Estradiol suppresses ingestive response evoked by activation of 5-HT1A receptors in the lateral hypothalamus of ovariectomized rats

Taschetto, Ana Paula Dambros; Levone, Brunno Rocha; Kochenborger, Larissa; Silva, Eduardo S. da; Flores, Rafael; Faria, Moacir Serralvo; Paschoalini, Marta Aparecida

doi:10.1097/fbp.0000000000000391

Cited by 2 publications

(1 citation statement)

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“…Of course, dissecting the ways in which palatability-related behavior changes across estrous phases is a non-trivial problem, because rodents cycle fast—each phase lasts approximately 1 day. One way to deal with this technical difficulty would be to perform tests on ovariectomized rats, such that circulating estradiol levels can be determined by experimenter injection (Taschetto et al, 2018; Yoest et al, 2019; Yokota-Nakagi et al, 2022). We have chosen not to use this technique here, because while it allows nominal control of estradiol levels (in isolation of other sex-specific hormones), it is difficult to be sure that one is administering the hormone of interest at naturalistic concentrations (studies tend to involve estradiol injections in the vicinity of 5µg/0.1mL, versus natural fluctuations between 2-50pg/mL across the cycle; see for instance Yoest et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Changes in taste palatability across the estrous cycle are modulated by hypothalamic estradiol signaling

Stone,

Rahamim,

Katz

et al. 2024

Preprint

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Food intake varies across the stages of a rat's estrous cycle. It is reasonable to hypothesize that this cyclic fluctuation in consumption reflects an impact of hormones on taste palatability/preference, but evidence for this hypothesis has been mixed, and critical within-subject experiments in which rats sample multiple tastes during each of the four main estrous phases (metestrus, diestrus, proestrus, and estrus) have been scarce. Here, we assayed licking for pleasant (sucrose, NaCl, saccharin) and aversive (quinine-HCl, citric acid) tastes each day for 5-10 days while tracking rats' estrous cycles through vaginal cytology. Initial analyses confirmed the previously-described increased consumption of pleasant stimuli 24-48 hours following the time of high estradiol. A closer look, however, revealed this effect to reflect a general magnification of palatability -- higher than normal preferences for pleasant tastes and lower than normal preferences for aversive tastes -- during metestrus. We hypothesized that this phenomenon might be related to estradiol processing in the lateral hypothalamus (LH), and tested this hypothesis by inhibiting LH estrogen receptor activity with ICI182,780 during tasting. Control infusions replicated the metestrus magnification of palatability pattern; ICI infusions blocked this effect as predicted, but failed to render preferences "cycle free," instead delaying the palatability magnification until diestrus. Clearly, estrous phase mediates details of taste palatability in a manner involving hypothalamic actions of estradiol; further work will be needed to explain the lack of a flat response across the cycle with hypothalamic estradiol binding inhibited, a result which perhaps suggests dynamic interplay between brain regions or hormones.

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Section: Introductionmentioning

confidence: 99%

Changes in taste palatability across the estrous cycle are modulated by hypothalamic estradiol signaling

Stone,

Rahamim,

Katz

et al. 2024

Preprint

View full text Add to dashboard Cite

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The effect of vortioxetine on faecal microbiota in high‐fat diet‐exposed mice—A link to weight protection

Corfitsen,

Bilde,

Rerup

et al. 2024

Basic Clin Pharma Tox

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ObjectiveWeight gain is a common side effect of antidepressive treatment, causing distress among patients and caretakers as it can lead to treatment discontinuation and complications such as diabetes type II and cardiovascular disease. Vortioxetine is one of the newer antidepressants and the pharmacodynamics differ from the selective serotonin reuptake inhibitors. It is marketed as being weight neutral; however, there is little evidence as to why. In recent years, there has been an increased focus on the faecal microbiota and its impact on body weight and mental and physical health. In the current work, we examine the effect of vortioxetine on weight gain and faecal microbiota composition.MethodsForty male C57BL/6NTac mice were primed for 8 weeks with a high‐fat diet (Hfd) or control diet (Cd), followed by a 4‐week period on the same diet and additional +/− vortioxetine 10 mg/kg/daily.ResultsVortioxetine reduced Hfd‐induced weight gain (Hfd + V: 8.2%, Hfd − V: 12.7%; p = 0.0374) but did not affect weight gain of the control group (Cd + V: 7.54%, Cd − V: 7.56%; p = 0.4944). Significant differences in faecal microbiota were observed in mice who received vortioxetine.ConclusionVortioxetine caused significant changes to the faecal microbiota composition and appeared to limit Hfd‐induced weight gain.

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Estradiol suppresses ingestive response evoked by activation of 5-HT1A receptors in the lateral hypothalamus of ovariectomized rats

Cited by 2 publications

References 49 publications

Changes in taste palatability across the estrous cycle are modulated by hypothalamic estradiol signaling

Changes in taste palatability across the estrous cycle are modulated by hypothalamic estradiol signaling

The effect of vortioxetine on faecal microbiota in high‐fat diet‐exposed mice—A link to weight protection

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