Estradiol Mediates Effects of Testosterone on Vasotocin Immunoreactivity in the Adult Quail Brain

Viglietti‐Panzica, C.; Balthazart, Jacques; Plumari, L.; Fratesi, Stefania; Absil, Philippe; Panzica, G. C.

doi:10.1006/hbeh.2001.1710

Cited by 45 publications

(32 citation statements)

References 42 publications

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“…In parallel, the restoration by T of the VT immunoreactivity in the POM, BSTm, and lateral septum of castrated male quail can be fully mimicked by a treatment with E 2 . The androgen DHT had absolutely no effect on the VT immunoreactivity in these conditions, and at the doses used, DHT did not synergize with E 2 to enhance the density of VT-ir structures (42). The steroid sensitivity of the VT-ir structures in the male quail brain thus brings additional support to the idea that this neuropeptide is more or less directly involved in the control of male sexual behavior.…”

Section: Effects Of Gonadal Steroids In Adult Birdsmentioning

confidence: 81%

“…Castration also completely eliminates neurons expressing VT mRNA in the sexually dimorphic parvocellular VT cell groups, located in the POM and in the anterior and posterior part of the BSTm. These effects are completely reversed by a 3-week treatment with exogenous T. These changes are observed only at the level of the sexually dimorphic neurons of the limbic and preoptic regions and not at the level of the magnocellular neurons located in the paraventricular and supraoptic nuclei or at the level of the hypothalamo-neurohypophysial tract (17,(39)(40)(41)(42).…”

Section: Effects Of Gonadal Steroids In Adult Birdsmentioning

confidence: 95%

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The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

Panzica

Balthazart

Pessatti³

et al. 2002

Environ Health Perspect

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Vasotocin (VT; the antidiuretic hormone of birds) is synthesized by diencephalic magnocellular neurons projecting to the neurohypophysis. A sexually dimorphic system of VT-immunoreactive (ir) parvocellular elements has been described within the male medial preoptic nucleus (POM) and the nucleus of the stria terminalis, pars medialis (BSTm). VT-ir fibers are present in many diencephalic and extradiencephalic locations, and quantitative morphometric analyses demonstrated their sexually dimorphic distribution in regions involved in the control of different aspects of reproduction. Moreover, systemic or intracerebroventricular injections of VT markedly inhibit the expression of some aspects of male sexual behavior. In adult animals, circulating levels of testosterone (T) have a profound influence on the VT immunoreactivity within BSTm, POM, and lateral septum. Castration markedly decreases the immunoreaction, whereas T-replacement therapy restores a situation similar to the intact birds. We observed no changes in gonadectomized females treated with T. These changes parallel similar changes in male copulatory behavior (not present in castrated male quail, fully expressed in castrated, T-treated males). The restoration by T of the VT immunoreactivity in castrated male quail could be fully mimicked by a treatment with estradiol (E(2)), suggesting that the aromatization of T into E(2) may play a key limiting role in both the activation of male sexual behavior and the induction of VT synthesis. This dimorphism has an organizational nature: administration of E(2) to quail embryos (a treatment that abolishes male sexual behavior) results in a dramatic decrease of the VT immunoreactivity in sexually dimorphic regions. Conversely, the inhibition of E(2) synthesis during embryonic life (a treatment that stimulates the expression of male copulatory behavior in treated females exposed in adulthood to T) results in a malelike distribution of VT immunoreactivity. The VT parvocellular system of the Japanese quail can therefore be considered an accurate marker of the sexual differentiation of brain circuits mediating copulatory behavior and could be a very sensitive indicator of the activity of estrogenlike substances on neural circuits.

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Section: Effects Of Gonadal Steroids In Adult Birdsmentioning

confidence: 81%

Section: Effects Of Gonadal Steroids In Adult Birdsmentioning

confidence: 95%

The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

Panzica

Balthazart

Pessatti³

et al. 2002

Environ Health Perspect

Self Cite

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“…Sections were then stained either for Nissl bodies or for aromatase or vasotocin by immunohistochemistry (for procedures, see Foidart et al, 1995;Absil et al, 2002a, respectively). The vasotocin and aromatase immunoreactivity in the POM, as well as the volume of this nucleus as defined by Nissl staining, have been shown to depend on the synergistic action of androgens and estrogens and to be causally related to the expression of male sexual behavior (Panzica et al, 1987;Aste et al, 1998;Panzica et al, 2001;Viglietti-Panzica et al, 2001). These proteins are therefore excellent markers to study the potential modulation of steroid activity in this brain region.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of Steroid Receptor Coactivator-1 Blocks Estrogen and Androgen Action on Male Sex Behavior and Associated Brain Plasticity

