Estradiol cypionate aided treatment for experimentally induced ascending placentitis in mares

Curcio, B.R.; Canisso, Igor F.; Pazinato, Fernanda Maria; Borba, Luciana A.; Feijó, Lorena Soares; Müller, Vitória; Finger, Ilusca Sampaio; Toribio, Ramiro E.; Nogueira, Carlos Eduardo Wayne

doi:10.1016/j.theriogenology.2017.03.010

Cited by 16 publications

(19 citation statements)

References 32 publications

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“…As previously shown in authors’ parallel study, neonates delivered from estradiol-treated mares benefited from ECP therapy as characterised by normal foal birth weight, no deaths in the first seven days postpartum and no foals classified as high-risk 27. The findings in the present study suggest that therapeutic estrogen supplementation may aid recovery from ascending placentitis, as evidenced by no septic foals occurring in the TMS+FM+ECP group.…”

Section: Discussionsupporting

confidence: 85%

Peripheral blood markers of sepsis in foals born from mares with experimentally induced ascending placentitis

et al. 2020

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BackgroundNeonatal sepsis is a leading cause of neonatal death during the first-week postfoaling. Despite recent advancements in the diagnosis and treatment of sepsis in the newborn foal, the non-specific clinical signs and subtle nature of this disease may result in delayed diagnosis until severe progression of the disease; thus, early detection of sepsis remains critical for a favourable outcome. This study aimed to identify early blood markers as predictive of sepsis on foals.MethodsThirty-five foals were allocated into three groups: healthy control foals (n=7) and foals born from mares with placentitis: septic foals (n=9) and non-septic foals (n=19). Blood samples were obtained immediately after foaling and at 12, 24 and 48 hours. All samples were assessed for glucose, lactate, triglycerides, total cholesterol, urea, creatinine, total solids, fibrinogen, gamma-glutamyl transferase (GGT), serum amyloid A (SAA) and alpha-fetoprotein (AFP) concentrations.ResultsAt foaling, glucose and GGT concentrations were lower in septic foals (P<0.001). Of interest, SAA, AFP, creatinine and total cholesterol were higher in septic foals at parturition (P<0.05). At 12 hours, lactate, triglycerides and total cholesterol concentrations were higher in septic foals. When evaluated at 24 and 48 hours, higher concentrations of SAA and AFP were found in placentitis foals than in the control group.ConclusionsTotal cholesterol and lactate appear to be suitable markers for sepsis during the first 24 hours postpartum. Septic foals displayed altered energy metabolisms as determined by increased triglycerides and cholesterol concentrations, hypoglycaemia at birth and reduced activity of the GGT and increased lactate and urea concentrations. Sepsis was associated with high concentrations of SAA and AFP.

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Section: Discussionsupporting

confidence: 85%

Peripheral blood markers of sepsis in foals born from mares with experimentally induced ascending placentitis

et al. 2020

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“…Twenty‐nine foals were enrolled in our study from the time of birth to 7 days postpartum. These foals were also included in a parallel study, in which 46 foals were enrolled 18 . However, only foals which serum samples were available were included in the present study.…”

Section: Methodsmentioning

confidence: 99%

“…Five dams carried healthy gestations to term, while 24 dams were submitted to experimental induction of ascending placentitis through intracervical inoculation of 10 7 colony‐forming units of Streptococcus equi subsp. zooepidemicus at 300 days of gestation, as previously described 18 . Mares were assessed daily for the presence of vulvar discharge, early udder development and measurement of the combined thickness of uterus and placenta (CTUP), as described elsewhere 19 .…”

Section: Methodsmentioning

confidence: 99%

Serum cortisol and thyroid hormone concentrations and survival in foals born from mares with experimentally induced ascending placentitis

