Estradiol production during controlled ovarian hyperstimulation correlates with treatment outcome in women undergoing in vitro fertilization–embryo transfer

Mitwally, M.F.; Bhakoo, Helmata S.; Crickard, Kent; Sullivan, Michael; Batt, Ronald E.; Yeh, John

doi:10.1016/j.fertnstert.2006.02.086

Cited by 75 publications

(45 citation statements)

References 55 publications

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“…Ozcakir et al [9] have evaluated this association after use of clomiphene citrate and HMG followed by intrauterine insemination of 180 patients and reported that there is no correlation between E2 level and clinical pregnancy [9]. Also, Mitwally et al [8] have investigated the association of E2 level during COH and peak E2 pregnancy outcome in 270 patients and reported the positive correlation between estradiol during COH and pregnancy outcome, but not between E2 on hCG administration day and pregnancy outcome. In their study, they used GnRH agonist and gonadotropin [8].…”

Section: Discussionmentioning

confidence: 99%

“…Also, Mitwally et al [8] have investigated the association of E2 level during COH and peak E2 pregnancy outcome in 270 patients and reported the positive correlation between estradiol during COH and pregnancy outcome, but not between E2 on hCG administration day and pregnancy outcome. In their study, they used GnRH agonist and gonadotropin [8]. E2 level in IVF procedure is subject of GnRH agonist and antagonist for down-regulation of ovary controlled by COH.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Serum Estradiol Level on the Day of hCG Administration and IVF–ICSI Outcome

Foroozanfard

Moraveji

Taghavi

et al. 2015

J Obstet Gynecol India

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Background Controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) is essential in improving the pregnancy rate, but supraphysiologic levels of estradiol (E2), which are attained during COH and which affect the outcome of IVF, have remained unclear. The aim of this study was to evaluate the association of E2 levels on the day of hCG with embryo quality and pregnancy rates in long protocol in IVF. Materials and Methods We retrospectively reviewed 128 IVF cycles. All the patients were stimulated with long protocol. The patients were categorized into three groups according to the serum E2 levels on hCG administration day (group 1; \1500 pg/ml, group 2; 1500-3500 pg/ml, group 3; [3500 pg/ml). Results Of the 128 cycles, 23 (18 %) cycles resulted in pregnancy. There were no statistically significant differences between mean age, duration of infertility, BMI and FSH on cycle day 3 in three groups. The number of the retrieved oocytes, the number of obtained embryos, the number of transferred embryos, and pregnancy rates were gradually increased from group 1 to 3 as estradiol levels increased, and these values were statistically significant (P \ 0.05). In addition, the correlation between age and IVF outcome was found. Mean age in patients with positive

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association Between Serum Estradiol Level on the Day of hCG Administration and IVF–ICSI Outcome

Foroozanfard

Moraveji

Taghavi

et al. 2015

J Obstet Gynecol India

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“…Since women with breast cancer typically have a window of approximately 6 weeks between surgery and the initiation of adjuvant chemotherapy, it is feasible to undergo controlled ovarian stimulation (COS) [9][10][11]. The supraphysiologic estrogen (E2) levels resulting from traditional stimulation protocols have precluded most oncologists and breast cancer patients from pursuing fertility preservation, fearing the high estrogenic state can promote cancer growth or recurrence [12,13].…”

Section: Introductionmentioning

confidence: 99%

Triggering final oocyte maturation with gonadotropin-releasing hormone agonist (GnRHa) versus human chorionic gonadotropin (hCG) in breast cancer patients undergoing fertility preservation: an extended experience

