Estradiol-independent growth of a subline of MCF-7 human breast cancer cells in culture.

Nawata, Hajime; Chong, Ming Ta; Bronzert, Diane A.; Lippman, Marc E.

doi:10.1016/s0021-9258(19)69076-9

Cited by 64 publications

(2 citation statements)

References 32 publications

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“…Hormonal synchronization was included in the chemotherapy regimens in all but 5 patients in this series. The rationale for this approach has its foundation in prior studies from our laboratory [24][25][26] which demonstrated that antiestrogen-induced inhibition of breast cancer cell growth could be reversed by estrogen rescue. Weichselbaum et al [27] showed that this technique could increase the sensitivity of breast cancer cells to cytotoxic drug exposure.…”

Section: Discussionmentioning

confidence: 99%

The management of nonmetastatic locally advanced breast cancer using primary induction chemotherapy with hormonal synchronization followed by radiation therapy with or without debulking surgery

et al. 1985

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Forty‐three patients with locally advanced breast cancer, 15 with stage IIIA and 28 with stage IIIB, received primary induction chemotherapy, including hormonal synchronization in 38 patients, to a maximum objective clinical response before proceeding to local therapy. Patients achieving a pathological complete response received radiation therapy, while patients with residual disease, partial response (PR), or no change (NC) status received debulking surgery prior to radiation therapy; in all patients, 6 additional months of chemotherapy were administered. Chemotherapy consisted of cyclophosphamide 500 mg/m2 and doxorubicin 30 mg/m2 intravenously day 1; tamoxifen 40 mg/m2 orally days 2–6; premarin 0.625 mg orally every 12 hours 3 times beginning on day 7; methotrexate (mtx) 300 mg/m2 intravenously followed in 1 hour by 5‐fluorouracil 500 mg/m2 intravenously day 8, and leucovorin 10 mg/m2 orally every 6 hours 6 times beginning 24 hours after mtx. Forty‐two patients are evaluable with respect to response, time to progression, and survival. Objective response rate to chemotherapy was 90% with 50% CR, 40% PR, and 10% NC. Median number of cycles of chemotherapy to achieve a CR, PR, or NC was 5, 4, and 4 respectively. Eighteen patients with a CR to chemotherapy were assessed by multiple biopsies (16 patients) or mastectomy (2 patients). Fourteen patients (70%) were proven to be pathological complete responders. Thirty patients have completed combined therapy thus far and all have been rendered disease free. Seven stage IIIB patients have relapsed, 6 of them having inflammatory histological findings. No stage IIIA patients have relapsed. Median survival and time to progression have not been reached for either stage.

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Section: Discussionmentioning

confidence: 99%

The management of nonmetastatic locally advanced breast cancer using primary induction chemotherapy with hormonal synchronization followed by radiation therapy with or without debulking surgery

et al. 1985

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“…Nevertheless, due to the limited data availability, we must additionally depend on prior estimations of certain rates and values derived from other scholarly modeling publications. The estimation of the growth rate α 1 is derived from the data [36], while the determination of the carrying capacity is based on the findings from the research [37][38][39]. Estimating the values of parameters α 1 and α 4 is based on the analysis of experimental data [40].…”

Section: Mathematical Modelmentioning

confidence: 99%

Mathematical Modeling of Breast Cancer Based on the Caputo–Fabrizio Fractal-Fractional Derivative

Idrees,

Alnahdi,

Jeelani

2023

Fractal Fract

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Breast cancer ranks among the most prevalent malignancies affecting the female population and is a prominent contributor to cancer-related mortality. Mathematical modeling is a significant tool that can be employed to comprehend the dynamics of breast cancer progression and dissemination and to formulate novel therapeutic approaches. This paper introduces a mathematical model of breast cancer that utilizes the Caputo–Fabrizio fractal-fractional derivative. The aim is to elucidate and comprehend the intricate dynamics governing breast cancer cells and cytotoxic T lymphocytes in the context of the fractional derivative. The derivative presented herein offers a broader perspective than the conventional derivative, as it incorporates the intricate fractal characteristics inherent in the process of tumor proliferation. The significance of this study lies in its contribution to a novel mathematical model for breast cancer, which incorporates the fractal characteristics of tumor development. The present model possesses the capability to investigate the impacts of diverse treatment strategies on the proliferation of breast cancer, as well as to formulate novel treatment strategies that exhibit enhanced efficacy.

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Hormone and cytotoxic drug responsiveness of cultured human breast cancer cells resistant to specific hormones

Coldham¹,

Patel²,

Braunsberg³

1990

Intl Journal of Cancer

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Attempts have been made to develop sublines of MCF-7 cells resistant to the growth-inhibitory actions of medroxyprogesterone acetate (MPA), dexamethasone (DEX), anti-oestrogens or high-dose oestradiol (E2) by prolonged exposure to high hormone concentrations. While high degrees of resistance to MPA, DEX and E2 were achieved, cells remained anti-oestrogen-sensitive after prolonged treatment with 4 microM tamoxifen (TAM) or the anti-oestrogen LY 117018 (LY). Cells resistant to DEX were also resistant to MPA, while cells resistant to high-dose E2 remained sensitive to TAM. Cells resistant to MPA and E2 appeared to be less responsive to cytotoxic drugs than wild-type cells, while resistance to DEX was associated with increased sensitivity. The responses of tumours to cytotoxic drugs may be affected by prior endocrine therapy.

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Estradiol-independent growth of a subline of MCF-7 human breast cancer cells in culture.

Cited by 64 publications

References 32 publications

The management of nonmetastatic locally advanced breast cancer using primary induction chemotherapy with hormonal synchronization followed by radiation therapy with or without debulking surgery

The management of nonmetastatic locally advanced breast cancer using primary induction chemotherapy with hormonal synchronization followed by radiation therapy with or without debulking surgery

Mathematical Modeling of Breast Cancer Based on the Caputo–Fabrizio Fractal-Fractional Derivative

Hormone and cytotoxic drug responsiveness of cultured human breast cancer cells resistant to specific hormones

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