Müller

Toribio

Dembek

et al. 2020

Veterinary Internal Medicne

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Background: There are few publications on occurrence of nonthyroidal illness syndrome in foals and on the prognostic value of cortisol and thyroid hormone (TH) concentrations in newborn foals.Objectives: To determine serum cortisol and TH concentrations (total and free thyroxine: T 4 and F T 4 ; total and free triiodothyronine: T 3 and F T 3 ) in foals born from mares with placentitis, to determine their association with survival, and their use as prognostic markers.Animals: A cohort of 29 newborn foals comprising 5 Control, 14 Low-risk, and 10 Sick foals were evaluated over the first week of life.Methods: In this prospective study foals born to mares with experimentally-induced placentitis were assigned to Low-risk or Sick groups while foals born to control mares were classified as Control based on clinical findings. Foals were also classified as Term (n = 13), Dysmature (n = 7), or Premature (n = 9), and survival rate was recorded. Serum cortisol and TH hormone concentrations were measured at 0, 12, 24, 48, and 168 hours of life.Results: Sick non-surviving foals had lower (P < .05) T 3 : cortisol ratio at 12 (3.68 ± 1.06 versus 18.58 ± 2.78), 24 (5.47 ± 2.34 versus 23.40 ± 3.82), and 48 (10.47 ± 6.29 versus 26.6 ± 2.90) hours of life when compared to Sick surviving foals and lower (P < .05) T 4 : cortisol ratio at 12 (75.12 ± 21.71 versus 414.47 ± 58.47) and 24 hours (127.83 ± 55.21 versus 430.87 ± 80.31) after birth than Sick surviving foals. Conclusion and Clinical Importance: Placental infections can impair fetal thyroid function. Low T 3 : cortisol and T 4 : cortisol ratios seem to be good prognostic markers in newborn foals. K E Y W O R D S critical ill foals, rognostic marker, thyroxine, triiodothyronine

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“…Otra medida que puede ser tenida en cuenta en eventos futuros como indicador de bienestar fetal es la de estrógeno total plasmático la cual debe ser medida entre los 150 y 280 días de gestación cuyos resultados son >1000 ng/mL para un feto en normalidad, <1000 ng/mL indicador de estrés fetal y <500 ng/mL es indicador de alteraciones gestacionales graves (LeBlanc et al, 2004;Curcio et al, 2017).…”

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“…Es probable que la descarga vulvar esté presente en las yeguas afectadas, pero puede ser producida en cantidades escasas que podría ser difícil de ver sin un examen clínico cuidadoso, además, pequeñas cantidades de descarga vulvar pueden ser fácilmente retiradas de la vulva por los movimientos periódicos de la cola. No obstante, en yeguas con riesgo de placentitis bacteriana se debe hacer seguimiento exhaustivo de la vulva, pelos de la cola y miembros posteriores en busca de pruebas de la descarga procedente del tracto reproductivo caudal; a este respecto, la identificación temprana de los signos clínicos de placentitis facilita el pronto inicio del tratamiento, con el fin de llevar a cabo la gestación a término (Macpherson yBailey 2008;Curcio et al, 2017).…”

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Placentitis bacteriana como causa de aborto en yeguas: reporte de caso

et al. 2018

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La placentitis en yeguas ocasionada por bacterias es una de las causas más importantes de abortos, en Colombia no existe evidencia escrita de su presentación. En el presente artículo se reporta el caso de una yegua Silla Francesa de 10 años de edad, que abortó a los 9 meses de gestación y fue atendida en la Clínica Veterinaria San Jorge - Escuela de Equitación Ejército Nacional en Bogotá. La paciente presentó signos de lactancia prematura y se observó engrosamiento de la placenta, además en los hallazgos histopatológicos predominan cambios vasculares (congestión, edema y fibrina) lo que indica una placentitis aguda. En la tinción de Gram de la placenta se encontraron cocobacilos gram negativos adheridos a la superficie de las células de las vellosidades corioalantóicas y entremezclados con el material proteináceo, aparentemente algunos se ubican intracelularmente; asociando estos fenómenos a un proceso infeccioso por posibles enterobacterias (E.coli o Salmonella spp).

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Estradiol cypionate aided treatment for experimentally induced ascending placentitis in mares

Cited by 16 publications

References 32 publications

Peripheral blood markers of sepsis in foals born from mares with experimentally induced ascending placentitis

Peripheral blood markers of sepsis in foals born from mares with experimentally induced ascending placentitis

Serum cortisol and thyroid hormone concentrations and survival in foals born from mares with experimentally induced ascending placentitis

Placentitis bacteriana como causa de aborto en yeguas: reporte de caso

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