Reddy

Turan

Bedoschi

et al. 2014

J Assist Reprod Genet

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Purpose To analyze the cycle outcomes and the incidence of ovarian hyperstimulation syndrome (OHSS), when oocyte maturation was triggered by gonadotropin-releasing hormone agonist (GnRHa) versus human chorionic gonadotropin (hCG) in breast cancer patients undergoing fertility preservation. Methods One hundred twenty-nine women aged≤45 years, diagnosed with stage≤3 breast cancer, with normal ovarian reserve who desired fertility preservation were included in the retrospective cohort study. Ovarian stimulation was achieved utilizing letrozole and gonadotropins. Oocyte maturation was triggered with GnRHa or hCG. Baseline AMH levels, number of oocytes, maturation and fertilization rates, number of embryos, and the incidence of OHSS was recorded. Results The serum AMH levels were similar between GnRHa and hCG groups (2.7±1.9 vs. 2.1±1.8; p=0.327). There was one case of mild or moderate OHSS in the GnRHa group compared to 12 in the hCG group (2.1 % vs. 14.4 %, p=0.032). The maturation and fertilization rates, and the number of cryopreserved embryos were significantly higher in the GnRHa group.Conclusions GnRHa trigger improved cycle outcomes as evidenced by the number of mature oocytes and cryopreserved embryos, while significantly reducing the risk of OHSS in breast cancer patients undergoing fertility preservation.

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“…[6][7][8] Study in 2006 showed that in high responders even though the proportion of immature oocytes were more, pregnancy outcome is not impaired. 9 This is supported by our study.…”

Section: Discussionmentioning

confidence: 99%

Correlation between number of mature eggs retrieved and live birth rate in IVF treatment

Rana¹,

Bavishi²,

Bavishi³

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONThe development of assisted reproductive technologies has revolutionized the treatment of Infertility. The 1 st IVF baby Louise Brown was born in 1978 by the pioneering efforts of Prof Edwards and Steptoe for which Prof Edwards was honoured with the Nobel Prize in medicine in 2010. The first IVF was natural cycle IVF in which one oocyte during natural cycle was retrieved. In natural cycle of a female one mature oocyte is released so that the rate of cancellation of cycle was high and success was less. 1In order to overcome that controlled ovarian hyper stimulation was introduced to facilitate multifollicular development and hence multiple oocyte and availability of more than one embryo for transfer. But this procedure can cause complication like OHSS, higher order multiple pregnancy and increased cost also. Many oocytes are discarded during various stages of laboratory procedures of IVF.2 The primary aim of IVF treatment is to achieve a live birth at term. So the critical question remains that how many mature oocytes per stimulation cycle is most suitable to achieve a live birth with low risk of complications.Many studies have focused on the relation between oocyte number and clinical pregnancies and have shown conflicting results. Some studies have analyzed the relation in between number of oocytes and live birth rate in fresh transfer.1 Our study is to determine the association in between the number of oocytes retrieved and a live birth ABSTRACT Background: There is a strong association between the number of eggs and clinical pregnancy rates in IVF. But a few studies have shown conflicting results. Aim was to determine the relation between number of mature eggs retrieved and live birthrate in one complete IVF cycle (fresh and all frozen transfers included) and hence determine the optimum number of oocytes. Setting private IVF centre doing around 2000 cycles per year. Methods: Retrospective analysis of 1140 infertile women between 20 and 45 years who underwent self-stimulation IVF in our centre, primary outcome studied was cumulative live birth rate in one complete IVF cycle. Secondary outcome was the number of cases of moderate and severe OHSS. Results: Maximum LBR in patients where 10-15 egg were retrieved in fresh embryo transfer and cumulative LBR was maximum when more than 15 eggs were retrieved. No case of severe OHSS and one case of moderate OHSS in the group where more than 15 eggs were retrieved. Conclusions: The percentage of live birth increases with increasing number of mature eggs in IVF treatment. The incidence of OHSS was negligible.

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Estradiol production during controlled ovarian hyperstimulation correlates with treatment outcome in women undergoing in vitro fertilization–embryo transfer

Cited by 75 publications

References 55 publications

Association Between Serum Estradiol Level on the Day of hCG Administration and IVF–ICSI Outcome

Association Between Serum Estradiol Level on the Day of hCG Administration and IVF–ICSI Outcome

Triggering final oocyte maturation with gonadotropin-releasing hormone agonist (GnRHa) versus human chorionic gonadotropin (hCG) in breast cancer patients undergoing fertility preservation: an extended experience

Correlation between number of mature eggs retrieved and live birth rate in IVF treatment

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