twice during OC intake, 25 OC discontinuers and 11 OC starters before and after discontinuation or start, respectively. In addition to mean-based analyses, we used intersubject representational similarity analyses to determine relationships between interindividual variability in within-subject changes of hormone profiles, including concentrations of endogenous and synthetic hormones, region-specific resting state functional connectivity (parcelwise RSFC) and socio-affective measures. Across the whole sample, interindividual patterns of changes in RSFC of fronto-parietal regions, parts of the left hippocampus and the right cerebellum reflected change patterns of progestogen levels. For the right superior orbitofrontal gyrus (OFG), a trinity of idiosyncratic patterns was found in changes of progestogens, RSFC and positive mood. Active OC intake was associated with higher self-reported depressive symptoms in OC discontinuers (and starters). Emotion recognition performance was not associated with changes in hormone profiles or RSFC. Overall, progestogens rather than estrogens appear to be associated with functional brain architecture of the frontal and subcortical/cerebellar regions and positive mood. The right superior OFG represents a possible neural substrate for progestogen-induced changes in positive mood. This study indicates the importance of a multidimensional, longitudinal approach when being interested in effects of hormonal contraception on women's brain and behavior.

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Estradiol administration modulates neural emotion regulation

Cited by 26 publications

References 53 publications

The pregnancy compensation hypothesis, not the staying alive theory, accounts for disparate autoimmune functioning of women around the world

The pregnancy compensation hypothesis, not the staying alive theory, accounts for disparate autoimmune functioning of women around the world

The reinforced pain catastrophizing and its neural association with chronic menstrual pain

To start or to discontinue the pill – changes in progestogens reflected by resting-state connectivity and positive mood

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