Estradiol-induced progesterone receptor synthesis in normal and diabetic ovariectomized rat uterus

Ekka, E.; Vanderheyden, I.; Glorieux, B.; Hertogh, R. De

doi:10.1016/0022-4731(87)90125-7

Cited by 9 publications

(9 citation statements)

References 21 publications

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“…Earlier work has shown that oestrogen receptor kinetics were essentially normal in non-pregnant diabetic rats [16,17]. Also, oestrogens were able to stimulate progestogen receptor synthesis in diabetic as well as in non-diabetic ovariectomized rats [30]. A similar conclusion can be drawn from the present study in diabetic pregnant animals.…”

Section: Discussionsupporting

confidence: 90%

“…Decreased oestrogen [31][32][33] and corticosterone [34] receptor levels have been reported in the central nervous system, and decreased androgen receptor levels [35] in the prostate of diabetic rats. However, in uterine tissues of non-pregnant rats, normal oestrogen and progesterone receptor levels were found, from a few days up to several months after onset of diabetes, despite loss of weight and progressive catabolic state [16,17,30]. The cause of the decreased oestrogen receptor levels in implantation sites of diabetic rats is not known.…”

Section: Discussionmentioning

confidence: 97%

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Oestrogen and progestogen receptors in endometrium and myometrium at the time of blastocyst implantation in pregnant diabetic rats

Hertogh¹,

Vanderheyden²,

Glorieux³

et al. 1989

Diabetologia

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Summary.A suitable hormonal environment is a prerequisite for blastocyst implantation. Experimental diabetes was previously shown to modify the hormonal milieu and produce alterations in oestrogen receptor kinetics in the uterine tissue. In the present work, oestrogen and progestogen receptor levels were measured on the morning of day 6 of pregnancy in normal and in streptozotocin-induced diabetic rats, both in implantation sites and in interembryonic segments of endometrium and myometrium. Receptor levels were different in the implantation sites compared to the interembryonic segments of endometrium, both in the control and in the diabetic animals. Indeed, implantation sites were characterized by lower oestrogen receptor levels in cytosol and higher progestogen receptor levels in cytosol and nuclei. However, compared to the control rats, the diabetic rats had lower oestrogen receptor levels in implantation sites, both in cytosol and nuclei. In the myometrium, the differences between sites or between types of rats were minimal. Plasma levels of oestradiol were lower in diabetic rats than in control animals, whereas progesterone levels were similar. A 20% lower implantation rate was found in diabetic rats, compared to normal rats. These results show that the specific distribution of oestrogen and progestogen receptors between implantation sites and interembryonic segments was preserved in the diabetic rats; however the absolute level of oestrogen receptor was lower. This abnormal endocrine milieu might arise from a lower oestradiol level and a decreased oestradiol/progesterone ratio in the circulating blood. Whether the lower implantation rate in diabetic rats might be a consequence of the overall disturbed hormonal status remains to be elucidated.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Oestrogen and progestogen receptors in endometrium and myometrium at the time of blastocyst implantation in pregnant diabetic rats

Hertogh¹,

Vanderheyden²,

Glorieux³

et al. 1989

Diabetologia

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“…Ekka et al showed similar estrogen-induced progesterone receptor expression in uterine tissues in a type 1 diabetic rat animal model [20], and reductions in AR expression have been previously demonstrated in a type 1 diabetic animal model [15]. Interestingly, in our study, estrogen supplementation down-regulated ER␣ expression in diabetic animals beyond levels detected in untreated diabetic animals.…”

Section: Discussionsupporting

confidence: 76%

Estradiol restores diabetes-induced reductions in sex steroid receptor expression and distribution in the vagina of db/db mouse model

Cushman

Kim

Hoyt

et al. 2009

The Journal of Steroid Biochemistry and Molecular Biology

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“…However, at the end of proestrus, serum levels of progesterone are increased in the rat [33]. It is noteworthy that in the rat uterus, the number of progesterone receptors is under the control of both estrogen and progesterone; estrogen increases progesterone receptor concentration while progesterone decreases receptor concentration [34][35][36].…”

Section: Discussionmentioning

confidence: 99%

CaBP9K Levels during the Luteal and Follicular Phases of the Estrous Cycle in the Bovine Uterus1

Inpanbutr

Miller

Petroff

et al. 1994

Biology of Reproduction

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The expression of calbindin-D9K (CaBP9K) and calbindin-D28K (CaBP28K) genes in the reproductive system is well established for rodent and avian species, but not for domestic livestock. This investigation expanded the study of these proteins to include the bovine uterus and examined the levels of CaBP9K and CaBP9K mRNA in the nonpregnant bovine uterus during the estrous cycle. Immunohistochemical studies revealed that CaBP9K was present in all uterine glandular and luminal epithelial cells. In contrast, the closely related calcium binding protein CaBP28K was present in only one to two glandular cells in the samples examined. Neither protein was localized in the myometrium or in the stromal cells of the endometrium. RIA and dot blot hybridization were used to quantify the amount of CaBP9K and CaBP9K mRNA. The levels of both the protein and its mRNA were threefold higher during the luteal phase than during the follicular phase. RIA was also used to determine bovine uterine levels of 17 beta-estradiol and progesterone. Progesterone levels were higher during the luteal phase than during the follicular phase, while 17 beta-estradiol levels were higher during the follicular phase. This investigation represents the first characterization of CaBP9K gene expression in the bovine uterus. It demonstrated that the expression of CaBP9K and CaBP9K mRNA was greatest during the progesterone-dominated luteal phase of the bovine estrous cycle. These results indicated that CaBP9K may be involved in uterine glandular function during the luteal phase.

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Estradiol-induced progesterone receptor synthesis in normal and diabetic ovariectomized rat uterus

Cited by 9 publications

References 21 publications

Oestrogen and progestogen receptors in endometrium and myometrium at the time of blastocyst implantation in pregnant diabetic rats

Oestrogen and progestogen receptors in endometrium and myometrium at the time of blastocyst implantation in pregnant diabetic rats

Estradiol restores diabetes-induced reductions in sex steroid receptor expression and distribution in the vagina of db/db mouse model

CaBP9K Levels during the Luteal and Follicular Phases of the Estrous Cycle in the Bovine Uterus1

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