The Amazon rainforest, spanning multiple countries in South America, is the world’s largest equatorial expanse, housing a vast array of relatively unknown plant and animal species. Encompassing the planet’s greatest flora, the Amazon offers a tremendous variety of plants from which natural lignocellulosic fibers (NLFs) can be extracted. In this century, NLFs, which have long been utilized by indigenous populations of the Amazon, have garnered interest as potential reinforcements for composites, whether polymer- or cement-based, in various technical applications such as packaging, construction, automotive products, and ballistic armor. A comparison with synthetic materials like glass, carbon, and aramid fibers, as well as other established NLFs, highlights the cost and specific property advantages of Amazon natural fibers (ANFs). Notably, the sustainable cultivation and extraction of ANFs, as alternatives to deforestation and livestock pasture, contribute to the preservation of the Amazon rainforest. This review article provides a comprehensive examination of recent studies directly related to ANF-reinforced polymer matrix composites. The specific advantages, proposed applications, and reported challenges are highlighted, shedding light on the potential of these unique natural fibers.