Estrogen adversely affects the prognosis of patients with lung adenocarcinoma

Hsu, Li‐Han; Liu, Ko Jiunn; Tsai, Ming Fang; Wu, Chang Ru; Feng, An Chen; Chu, Nei Min; Kao, Shu Huei

doi:10.1111/cas.12558

Cited by 54 publications

(42 citation statements)

References 45 publications

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“…It is known that oestrogen (E2) elicits a stronger immune reaction than testosterone, and the immunoregulatory effect of E2 contributes to the susceptibility of women to AIDs . In addition, accumulating evidence has shown that OPN production is E2‐dependent, which further supports the concept that E2 can modulate OPN bioactivity . Despite there being no significant difference in OPN levels between women and men in GD, we believe that E2 might still modify OPN's function at a certain level, and subsequently facilitate OPN production, and contribute to GD development and promote a stronger association of OPN levels with TSHRAb levels and thyroid function in women than in men.…”

Section: Discussionsupporting

confidence: 55%

Synchronized expressions of serum osteopontin and B cell–activating factor in autoimmune thyroid disease

Cheng

Tang

Fang

et al. 2019

Eur J Clin Investigation

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Background Osteopontin (OPN) is recognized as a potent immunoregulator of autoimmune disease. In the study, we tried to explore the association of serum OPN levels with autoimmune thyroid disease, including Graves' disease (GD) and Hashimoto's thyroiditis (HT), in an ethnic Chinese population. Materials and methods We enrolled 131 patients with GD, 33 patients with HT and 123 healthy controls. Serum OPN, B cell–activating factor (BAFF) and interferon (IFN)‐α levels were quantified. Graves' disease patients with high thyroid function at the time of sample collection were defined as having active GD, while the other patients were defined as having inactive GD. Results Serum OPN levels were higher in active GD than in inactive GD and the control groups (P = 0.001 and P = 0.018, respectively). In GD, significant associations of OPN levels with thyroid‐stimulating hormone receptor antibody (TSHRAb) levels were observed in women (r = −0.344, P = 0.002, and r = 0.440, P = 0.004, respectively) but not in men. Osteopontin levels were associated with BAFF levels only in women with GD or HT (r = 0.506, P < 0.001 and r = 0.430, P = 0.025, respectively), but not in men with GD or HT. Conclusions Serum OPN levels were upregulated in active GD, and serum OPN levels were associated with thyroid function and TSHRAb levels in GD. Additionally, OPN levels were correlated with BAFF levels in GD and HT. The associations of OPN levels with clinical phenotypes of GD and BAFF levels showed a dimorphic pattern.

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Section: Discussionsupporting

confidence: 55%

Synchronized expressions of serum osteopontin and B cell–activating factor in autoimmune thyroid disease

Cheng

Tang

Fang

et al. 2019

Eur J Clin Investigation

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“…Therefore, FRBI interfered with FSH-FSHR interaction leading to a blockage of FSH action [3]. Currently, little information has been recorded about FRBI effects on follicular development and reproduction functions in human and animals [2, 13]. In the present study, different doses of FRBI were added into the IVM medium for sheep COCs so as to assess FRBI effects on IVM and apoptosis of sheep COCs.…”

Section: Discussionmentioning

confidence: 99%

“…These signaling cascades adjusted by FSH and LH in the granulosa cells play a crucial role in follicular development and ovulation [11]. However, the exact mechanism of FRBI actions remains still unclear and the regulatory signaling pathways are undetermined [2, 12, 13]. IP3 is an important intracellular second messenger that participates in signal transduction pathways in diverse cell types.…”

Section: Introductionmentioning

confidence: 99%

FSHR and LHR Expression and Signaling as Well as Maturation and Apoptosis of Cumulus-Oocyte Complexes Following Treatment with FSH Receptor Binding Inhibitor in Sheep

