ESTRIP, a BASIC Computer Program for Obtaining Initial Polyexponential Parameter Estimates

Brown, Ronald D.; Manno, Joseph E.

doi:10.1002/jps.2600671214

Cited by 318 publications

(99 citation statements)

References 2 publications

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“…Coefficients and exponents of the disposition curves that best described the changes in plasma erythromycin concentrations were calculated by iterative least squares non-linear regression analysis, using the ESTRIP computer program (Brown & Manno, 1978). Area under the curve (AUC) was determined by the trapezoidal method and by using the calculated polyexponential equation to infinity.…”

Section: Bioassaymentioning

confidence: 99%

Comparison of oral erythromycin formulations in the horse using pharmacokinetic profiles

Ewing

Burrows

MacAllister

et al. 1994

Vet Pharm & Therapeutics

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Ewing, P. J., Burrows, G., MacAllister, C, Clarke, C. Comparison of oral erythromycin formulations in the horse using pharmacokinetic profiles. J. vet. Pharmacol, Therap.17, 17–23. The pharmacokinetic properties of four erythromycin formulations were compared in six adult horses after administration of single and multiple oral doses. Formulations of erythromycin administered were estolate and phosphate given 37.5 mg/kg every 12 h and 25 mg/kg every 8 h, and stearate and ethylsuccinate given 25 mg/kg every 8 h. Areas under the curve (AUC) and maximum plasma erythromycin concentrations (Cmax) were equal or greater (P ≥ 0.05) following administration of erythromycin phosphate and stearate compared with those values following administration of erythromycin estolate or ethylsuccinate. In comparing an 8 h vs. a 12 h dosage interval for multiple doses of erythromycin phosphate or estolate, there were no significant differences observed in AUC(24–28 h), peak‐trough plasma concentrations or duration that plasma concentrations exceeded the minimal inhibitory concentration (MIC) for Rhodococcus equi. Comparisons of pharmacokinetic parameters between single and multiple doses were made for each formulation. Differences in Cmax, tmax, or t½β between single and multiple doses were demonstrated for erythromycin ethylsuccinate and estolate. Based on equivalent plasma antibiotic concentrations, erythromycin phosphate or stearate could be substituted for estolate in the treatment of Rhodococcus equi pneumonia. Furthermore, there was no advantage of an 8‐h interval, compared with an interval of 12 h.

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Section: Bioassaymentioning

confidence: 99%

Comparison of oral erythromycin formulations in the horse using pharmacokinetic profiles

Ewing

Burrows

MacAllister

et al. 1994

Vet Pharm & Therapeutics

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“…Further, k a stands for absorption time constant, and a and b for distribution and elimination time constants. The pharmacokinetic parameters were estimated using a non-linear, least squares curve fitting program ESTRIP (Brown & Manno 1987) modified by one of the authors (KM). The programme uses an exponential stripping method for initial parameter estimates, and it has been validated with the commercially available programs PCNONLIN (Metzler & Weiner 1989) and TopFit (Heinzel et al 1993).…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of Chlorambucil in Patients with Chronic Lymphocytic Leukaemia: Comparison of Different Days, Cycles and Doses

Silvennoinen¹,

Malminiemi²,

Malminiemi³

et al. 2000

Pharmacology & Toxicology

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The effects of repeated treatment cycles and different doses on intraindividual variation in oral bioavailability of chlorambucil and its first, active, and more toxic metabolite, phenylacetic acid mustard, were studied. Chlorambucil and phenylacetic acid mustard concentrations were measured with HPLC on Day 1 and on Day 4 in 15 timed blood samples from 11 chronic lymphocytic leukaemia patients receiving chlorambucil therapy cycles. Bioavailability was evaluated also after the first chlorambucil doses of six consecutive treatment cycles repeated every 4 weeks with increasing chlorambucil doses starting with 0.8 mg/kg/4 days, and increased by 0.1 mg/kg/4 days cycle. Area under the concentrationtime-curve (AUC) from tΩ0 to infinite was in average 3.2 hr*mg/ml for the first cycle, and decreased by 17% in four days (PϽ0.05). The mean distribution half-life of chlorambucil was 0.49 hr and the terminal elimination half-life 2.45 hr. The bioavailability of chlorambucil decreased further when 4-day treatment cycles were repeated. For the fifth cycle, dosecorrected AUC for the first 2 hr was 33% smaller than that for the first cycle (P for trend Ͻ0

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“…Plasma oxazepam concentrations were analyzed by the ESTRIP program for kinetic studies (Brown et al, 1978 (Wulff & Schlichting, 1988). 5% was chosen as the level of significance.…”

Section: Pharmacodynamic Studymentioning

confidence: 99%

Single dose pharmacokinetics and pharmacodynamics of oral oxazepam during concomitant administration of propranolol and labetalol.

Sonne

Døssing

Loft

et al. 1990

Brit J Clinical Pharma

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1 The oral kinetics of oxazepam after a single 15 mg oral dose was investigated in six healthy volunteers before and during concomitant administration of the ,-adrenoceptor antagonists propranolol (80 mg) and labetalol (200 mg) (racemates). 2 A possible pharmacodynamic interaction between oxazepam and the 13-adrenoceptor antagonists was examined using a simple reaction time test (SRT) and by measurement of postural sway. 3 The kinetics of oxazepam were not affected significantly by propranolol or labetalol, although oxazepam and labetalol share the glucuronidation pathway.4 The SRT was increased by combination of both 0-adrenoceptor antagonists with oxazepam, with the greatest increase after the coadministration of oxazepam with propranolol. Administration of the P-adrenoceptor antagonists alone had no significant effect. 5 Postural sway was affected significantly only by the combination of oxazepam and propranolol.

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ESTRIP, a BASIC Computer Program for Obtaining Initial Polyexponential Parameter Estimates

Cited by 318 publications

References 2 publications

Comparison of oral erythromycin formulations in the horse using pharmacokinetic profiles

Comparison of oral erythromycin formulations in the horse using pharmacokinetic profiles

Pharmacokinetics of Chlorambucil in Patients with Chronic Lymphocytic Leukaemia: Comparison of Different Days, Cycles and Doses

Single dose pharmacokinetics and pharmacodynamics of oral oxazepam during concomitant administration of propranolol and labetalol.

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