Estrogen and Castration-Induced Effects on Canine Prostatic Fine Structure and Ci9-steroid Metabolism

Leav, Irwin; Morfin, Robert; Ofner, P.; Cavazos, L. F.; Leeds, E. B.

doi:10.1210/endo-89-2-465

Cited by 71 publications

(26 citation statements)

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“…Since dihydrotestosterone can be converted to androstanediol in the prostate (18), it is surprising that androstanediol promotes prostatic growth more efficiently than dihydrotestosterone itself. The dog prostate contains both 3a-and 3fi-hydroxysteroid oxidoreductases (18), and it is possible that the unique feature of the 3a (as contrasted to the 3P) androstanediol is that it circumvents the formation of the 3P derivative, which does not promote growth of the rat prostate (19). Pharmacological doses of hormones have been utilized in the present study, and it will be necessary to determine whether prostate growth can be induced by physiological doses.…”

Section: Discussionmentioning

confidence: 99%

The induction of prostatic hypertrophy in the dog with androstanediol.

Walsh¹,

Wilson²

1976

J. Clin. Invest.

416

157

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Section: Discussionmentioning

confidence: 99%

The induction of prostatic hypertrophy in the dog with androstanediol.

Walsh¹,

Wilson²

1976

J. Clin. Invest.

416

157

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“…2) Testosterone is principally metabolized by the prostatic enzyme A4-3-ketosteroid-5a-oxidoreductase (50-reduc tase) to 5a-dihydrotestosterone (5a-DHT) which appar ently is the principal androgenic hormone in rodent [5. 12], canine [20] and human [3. 22] prostate.…”

Section: Steroid-hormone Regulation Of Prostate Epithelial Cell Functionmentioning

confidence: 99%

Prostate Carcinogenesis in the AXC Rat

Shain¹,

McCullough²,

Nitchuk³

et al. 1977

Oncology

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The ventral prostate of the aging rat is characterized by decreased cytoplasmic and nuclear androgen receptor content, diminished capacity to synthesize 5α-dihydrotestosterone, increased capacity to synthesize ▵⁴-androstenedione and diminished dependence on androgen for maintenance of cell number. By contrast, the dorsolateral prostate of the aging rat does not contain demonstrable cytoplasmic androgen receptor, is characterized by diminished nuclear androgen receptor content, an unchanged capacity to synthesized 5α -dihydrotestosterone, a moderately increased capacity to synthesize ▵⁴-androstenedione and cell number is markedly androgen independent throughout adulthood. Spontaneous adenocarcinomas of the ventral prostate were detected with a frequency of 70 % in aged (30 to 46 month old), virgin male AXC rats, whereas the dorsolateral prostate did not contain any spontaneous adenocarcinomas. The tumors were transplantable to isogenic recipients and three transplantable tumors have been obtained. Testosterone metabolism by primary and transplantable adenocarcinomas demonstrates progressively diminished 5α-dihydrotestosterone synthetic capacity and increased ▵⁴-androstenedione synthetic capacity. The data suggests that the aging-associated changes in androgen metabolism and regulation of cell number in ventral prostate may be related to the development of prostate adenocarcinoma.

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“…The adminis tration of E2, however, caused little or no inhibition of 5a-reduction of T in dog [9] and rat ventral prostates [3,26], but did stimulate the formation of products of the oxidative path way relative to 5«-reduced metabolites. On the other hand, 5a-RA was inhibited in the dorsolateral prostate of E2-treated rats [26].…”

Section: Discussionmentioning

confidence: 86%

5α-Reductase as a Target Enzyme for Anti-Prostatic Drugs in Organ Culture

Kadohama¹,

Kirdani²,

Murphy³

et al. 1977

Oncology

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Short-term organ culture of rat and human prostatic tissues has been utilized as a means of testing drugs potentially useful in cancer of the prostate. Optimal conditions, particularly the concentration of T, have been established for organ culture of such tissues and the effects of various drugs on 5α-reductase activity (5α-RA) have been utilized as a means of ascertaining antiprostatic actions of the various compounds and drugs tested. Thus, it was shown that estracyt, estradiol-17β, progesterone, and novel steroids and steroid-conjugates have definite effects on 5α-RA in this system.

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Estrogen and Castration-Induced Effects on Canine Prostatic Fine Structure and Ci9-steroid Metabolism

Cited by 71 publications

References 0 publications

The induction of prostatic hypertrophy in the dog with androstanediol.

The induction of prostatic hypertrophy in the dog with androstanediol.

Prostate Carcinogenesis in the AXC Rat

5α-Reductase as a Target Enzyme for Anti-Prostatic Drugs in Organ Culture

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