Estradiol Therapy After Menopause Mitigates Effects of Stress on Cortisol and Working Memory

Herrera, Alexandra Ycaza; Hodis, Howard N.; Mack, Wendy J.; Mather, Mara

doi:10.1210/jc.2017-00825

Cited by 40 publications

(32 citation statements)

References 45 publications

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“…We evaluated the mental health of women healthcare professionals in the UAE using an objective and reliable tool (salivary cortisol levels) to measure stress, as well as subjective psychological measures of stress and sleep quality. [28][29][30] Importantly, we found that a considerable number of women healthcare professionals had an impaired response to stress and demonstrated abnormal cortisol levels, particularly those working night shift and with longer shift duration. Chronic stress has been linked to the onset of mental health problems and overall poorer physical status in working women, [31][32][33] potentially leading to poor physical and social health, and suboptimal performance at work.…”

Section: Discussionmentioning

confidence: 65%

<p>Salivary Cortisol, Subjective Stress and Quality of Sleep Among Female Healthcare Professionals</p>

Bani‐Issa¹,

Radwan²,

Al-Marzooq³

et al. 2020

JMDH

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Background: Stress is globally recognised as a risk factor impacting workers' health and workplace safety. Women healthcare professionals are at risk for considerable stress given the demanding nature of their jobs and current working conditions. This study assessed levels of stress among women healthcare professionals using measures of their cortisol levels, subjective stress and quality of sleep. Participants and Methods: This study used a cross-sectional design. Data were collected from 335 apparently healthy adult women healthcare professionals working in the United Arab Emirates. Participants provided morning and bedtime saliva samples for analysis of their cortisol levels. The Perceived Stress Scale, Stress Symptoms Scale, Brief Coping Scale and Pittsburgh Sleep Quality Index were used to assess perceived stress level, symptoms of stress, stress-coping strategies and sleep quality, respectively. Results: In total, 121 (36.15%) women had impaired morning cortisol levels (below the normal range of 0.094-1.551 µg/dL) and 48 (14.3%) had impaired bedtime cortisol levels (above 0.359 µg/dL). Around 57% of women reported moderate levels of perceived stress, with the most frequently reported stress symptoms being heart rate and back/neck pain. Poor sleep quality was reported by around 60% of participating women. No significant association was found between cortisol and psychosocial measurements of stress or sleep quality. However, night shift and longer shift duration (more than 8 hrs) were significantly associated with impaired morning and bedtime cortisol levels (P ≥ 0.05). Impaired cortisol levels were strongly dependent on using adaptive coping strategies such as active coping, acceptance and seeking emotional support (P ≥ 0.05). Conclusion: Evaluating cortisol levels and subjective stress could help to identify groups with impaired response to stress and elevated cortisol levels. Our findings support the need to examine shift work patterns and stress coping strategies in women healthcare professionals to promote their health and productivity and maintain workplace safety.

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Section: Discussionmentioning

confidence: 65%

<p>Salivary Cortisol, Subjective Stress and Quality of Sleep Among Female Healthcare Professionals</p>

Bani‐Issa¹,

Radwan²,

Al-Marzooq³

et al. 2020

JMDH

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“…Moreover, concerning dementia, some papers have found benefits of this treatment to the brain, such as the Cache County prospective study, which analyzed 5,677 women and found a correlation between a lower risk of Alzheimer's disease and this hormonal therapy, especially when medication was taken for more than 10 years [9]. The same was described by Herrera et al [10]. Beneventi et al [11] stressed the importance of keeping in mind the negative long-time effects of female hormone absence, namely regarding vaginal dryness, urinary tract infections and dyspareunia.…”

Section: Introductionmentioning

confidence: 67%

“…This is in accordance with the position statement of the North American Menopause Society [7], which says that the risk of breast cancer is rare while on gonadal steroids. This population has high levels of anxiety and depression and, as such, we cannot miss the serotonergic action that estradiol has on the brain [10], which may provide the patients with better mental health. Some sleep disturbances might ameliorate with progesterone, which has sedating effects without affecting daytime cognitive functions [7].…”

