Estradiol decreases the orexigenic effect of melanin-concentrating hormone in ovariectomized rats

Messina, M; Boersma, Gretha J.; Overton, J. M.; Eckel, Lisa A.

doi:10.1016/j.physbeh.2006.05.002

Cited by 66 publications

(56 citation statements)

References 37 publications

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“…3). These findings extend an earlier study [18] by providing the first demonstration that EB treatment induces a right-ward shift in the dose-response curve of the orexigenic effect of MCH. That is, a higher dose of MCH is necessary to induce feeding in EB-treated OVX rats, relative to oil-treated OVX rats.…”

Section: Discussionsupporting

confidence: 87%

“…This action of MCH may be sexually dimorphic, since a similar dipsogenic effect was not observed in MCH-treated female rats [18]. To investigate this hypothesis, water and food intake were monitored in male and female rats in the present study.…”

Section: Discussionmentioning

confidence: 83%

“…In this study, the hyperphagia induced by acute i.c.v. administration of MCH was decreased by estradiol treatment in ovariectomized (OVX) rats [18]. Unlike that observed in male rats [4,10], MCH failed to stimulate water intake, independent of food intake, in either oil-or estradiol-treated OVX rats [18].…”

Section: Introductionmentioning

confidence: 88%

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The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

Santollo

Eckel

2008

Physiology & Behavior

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Recently, it was shown that that the orexigenic effect of melanin concentrating hormone (MCH) is attenuated by estradiol treatment in ovariectomized (OVX) rats. This suggests that female rats may be less responsive than male rats to the behavioral effects of MCH. To investigate this hypothesis, the effects of lateral ventricular infusions of MCH on food intake, water intake, meal patterns, and running wheel activity were examined in male and female rats. To further characterize the impact of estradiol on MCH-induced food intake, female rats were OVX and tested with and without 17-β-estradiol benzoate (EB) replacement. In support of our hypothesis, food and water intakes following MCH treatment were greater in male rats, relative to female rats. Specifically, the orexigenic effect of MCH was maximal in male rats and minimal in EB-treated OVX rats. In both sexes, the orexigenic effect of MCH was mediated by a selective increase in meal size, which was attenuated in EB-treated OVX rats. MCH induced a short-term (2 h) decrease in wheel running that, unlike its effects on ingestive behavior, was similar in males and females. Thus, estradiol decreases some, but not all, of the behavioral effects of MCH. To examine the influence of endogenous estradiol, food intake was monitored following MCH treatment in ovarian-intact, cycling rats. As predicted by our findings in OVX rats, the orexigenic effect of MCH was attenuated in estrous rats, relative to diestrous rats. We conclude that the female rat's reduced sensitivity to the orexigenic effect of MCH may contribute to sex-and estrous cycle-related differences in food intake.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 83%

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The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

Santollo

Eckel

2008

Physiology & Behavior

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“…In animal models, it is known that estradiol has an inhibitory effect on food intake via anorexigenic peptides that decrease meal size. In ovariectomized rats, the removal of estrogens leads to changes in meal size, obesity (33,34), increased leptin sensitivity, and decreased insulin sensitivity (35). However, insulin resistance could also decrease granulosa cell function, which could lead to reduced ovarian function and therefore lower AMH levels (17,18).…”

Section: Discussionmentioning

confidence: 99%

Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer

Dorp

Blijdorp

Laven³

et al. 2013

European Journal of Endocrinology

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Objective: Obesity and gonadal dysfunction are known major side effects of treatment in adult childhood cancer survivors (CCS). In the general population, obesity has a negative influence on female fertility. We aimed to evaluate whether obesity and serum insulin are associated with decreased ovarian reserve markers in CCS. Design: Retrospective single-center cohort study. Methods: Data of 191 female survivors of childhood cancer were analyzed. Median follow-up time was 18.8 (2.3-48.8) years. Outcome measures were serum anti-Mü llerian hormone (AMH) and total follicle count (FC). Potential risk factors were: BMI; body composition measures, determined by dualenergy X-ray absorptiometry (total fat percentage, lean body mass, and visceral fat percentage); and fasting insulin. Results: Lower serum AMH was found in obese subjects (b (%) K49, PZ0.007) and in subjects with fasting insulin in the highest tertile (b (%) K43, PZ0.039). Total fat percentage tends to be associated with serum AMH (b (%) K2.1, PZ0.06). Survivors in the highest tertile of insulin had significantly lower FC than survivors in the lowest tertile (b K6.3, PZ0.013). BMI and other measures of body composition were not associated with FC. Correlation between serum AMH and antral follicle count (AFC) was rZ0.32 (PZ0.08). Conclusions: Obesity and insulin resistance are associated with gonadal damage, as reflected by decreased AMH and reduced FC in adult survivors of childhood cancer. In contrast to its highly predictive value for AFC in the healthy female population, serum AMH does not seem to correlate as well with AFC in CCS.European Journal of Endocrinology 168 905-912

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“…Ludwig et al 2001, Segal-Lieberman et al 2003, Mashiko et al 2005, Bjursell et al 2006) and female models in reproductive studies (e.g. Murray et al 2000b, Garcia et al 2003, Williamson-Hughes et al 2005, Messina et al 2006) may be problematic for intergender extrapolation of results. In metabolic studies, some sexual dimorphism has been reported.…”

Section: Part 3: Mch Energy Balance and Fertilitymentioning

confidence: 99%

The roles of melanin-concentrating hormone in energy balance and reproductive function: are they connected?

Naufahu¹,

Cunliffe²,

Murray³

2013

Reproduction

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Melanin-concentrating hormone (MCH) is an anabolic neuropeptide with multiple and diverse physiological functions including a key role in energy homoeostasis. Rodent studies have shown that the ablation of functional MCH results in a lean phenotype, increased energy expenditure and resistance to diet-induced obesity. These findings have generated interest among pharmaceutical companies vigilant for potential anti-obesity agents. Nutritional status affects reproductive physiology and behaviours, thereby optimising reproductive success and the ability to meet energetic demands. This complex control system entails the integration of direct or indirect peripheral stimuli with central effector systems and involves numerous mediators. A role for MCH in the reproductive axis has emerged, giving rise to the premise that MCH may serve as an integratory mediator between those discrete systems that regulate energy balance and reproductive function. Hence, this review focuses on published evidence concerning i) the role of MCH in energy homoeostasis and ii) the regulatory role of MCH in the reproductive axis. The question as to whether the MCH system mediates the integration of energy homoeostasis with the neuroendocrine reproductive axis and, if so, by what means has received limited coverage in the literature; evidence to date and current theories are summarised herein.Reproduction (2013) 146 R141-R150

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Estradiol decreases the orexigenic effect of melanin-concentrating hormone in ovariectomized rats

Cited by 66 publications

References 37 publications

The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

Decreased ovarian function is associated with obesity in very long-term female survivors of childhood cancer

The roles of melanin-concentrating hormone in energy balance and reproductive function: are they connected?

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