Estradiol in saliva for monitoring follicular stimulation in an in vitro fertilization program

Belkien, L.; Bordt, J.; Möller, Petra; Hano, R.; Nieschlag, Eberhard

doi:10.1016/s0015-0282(16)48855-2

Cited by 23 publications

(20 citation statements)

References 17 publications

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“…Earlier studies have shown that suppressed follicular development may lead to defective luteal function (Riad et al, 1980). Our observation on correlation between relative body weight and mid-follicular oestradiol concentration supports the hypothesis of Belkien et al (1985), that fertility is improved by 5-10% increases in body weight among women who practice weight control. However, Hoff (1983) have demonstration that periods of female weight loss were correlated with decreased ovulatory frequency.…”

Section: Discussionsupporting

confidence: 85%

Residential Exposure of Environment Toxic Substance Outcome during Menstrual Cycle

Alagendran¹

2010

American Journal of Environmental Sciences

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Problem statement: It was intended to diagnose and treat the disorders of female reproductive system where they are exposed to environmentally toxic pesticides and estrogenic compounds like bisphenol A which are the main reason for the infertility problems. Approach: Human saliva contains arrays of proteins that have distinct biological functions. Results: Salivary hormones concentrations of luteinising hormone, follicle stimulating hormone, estrogen as well as estrone-1-glucuronide, were assayed in 20 normal menstruating women who were among the reproductive phases like preovulatory phase (6-12 days); Ovulatory phase (13-14 days) and Postovulatory phase (15-26 days). It was intended to diagnose and treat the disorders of female reproductive system where they are exposed to environmentally toxic pesticides and estrogenic compounds like bisphenol A which are the main reason for the infertility problems. In this context, the detection of fertile period suggests that the mean value of luteinising hormone (56.58±12.96 mIU L −1 ) indicates the surge during the time of ovulation.Identifying the period of ovulation would be the easiest way to detect other constituents like follicle stimulating hormone, estrogen and its conjugate like estrone-1-glucuronide are extensively high (p<0.05) was observed. Conclusion: Our results indicated that the salivary hormones like estrogen and its conjugate indicates decrease in ovulatory and postovulatory phase. Further, the environmental toxic materials can also cause problems like infertility. The conclusion is that any physiological effects of estrogen from drinking water will be undetectable in people. The results from hormones suggested that they may be considered in the diagnosis and treatment of ovulation using saliva as the noninvasive specimen.

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Section: Discussionsupporting

confidence: 85%

Residential Exposure of Environment Toxic Substance Outcome during Menstrual Cycle

Alagendran¹

2010

American Journal of Environmental Sciences

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“…Overexpression of EGF-type GFs is strongly associ-0.78 (P = 0.003) for EGF and r = 0.89 (P = 0.0001) for ated with mammary cancer in transgenic mice and the early TGF-a. For both GFs, the variation between women was stages of spontaneous mammary tumor development in normal substantially greater than the variation between breasts mice (6,7). It is plausible, therefore, to hypothesize that healthy or over time in an individual woman, particularly for women with excessive production of these mitogenic GFs have EGF, for which there were 100-fold differences between an elevated risk of developing breast cancer.…”

mentioning

confidence: 87%

“…For EGF, the within-woman variation (between breasts) was considerably less than the variation in EGF levels 60 between women. The ICC implies that 48% of the total vari-"a 6 ance in EGF could be attributed to between-woman differences.…”

Section: Gf Concentrationsmentioning

confidence: 99%

“…A substantial body of eviOur results, which are among the first data availdence, including findings with the TGF-ot transgenic able on growth factor concentrations in prostatic fluid, mouse, indicates that upregulation of EGF-related suggest that there are important associations between peptides is involved in the development of preneothese concentrations and the presence of neoplastic or plastic conditions in several types of tissue [6,7]. The hyperplastic disease in the prostate.…”

Section: Sample Collection and Storagementioning

confidence: 99%

“…TGF-cx lower bound of the 95% confidence interval for each was not detectable in any sample from 2 men. Three ICC using the method described by Fleiss [6]. We also other men had one sample that was considered noncalculated CVs within and between men and F statisdetectable, yielding a total of 20 TGF-a pairs for analytics from a one-way analysis of variance (ANOVA) sis.…”

Section: Introductionmentioning

confidence: 99%

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Developing New Epidemiologic Tools for Investigating Breast Cancer Risk

Gann¹

1999

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The impact of developmental conditions on adult salivary estradiol levels: Why this differs from progesterone?

Mora

Bentley

Choudhury

et al. 2007

American J Hum Biol

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Women living in energetically stressful conditions have significantly lower baseline salivary steroid levels compared to those in affluent environments. Developmental hypotheses suggest that interpopulation variation in ovarian function results from contrasting environments experienced during growth. We use a migrant study of Bangladeshi women to test this hypothesis. We compared middle-class women (19-39 years) who migrated to London, UK, at different life-stages (pre and postmenarche), with Bangladeshi sedentees, second-generation British-Bangladeshis, and white British women living in similar London neighborhoods (total n = 227). We analyzed levels of salivary estradiol for one menstrual cycle, together with data on anthropometry, diet, lifestyle, and migration and reproductive histories. Results from multiple linear regression models, controlling for anthropometric and reproductive variables, show no significant differences in baseline estradiol levels between groups whether all cycles or just ovulatory cycles are analyzed. We also found no correlation between age at migration or time since migration on estradiol levels, nor between adult estradiol levels and age at menarche. Our results differ from previous reports of significantly lower salivary estradiol levels in populations living in more extreme ecological settings. They also contrast with our previous findings of significant intergroup differences in baseline levels of salivary progesterone. However, women who spent their childhood in Sylhet have a lower proportion of ovulatory cycles compared to women who developed in Britain. These group differences in ovulation frequency indicate more qualitative effects of contrasting developmental environments. We discuss possible explanations for differences in response between progesterone and estradiol, as well as broader implications of our findings.

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Estradiol in saliva for monitoring follicular stimulation in an in vitro fertilization program

Cited by 23 publications

References 17 publications

Residential Exposure of Environment Toxic Substance Outcome during Menstrual Cycle

Residential Exposure of Environment Toxic Substance Outcome during Menstrual Cycle

Developing New Epidemiologic Tools for Investigating Breast Cancer Risk

The impact of developmental conditions on adult salivary estradiol levels: Why this differs from progesterone?

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