Section: Resultsmentioning

confidence: 99%

“…The median age at diagnosis was 44 years (41-51) and the median age at treatment onset was 46 years (42-59). They underwent treatment during a median period of 10 years (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). All data concerning this cohort is explained in Tables 1 and 2.…”

Section: Methodsmentioning

confidence: 99%

“…In certain cases, after allogeneic BMT, graft-versus-host disease requires a long process composed of a series of treatments, which are themselves stressing. Herrera et al [10] show the action of protective estradiol in certain types of cognition, when in the presence of stress. In accordance with their point of view, some of the patients in this study who received brain radiotherapy, and are thus more prone to developing cognition deficiencies, will benefit from HRT.…”

Section: Breast Cancermentioning

confidence: 99%

See 2 more Smart Citations

Is Gonadal Therapy a Promoter of Breast Cancer? Incidence of Breast Cancer in a Cohort of Survivors of Oncological Diseases Treated with Gonadal Steroids

et al. 2020

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There is a great controversy about hormonal replacement therapy in women among the members of the scientific community. Cancer survivors have sometimes had their ovary function totally or partially destroyed, thus affecting their development and quality of life. In this study, we were looking for adverse effects caused, eventually, by estroprogestative therapy in a cohort of supplemented survivors. The occurrence of breast cancer was our main concern. Ours is a retrospective study based on the clinical records of 174 survivors of several cancer diseases. Their median ages within each of the following time frames were: diagnosis -22 years old; start of endocrine treatment -26 years old, and duration of treatment -12 years old. Evaluation was composed of breast cancer assessment, osteopenia and osteoporosis incidence, and vascular events. We have found a very low incidence of breast cancer as well as of vascular events. After treatment, a high percentage of our sample displayed bone mass improvement.

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Estrogen, brain structure, and cognition in postmenopausalwomen

Boyle

Raji

Erickson

et al. 2020

Human Brain Mapping

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Declining estrogen levels before, during, and after menopause can affect memory and risk for Alzheimer's disease. Undesirable side effects of hormone variations emphasize a role for hormone therapy (HT) where possible benefits include a delay in the onset of dementia-yet findings are inconsistent. Effects of HT may be mediated by estrogen receptors found throughout the brain. Effects may also depend on lifestyle factors, timing of use, and genetic risk. We studied the impact of self-reported HT use on brain volume in 562 elderly women (71-94 years) with mixed cognitive status while adjusting for aforementioned factors. Covariate-adjusted voxelwise linear regression analyses using a model with 16 predictors showed HT use as positively associated with regional brain volumes, regardless of cognitive status. Examinations of other factors related to menopause, oophorectomy and hysterectomy status independently yielded positive effects on brain volume when added to our model. One interaction term, HTxBMI, out of several examined, revealed significant negative association with overall brain volume, suggesting a greater reduction in brain volume than BMI alone. Our main findings relating HT to regional brain volume were as Christina P. Boyle and Cyrus A. Raji contributed equally to this work.

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Estradiol Therapy After Menopause Mitigates Effects of Stress on Cortisol and Working Memory

Abstract: We present evidence suggesting ET may protect certain types of cognition in the presence of stress. Such estrogenic protection against stress hormone exposure may prove beneficial to both cognition and the neural circuitry that maintains and propagates cognitive faculties.

Cited by 40 publications

References 45 publications

<p>Salivary Cortisol, Subjective Stress and Quality of Sleep Among Female Healthcare Professionals</p>

<p>Salivary Cortisol, Subjective Stress and Quality of Sleep Among Female Healthcare Professionals</p>

Is Gonadal Therapy a Promoter of Breast Cancer? Incidence of Breast Cancer in a Cohort of Survivors of Oncological Diseases Treated with Gonadal Steroids

Estrogen, brain structure, and cognition in postmenopausalwomen

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