Estradiol and tamoxifen differently affects the inhibitory effects of vitamin A and their metabolites on the proliferation and expression of α2β1 integrins in MCF-7 breast cancer cells

Czeczuga-Semeniuk, Ewa; Lemancewicz, Dorota; Wołczyński, S

doi:10.2478/v10039-009-0021-8

Cited by 6 publications

(7 citation statements)

References 33 publications

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“…It seems that TYST cells were more sensitive to ATRA which had significantly inhibitory effects on cell proliferation in the concentrations of 10 -7 M at 48 hours and 10 -6 M at 24 hours, as compared with other cells, e.g. peripheral blood mononuclear cells and CD4+ T cells (>10 -4 M [39]), human A375 melanoma cells (>10 -5 M [40]), breast cancer cells (> > 10 -5 M [41]), or small intestinal epithelium (>10 -5 M [42]). The further study is needed to confirm the variation of drug sensitivity between different tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor

et al. 2012

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The testicular yolk sac tumor (TYST) is the most common neoplasm originated from germ cells differentiated abnormally, a major part of pediatric malignant testicular tumors. The present study aimed at developing and validating the in vitro and vivo models of TYST and evaluating the sensitivity of TYST to treatments, by cloning human TYST cells and investigating the histology, ultra-structure, growth kinetics and expression of specific proteins of cloned cells. We found biological characteristics of cloned TYST cells were similar to the yolk sac tumor and differentiated from the columnar to glandular-like or goblet cells-like cells. Chromosomes for tumor identification in each passage met nature of the primary tumor. TYST cells were more sensitive to all-trans-retinoic acid which had significantly inhibitory effects on cell proliferation. Cisplatin induced apoptosis of TYST cells through the activation of p53 expression and down-regulation of Bcl- expression. Thus, we believe that cloned TYST cells and the animal model developed here are useful to understand the molecular mechanism of TYST cells and develop potential therapies for human TYST.

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Section: Discussionmentioning

confidence: 99%

Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor

et al. 2012

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“…Cells in the control group were treated with distilled water, while those in the experimental group were treated with EVs at 10 ng/mL, 100 ng/mL, and 1 μg/mL concentrations for 72 h. S. aureus EVs (1 μg/mL) were used in co-treatment experiments with tamoxifen. Cells were treated with 1 μg/mL S. aureus EVs, 10 μM tamoxifen, or 10 μM tamoxifen plus 1 μg/mL S. aureus EVs for 72 h [ 31 , 32 ]. A trypan blue viability assay was performed to measure relative cell viability.…”

Section: Methodsmentioning

confidence: 99%

Staphylococcus aureus-Derived Extracellular Vesicles Enhance the Efficacy of Endocrine Therapy in Breast Cancer Cells

Kwon

Lim

et al. 2022

JCM

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The microbiome involved in the human estrogen metabolism is known as the estrobolome. This study aimed to show that the estrobolome can be used in breast cancer treatment. We first analyzed the blood microbiome composition of healthy controls and patients with breast cancer. In particular, we investigated the bacteria producing β−glucuronidase and/or β−galactosidase, which are involved in estrogen metabolism in the human body. Staphylococcus species were more abundant in healthy controls than in breast cancer patients and therefore were selected for further analyses. The effect of Staphylococcus aureus on endocrine therapy was analyzed by a combination treatment with tamoxifen. Analysis of the microbiome of blood samples showed that species producing β−glucuronidase were more abundant in breast cancer patients than in healthy controls. Further experiments confirmed that the efficacy of tamoxifen increased when administered in conjugation with the extracellular vesicles (EVs) of S. aureus. Based on our results, we deduced that S. aureus EVs could potentially be used as adjuvants for breast cancer treatment in the future.

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“…In fact, it was demonstrated that the combination of RA with tamoxifen (TAM) or its active metabolite OHTAM exhibit an additive/synergism of action in breast cancer cells [64][65][66][67][68]. Moreover, TAM also enhances inhibitory effect of RA on a2b1 integrin expression in MCF-7 cells [67].…”

Section: The Retinoid-antiestrogen Combined Effects and Their Therapementioning

confidence: 98%

“…Moreover, TAM also enhances inhibitory effect of RA on a2b1 integrin expression in MCF-7 cells [67]. The increase in TGFa production promoted by estradiol is thought to be involved in the stimulation of breast cancer cell proliferation and RA significantly decreases estradiol-induced TGFa synthesis and secretion [55].…”

Section: The Retinoid-antiestrogen Combined Effects and Their Therapementioning

confidence: 99%

Interplay between estrogen and retinoid signaling in breast cancer – Current and future perspectives

Ribeiro¹,

Santos²,

Custódio³

2014

Cancer Letters

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Estradiol and tamoxifen differently affects the inhibitory effects of vitamin A and their metabolites on the proliferation and expression of α2β1 integrins in MCF-7 breast cancer cells

Cited by 6 publications

References 33 publications

Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor

Evaluation of cloned cells, animal model, and ATRA sensitivity of human testicular yolk sac tumor

Staphylococcus aureus-Derived Extracellular Vesicles Enhance the Efficacy of Endocrine Therapy in Breast Cancer Cells

Interplay between estrogen and retinoid signaling in breast cancer – Current and future perspectives

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