Wei

Shen

Gong

et al. 2017

Cell Physiol Biochem

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Background/Aims: Currently, it remains unknown whether FSH receptor binding inhibitor (FRBI) influences follicular development and reproduction functions in humans and animals. The present study aimed to investigate FRBI effects on in vitro maturation (IVM) and apoptosis of cumulus-oocyte complexes (COCs) of sheep, to determine the effect of FRBI on mRNA and protein levels of FSHR and LHR in COCs, and to elucidate the signal pathway of FRBI effects. Methods: COCs were in vitro cultured for 24h in the IVM media supplemented with varying concentrations of FRBI (0, 10, 20, 30 and 40µg/mL) and FSH (10IU/mL). The harvested COCs were observed under an inverted microscope and maturation rates of COCs were determined. Real time RT-PCR and Western blotting were utilized to detect mRNA and protein levels of FSHR and LHR. The concentrations of FSH, LH and caspase-3 were determined using especial ELISA kits for sheep, respectively. Results: Maturation rates of COCs decreased gradually as FRBI concentrations increased from 0 to 40µg/mL, reaching a bottom value of 23.76% of the FRBI-4 group. The maximal apoptosis rate was detected in the FRBI-4 group. IP3 contents of FRBI-3 and FRBI-4 groups were reduced as compared to control group (CG) and FSH groups (P<0.05). Levels of FSHR protein of FRBI-3 and FRBI-4 groups as well as LHR protein of FRBI-4 group were significantly less than that of CG and FSH group. FSH contents of four FRBI treatment groups were gradually decreased along with the supplementation doses of FRBI. Caspase-3 contents of FRBI groups were reduced with a maximum reduction of the FRBI-2 group. Conclusion: Our results revealed supplement of FRBI into IVM media could dose-dependently decrease the maturation rate and increase apoptosis rate of sheep COCs. A lower dose of FRBI treatment slightly promoted IP3 production, but a higher dose of FRBI reduced IP3 production. FRBI suppressed the mRNA and protein expression levels of FSHR and LHR in sheep COCs. Our study will help to therapy effectively ovarian diseases, improve ovarian and follicular functions, and further to promote fertility of humans and animals.

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“…Estrogen is thought to play an important role in carcinogenesis in some carcinomas. One laboratory study demonstrated that estrogen upregulates osteopontin expression and promotes cancer cell migration via estrogen receptor beta (ERβ) activation in the MEK/ERK signaling pathway (17). Furthermore, Hsu et al (18) evaluated gender-associated differences on survival in non-smoker patients with lung adenocarcinoma and noted that elderly women had a more favorable survival outcome than elderly males.…”

Section: Discussionmentioning

confidence: 99%

Patient age was an independent predictor of cancer-specific survival in male patients with upper tract urothelial carcinoma treated by radical nephroureterectomy

Kobayashi

Kikuchi

Tanaka

et al. 2016

Japanese Journal of Clinical Oncology

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Objective: We hypothesized that there may be a prognostic difference in age between the genders and evaluated the influence of gender-adjusted age on prognosis in upper tract urothelial carcinoma patients. Methods: A total of 839 patients with upper tract urothelial carcinoma from a retrospective multiinstitutional cohort were included. The patients were divided into four groups consisting of males (N = 610) and females (N = 229) according to age ((i) <60 years, (ii) 60-69.9 years, (iii) 70-79.9 years and (iv) ≥80 years), and we evaluated the associations of patient age and gender with clinicopathological features and oncological outcomes following radical nephroureterectomy. The median follow-up duration was 34 months. Results: Disease recurrence occurred in 249 patients and 192 patients died of upper tract urothelial carcinoma. The 3-year cancer-specific survival rates were (i) 84.3%, (ii) 80.2%, (iii) 77.1% and (iv) 71.5% in the entire patient population (P = 0.001); (i) 84.5%, (ii) 81.1%, (iii) 76.8% and (iv) 69.7% in males (P = 0.010); and (i) 83.3%, (ii) 76.9%, (iii) 77.7% and (iv) 72.9% in females (P = 0.287), respectively. No significant differences between disease recurrence and age were found in the male or female population. In multivariate analysis, older age was an independent predictor of cancer-specific survival, in addition to advanced pT stage, the presence of lymphovascular invasion and lymph node involvement in males. In contrast, age was not associated with cancer-specific survival in females, while high grade, advanced pT stage, the presence of lymph node involvement and multifocal tumor were independent predictors. Conclusion: The results indicate that gender-adjusted age might be a new prognostic factor in upper tract urothelial carcinoma patients.

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Estrogen adversely affects the prognosis of patients with lung adenocarcinoma

Cited by 54 publications

References 45 publications

Synchronized expressions of serum osteopontin and B cell–activating factor in autoimmune thyroid disease

Synchronized expressions of serum osteopontin and B cell–activating factor in autoimmune thyroid disease

FSHR and LHR Expression and Signaling as Well as Maturation and Apoptosis of Cumulus-Oocyte Complexes Following Treatment with FSH Receptor Binding Inhibitor in Sheep

Patient age was an independent predictor of cancer-specific survival in male patients with upper tract urothelial carcinoma treated by radical nephroureterectomy

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