Charlier¹,

Ball²,

Balthazart³

2005

J. Neurosci.

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“…As in mammals (which express a homologous neuropeptide, arginine vasopressin), the AVT neuronal population of the BSTm is often sexually dimorphic and innervates the LS in a male-biased fashion (Viglietti-Panzica et al, 1992, 1994Jurkevich et al, 1999). In most species examined, this system is strongly regulated by testosterone (T) (Voorhuis et al, 1988;Viglietti-Panzica et al, 1992;Aste et al, 1997;Panzica et al, 1999a;Plumari et al, 2004), and data from Japanese quail (Coturnix japonica) show that T regulates AVT primarily via its aromatization to estradiol (E 2 ) (Viglietti- Panzica et al, 2001). Also similar to mammals, AVT acts within the septum to modulate stress responsivity and agonistic behavior (Goodson, 1998a;Goodson and Evans, 2004).…”

Section: Vasotocin Sex Steroids and Aggressionmentioning

confidence: 99%

“…The accompanying rise in circulating T coordinates a variety of processes in the brain, many of which require that T be aromatized to E 2 . These include, but are not limited to, increased expression of neuropeptides (e.g., AVT within the BSTm-LS system) (Viglietti- Panzica et al, 2001;Plumari et al, 2004), dramatic restructuring and growth of telencephalic song nuclei (Tramontin & Brenowitz, 2000;Nottebohm, 2004), and an increase in aromatase activity within the VMH and POA (Vockel et al, 1990).…”

Section: Multi-system Integration: Birdsong and Neuroendocrine Cascadesmentioning

confidence: 99%

Recent advances in behavioral neuroendocrinology: Insights from studies on birds

Goodson

Saldanha

Hahn

et al. 2005

Hormones and Behavior

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Ever since investigations in the field of behavioral endocrinology were hatched with experiments on roosters, birds have provided original insights into issues of fundamental importance for all vertebrate groups. Here we focus on more recent advances that continue this tradition, including 1) environmental regulation of neuroendocrine and behavioral systems, 2) steroidogenic enzyme functions that are related to intracrine processes and de novo production of neurosteroids, and 3) hormonal regulation of neuroplasticity. We also review recent findings on the anatomical and functional organization of steroid-sensitive circuits in the basal forebrain and midbrain. A burgeoning body of data now demonstrates that these circuits comprise an evolutionarily conserved network, thus numerous novel insights obtained from birds can be used (in a relatively straightforward manner) to generate predictions for other taxa as well. We close by using birdsong as an example that links these areas together, thereby highlighting the exceptional opportunities that birds offer for integrative studies of behavioral neuroendocrinology, and behavioral biology in general. Keywords aggression; reproduction; song; limbic system; vasotocin; photoperiod; neurosteroid; DHEA; aromatase; adult neurogenesis; estrogen; testosterone; thyroxin; hypothalamus; hippocampus; HVC; septum; GnRH; SCN; season; neuroplasticity Birds offer excellent opportunities for behavioral and neuroendocrine experiments in both the field and the laboratory, and studies conducted at this interface have historically placed avian models on the cutting edge of research (Konishi et al., 1989; also see Wingfield, this issue). Indeed, wild birds offer a combination of accessibility (being diurnal and terrestrial) and diversity (social and ecological) that makes them invaluable models for studying mechanistic and evolutionary questions that are not as tractable in other vertebrate groups. This diversity can be studied within the context of neural and endocrine systems that share many features with those of other taxa (thereby increasing the general relevance of avian studies) (Goodson, 2005), although these features are often more pronounced in birds. Such examples include exceptionally robust and widespread neural aromatase activity, and adult neurogenesis in the forebrain, both of which are considered further below (also see Ball and Balthazart, 2004;

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Estradiol Mediates Effects of Testosterone on Vasotocin Immunoreactivity in the Adult Quail Brain

Cited by 45 publications

References 42 publications

The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

The parvocellular vasotocin system of Japanese quail: a developmental and adult model for the study of influences of gonadal hormones on sexually differentiated and behaviorally relevant neural circuits.

Inhibition of Steroid Receptor Coactivator-1 Blocks Estrogen and Androgen Action on Male Sex Behavior and Associated Brain Plasticity

Recent advances in behavioral neuroendocrinology: Insights from studies on birds

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