Estradiol induces hypothalamic progesterone receptors but does not activate mating behavior in male hamsters (Mesocricetus auratus) before puberty.

Romeo, Russell D.; Wagner, Christine K.; Jansen, Heiko T.; Diedrich, Stefani L.; Sisk, Cheryl L.

doi:10.1037/0735-7044.116.2.198

Cited by 28 publications

(16 citation statements)

References 37 publications

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“…Previous studies using these time-released pellets have shown prepubertal and adult males treated with the same size pellet experience similar levels of the steroid, e.g., testosterone [15, 16, 17], estradiol [18], or corticosterone [19]. …”

Section: Discussionmentioning

confidence: 99%

Testosterone Cannot Activate an Adult-Like Stress Response in Prepubertal Male Rats

et al. 2004

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The pubertal maturation of the hypothalamic-pituitary-adrenal (HPA) axis has received relatively little experimental attention. The present set of experiments sought to extend our understanding of the pubertal stress response by measuring corticotropin (ACTH), corticosterone, and testosterone levels in prepubertal and adult male rats exposed to a single 30-min session of restraint stress. We show that ACTH and corticosterone levels in prepubertal males take significantly longer to return to baseline after termination of the stressor compared to adults. These data indicate that prepubertal males demonstrate a more prolonged stress response compared to adults after a single acute stressor with both psychogenic and neurogenic components. As testosterone has been shown to reduce the stress response in adulthood, we next investigated whether the relatively low levels of circulating testosterone in prepubertal males mediated their protracted stress response. Data collected from additional experiments revealed that prepubertal males treated with adult-like physiological levels of testosterone still exhibited an extended stress response compared to similarly treated adults. These results indicate that the stress response demonstrated by adult males cannot be mimicked or activated in prepubertal males by mere supplementation of testosterone. Thus, we conclude that the HPA neuroendocrine axis is further shaped during pubertal development to allow for the emergence of a more tightly regulated stress response in adulthood.

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Section: Discussionmentioning

confidence: 99%

Testosterone Cannot Activate an Adult-Like Stress Response in Prepubertal Male Rats

et al. 2004

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“…The sexually naive subjects received a standardized behavior test between 1700 and 2030 h EST (Meek et al, 1997;Romeo et al, , 2002Schulz et al, 2004). Following a 5 min acclimation to the test chamber, male subjects interacted with a stimulus female for 15 min.…”

Section: Sexual Behaviormentioning

confidence: 99%

Dendritic pruning of the medial amygdala during pubertal development of the male Syrian hamster

et al. 2006

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The medial amygdala (Me), a brain region essential for mating behavior, changes in size during puberty. In pre-, mid-, and late pubertal (21, 35, and 49 days of age) male Syrian hamsters, we examined neuronal structure in Me and protein levels of spinophilin and synaptophysin in the amygdaloid complex for evidence of synaptic plasticity coincident with behavioral and physiological development. Body weight, testes weight, and testosterone levels increased during puberty. Mounting behavior, including ectopic, nonintromittive, and intromittive mounts, also increased. Neuronal structure in the posterodorsal medial amygdala (MePD) was assessed in Golgi-impregnated neurons. Pruning occurred during puberty in the number of dendrites emanating from the cell body and in terminal dendritic spine densities. Approximately half of all MePD neurons analyzed had an axon emanating from a dendrite rather than the cell body. However, prepubertal males were more likely to have the axon emanating from a higher order dendritic segment (secondary or tertiary) than were mid- and late pubertal males. Finally, protein levels in the amygdaloid complex varied with pubertal age. Spinophilin decreased, while synaptophysin and GAPDH protein levels increased. These results suggest that puberty is a period of dramatic synaptic plasticity in Me. Specifically, pruning of dendrites and spines, in combination with axonal changes, is likely to modify the afferent influences and electrophysiological properties of Me neurons. Because the Me is an integral component of a social behavior neural network, these changes may be related not only to sexual behavior, but also to other behaviors that mature during puberty, including aggressive, risk-taking, fear-related, and parental behaviors.

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“…In reviewing the literature, we found studies that examined the effects of estradiol on progesterone receptors experimentally. This literature indicates that estradiol up-regulates estrogen and progesterone receptors [13] and can induce expression of hypothalamic progesterone receptors [19]. As a result, we believe that the indirect effect of estrogen on progesterone receptors (i.e., up-regulation of progesterone receptors in the tumor and hypothalamus) changed the natural history of the meningioma and enhanced tumor growth in our patient.…”

Section: Tumor Growth In First Examinationmentioning

confidence: 72%

“…Estradiol up-regulates progesterone receptors through α-estradiol receptors and can also stimulate hypothalamic progesterone receptors in the Medial Pre optic Nucleus (MPN) [13]. Some studies show that estradiol plays an important role in the ontogenic expression of progesterone receptors during postnatal uterine maturation in rats [14].…”

Section: Meningioma: the Unusual Growth In A Transsexual Patient Aftementioning

confidence: 99%

Meningioma: The Unusual Growth in a Transsexual Patient after Estrogen-Progesterone Therapy

Borghei-Razavi¹,

Fragoza-Padilla²,

Hargus³

et al. 2014

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Estradiol induces hypothalamic progesterone receptors but does not activate mating behavior in male hamsters (Mesocricetus auratus) before puberty.

Cited by 28 publications

References 37 publications

Testosterone Cannot Activate an Adult-Like Stress Response in Prepubertal Male Rats

Testosterone Cannot Activate an Adult-Like Stress Response in Prepubertal Male Rats

Dendritic pruning of the medial amygdala during pubertal development of the male Syrian hamster

Meningioma: The Unusual Growth in a Transsexual Patient after Estrogen-Progesterone Therapy

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