Estradiol administration suppresses body temperature elevation induced by application of menthol to ovariectomized rats

Uchida, Yuzo; Atsumi, Koyuki; Hirano, Shinji; Koyanagi, Nao

doi:10.1016/j.jtherbio.2018.10.016

Cited by 8 publications

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References 24 publications

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“…The higher the plasma triglyceride was, the higher the hie-sho score was only in the pre-menopausal group. According to the results that E 2 facilitated thermoregulatory behavior in the cold in ovariectomized rats [23], the subjects in the premenopausal group that had higher E 2 concentration would be more sensitive to thermal unpleasantness in the cold. In addition, the plasma triglyceride and noradrenaline-induced vasoconstriction of mesenteric arteries in the rats fed a highly palatable diet for 15 weeks was higher than that in rats fed a standard chow [24].…”

Section: Discussionmentioning

confidence: 99%

Correlations between “hie-sho” interview score and progesterone, fat intake, and Kupperman index in pre- and post-menopausal women: a pilot study

et al. 2019

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Japanese menopausal women who feel cold, even in a warm room, are said to be experiencing "hie-sho." We assessed the magnitude of coldness by a "hie-sho" interview score. The association between the magnitude of coldness and female hormones, fat intake, and menopausal symptoms is unknown. The aim of the present study was to elucidate the relationship between the hie-sho interview scores and female hormones, fat intake, Kupperman index in pre-(pre group) and post-(post group) menopausal women. The hie-sho interview scores, Kupperman index questionnaire results, dietary survey to analyze fat intake, and body weight were analyzed, and plasma estradiol, progesterone, and lipid levels were measured in the subjects in the pre (n = 9) and post (n = 11) groups. Plasma female hormones and fat intake were different, but the total Kupperman index was not different between pre and post groups. Plasma progesterone was positively correlated with the hie-sho score only in the post group. Plasma triglyceride was positively correlated with the hie-sho score only in the pre group. Intake of cholesterol, arachidonic acid, and docosapentaenoic acid was negatively correlated with the hie-sho score only in the pre group. The positive correlation between total Kupperman index and hie-sho score was observed only in the pre group. These results indicated that progesterone level was related to coldness in post-menopausal women. Fat intake, plasma triglyceride, and menopausal symptoms may be related to coldness in pre-menopausal women.

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Section: Discussionmentioning

confidence: 99%

Correlations between “hie-sho” interview score and progesterone, fat intake, and Kupperman index in pre- and post-menopausal women: a pilot study

et al. 2019

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“…After ovariectomy, a silastic tube with 22.3 mg 17b-estradiol (E2(1)) or not (E2(2)) was placed underneath the right dorsal skin. The details of the surgery and method of E2 administration followed the previous study (4,8).…”

Section: Methodsmentioning

confidence: 99%

“…TRPM8 mRNA expression in ovariectomized rats administered with E2 (5 mg/kg/d, 4 wk) subcutaneously had a tendency to decrease (5); however, the study did not perform menthol application and did not assess TRPM8 mRNA expression in sensory neurons on the skin. In addition, the administration method of E2 was different from that in our previous study (4). Thus, in the present study, we investigated TRPM8 mRNA expression in the spinal ganglia, which are areas that produce TRPM8 mRNA in sensory neurons, in the ovariectomized rats administrated E2 with menthol application in the same manner as our previous study (4).…”

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confidence: 93%

“…In addition, the administration method of E2 was different from that in our previous study (4). Thus, in the present study, we investigated TRPM8 mRNA expression in the spinal ganglia, which are areas that produce TRPM8 mRNA in sensory neurons, in the ovariectomized rats administrated E2 with menthol application in the same manner as our previous study (4).…”

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confidence: 93%

“…E2 suppressed hyperthermia induced by menthol, a TRPM8 agonist and ingredients in mint, in ovariectomized rats. However, E2 did not affect the tail skin temperature and neural activity, according to the assessment by c-Fos immunohistochemistry of the medial preoptic area, which is the thermoregulatory center; and the median preoptic area, paraventricular nucleus, posterior nucleus, and dorsomedial hypothalamus, which are involved in thermogenesis after menthol application (4). The results suggested that the heat dissipation from the tail and the neural activity of the nuclei did not influence the inhibition of menthol-induced hyperthermia by E2.…”

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confidence: 95%

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UCP1 and TRPM8 Expression in the Brown Fat Did Not Affect the Restriction of Menthol-Induced Hyperthermia by Estradiol in Ovariectomized Rats

Uchida

Sato

Atsumi

et al. 2021

J Nutr Sci Vitaminol

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Estradiol (E2) modulates the central and peripheral thermoregulatory responses to cold. Menthol is an agonist of transient receptor potential melastatin type 8 (TRPM8), which is a peripheral cold receptor. E2 suppresses menthol-induced elevation of body temperature (Tb) in ovariectomized rats, but the mechanism is unknown. The aim of the present study is to investigate the effect of E2 on uncoupling protein 1 (UCP1), a thermogenic gene, and TRPM8 mRNA levels in ovariectomized rats applied menthol. A silastic tube was implanted in ovariectomized rats with and without E2 underneath the dorsal skin (E2(1) and E2(2) groups), and data loggers for Tb measurement into peritoneal cavity. After application of 10% l-menthol or vehicle to the skin of the whole trunk of rats, Tb was measured for 2 h. The interscapular brown adipose tissue (BAT) and spinal ganglia of cervical, thoracic, and lumbar parts were obtained for RT-qPCR assay. In the menthol application, Tb in the E2(1) group was lower than that in the E2(2) group. The UCP1 mRNA in the BAT, TRPM8 mRNA in the BAT and spinal ganglia in all areas did not differ between the E2(1) and E2(2) groups. In conclusion, the UCP1 and TRPM8 expression in the brown fat did not affect the restriction of the menthol-induced hyperthermia by estradiol in ovariectomized rats.

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Cinnamaldehyde application decreases tail temperature in ovariectomized rats with and without estradiol administration

Uchida

Atsumi

2019

Journal of Thermal Biology

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Estradiol administration suppresses body temperature elevation induced by application of menthol to ovariectomized rats

Cited by 8 publications

References 24 publications

Correlations between “hie-sho” interview score and progesterone, fat intake, and Kupperman index in pre- and post-menopausal women: a pilot study

Correlations between “hie-sho” interview score and progesterone, fat intake, and Kupperman index in pre- and post-menopausal women: a pilot study

UCP1 and TRPM8 Expression in the Brown Fat Did Not Affect the Restriction of Menthol-Induced Hyperthermia by Estradiol in Ovariectomized Rats

Cinnamaldehyde application decreases tail temperature in ovariectomized rats with and without estradiol administration

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