Estrogen and Comprehension of Metaphoric Speech in Women Suffering From Schizophrenia: Results of a Double-Blind, Placebo-Controlled Trial

Bergemann, Niels; Parzer, Peter; Auler, Beatrice; Maier-Braunleder, Sabine

doi:10.1016/s0920-9964(08)70754-0

Cited by 4 publications

(6 citation statements)

References 57 publications

(69 reference statements)

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“…The same authors [33] could furthermore show a significant effect of estrogen on the comprehension of metaphoric speech and/or concretism, a main feature of schizophrenic thought and language disturbance. Ko et al [34] similarly found that 35 women with chronic schizophrenia and related psychoses had low levels of estrogen which was associated with severe negative symptomatology and reduced cognitive functioning, especially in the domains of verbal performance and executive tasks.…”

Section: Clinical Findingsmentioning

confidence: 80%

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Riecher-Rössler¹,

Kulkarni

2010

Biological Basis of Sex Differences in Psychopharmacology

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Section: Clinical Findingsmentioning

confidence: 80%

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Riecher-Rössler¹,

Kulkarni

2010

Biological Basis of Sex Differences in Psychopharmacology

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“…The few behavioral studies including patients with schizophrenia have suggested that these patients have deficits in the comprehension of communicative gestures [Berndl et al, 1986;Bucci et al, 2008;Grü sser et al, 1990;Matthews et al, 2011]. Further, patients exhibit problems with the understanding of abstract sentences, clinically termed ''concretism'' [Bergemann et al, 2008;Iakimova et al, 2010;Kircher et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

Neural integration of speech and gesture in schizophrenia: Evidence for differential processing of metaphoric gestures

Straube¹,

Green²,

Saß³

et al. 2012

Human Brain Mapping

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Gestures are an important component of interpersonal communication. Especially, complex multimodal communication is assumed to be disrupted in patients with schizophrenia. In healthy subjects, differential neural integration processes for gestures in the context of concrete [iconic (IC) gestures] and abstract sentence contents [metaphoric (MP) gestures] had been demonstrated. With this study we wanted to investigate neural integration processes for both gesture types in patients with schizophrenia. During functional magnetic resonance imaging-data acquisition, 16 patients with schizophrenia (P) and a healthy control group (C) were shown videos of an actor performing IC and MP gestures and associated sentences. An isolated gesture (G) and isolated sentence condition (S) were included to separate unimodal from bimodal effects at the neural level. During IC conditions (IC > G ∩ IC > S) we found increased activity in the left posterior middle temporal gyrus (pMTG) in both groups. Whereas in the control group the left pMTG and the inferior frontal gyrus (IFG) were activated for the MP conditions (MP > G ∩ MP > S), no significant activation was found for the identical contrast in patients. The interaction of group (P/C) and gesture condition (MP/IC) revealed activation in the bilateral hippocampus, the left middle/superior temporal and IFG. Activation of the pMTG for the IC condition in both groups indicates intact neural integration of IC gestures in schizophrenia. However, failure to activate the left pMTG and IFG for MP co-verbal gestures suggests a disturbed integration of gestures embedded in an abstract sentence context. This study provides new insight into the neural integration of co-verbal gestures in patients with schizophrenia.

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“…Social-communicative dysfunctions in schizophrenia have received increased interest from the field of neuroscience. Patients have been reported to exhibit impairments in the interpretation of abstract speech ("concretism") [6][7][8][9][10][11] as well as in speech-gesture integration [24][25][26][27][28]28,[30][31][32][33][34]60,[114][115][116][117][118]. In particular, patients tend to have problems with integrating abstract speech-gesture combinations [46,47,60], accompanied by aberrations in neural activation [11,46].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with schizophrenia suffer not only from positive symptoms like delusions and hallucinations, but also from speech and language aberrations on all linguistic levels [1][2][3][4]. In particular, patients show difficulties in the understanding of figurative speech or abstract concepts as being conveyed frequently through metaphors [5] (e.g., "out of the blue") which they tend to misinterpret in a concrete way ('concretism') [6][7][8][9][10][11]. The interpretation of metaphors has a tremendous impact on successful social interactions [5,12] and represents a real-world communication problem for patients with schizophrenia [11,13].…”

Section: Introductionmentioning

confidence: 99%

A Novel Multimodal Speech-Gesture Training and Its Impact on Quality of Life and Neural Processing in Patients With Schizophrenia Spectrum Disorder. A Pilot Randomized Controlled Trial

Riedl¹,

Nagels²,

Sammer³

et al. 2021

Preprint

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Introduction: Dysfunctional social communication is one of the most stable characteristics in patients with schizophrenia that severely affects quality of life. Interpreting abstract speech and integrating nonverbal information is particularly affected which has been associated with neural dysfunctions in temporal lobe regions. Objectives: Considering the difficulty to treat communication dysfunctions with usual intervention, we investigated the possibility to improve quality of life and co-verbal gesture processing in patients with schizophrenia by applying a multimodal speech-gesture training (MSG training).Methods: In the MSG training, we offered eight sessions (60 min each) of training including perceptive and expressive tasks as well as meta-learning elements and transfer exercises to 29 patients with schizophrenia spectrum disorder (SSD). Patients were randomized to a waiting-first group (N=20) or a training-first group (N=9), and were compared to healthy controls (N=17). Outcomes were quality of life and related changes in the neural processing of abstract speech-gesture information, which were measured pre-post training through standardized psychological questionnaires and functional Magnetic Resonance Imaging, respectively.Results: Pre-training, patients showed reduced quality of life as compared to controls but improved significantly during the training. Strikingly, this improvement was correlated with neural activation changes in the middle temporal gyrus for the processing of abstract multimodal content. Conclusion: With this study, we provide first promising results of a novel multimodal speech-gesture training for patients with schizophrenia. We could link training induced changes in speech-gesture processing to changes in quality of life, demonstrating the relevance of intact communication skills and gesture processing for well-being.

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Estrogen and Comprehension of Metaphoric Speech in Women Suffering From Schizophrenia: Results of a Double-Blind, Placebo-Controlled Trial

Cited by 4 publications

References 57 publications

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Estrogens and Gonadal Function in Schizophrenia and Related Psychoses

Neural integration of speech and gesture in schizophrenia: Evidence for differential processing of metaphoric gestures

A Novel Multimodal Speech-Gesture Training and Its Impact on Quality of Life and Neural Processing in Patients With Schizophrenia Spectrum Disorder. A Pilot Randomized Controlled Trial

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