Estrogen and hearing from a clinical point of view; characteristics of auditory function in women with Turner syndrome

Hederstierna, Christina; Hultcrantz, Malou; Rosenhall, Ulf

doi:10.1016/j.heares.2008.11.006

Cited by 34 publications

(36 citation statements)

References 29 publications

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“…As previously mentioned, ABR-latencies in the present study were within reference range in all 31 TS cases. In accordance with Hedestierna's study [11], ABR amplitudes and absolute and interpeak latencies of our TS cases were not significantly prolonged compared to the reference population. Up to 50% of TS cases had mild to moderate HL, and three of them (10%) showed an absence of wave I, suggesting a cochlear dysfunction as the cause of their hearing impairment.…”

Section: Discussionsupporting

confidence: 92%

“…Otherwise, the incidence of SNHL increases with old age [9], and comparison should be done with other studies with an age-matched population. Hederstierna et al [11] studied 30 TS women aged 40-67 years, with mild to moderate HL, with the objective of localizing the lesion responsible for the SNHL and assessing central auditory function. As previously mentioned, ABR-latencies in the present study were within reference range in all 31 TS cases.…”

Section: Discussionmentioning

confidence: 99%

“…Two patterns of sensorineural hearing decline in TS patients have been defined: a mid-frequency dip and a high frequency loss resembling age-related hearing impairment (early presbyacusia) [6,9,10]. The pathophysiology of sensorineural lesions is not yet fully understood, it is potentially influenced by oestrogen deficiency [9,11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hearing loss in adult women with Turner’s syndrome and other congenital hypogonadisms

Ros¹,

Tercero²,

Alobid

et al. 2013

Gynecological Endocrinology

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hearing loss in adult women with Turner’s syndrome and other congenital hypogonadisms

Ros¹,

Tercero²,

Alobid

et al. 2013

Gynecological Endocrinology

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“…In a clinical study in which the peripheral and central hearing functions of women with Turner syndrome were assessed, the major hearing loss was due to a peripheral cochlear degeneration (Hederstierna et al 2009). Impairment of spatial learning is present in women with Turner syndrome and this deficiency has also been demonstrated in ER-b K/K mice (Boman et al 1998, Rissman et al 2002.…”

Section: Discussionmentioning

confidence: 99%

Inner ear pathology and loss of hearing in estrogen receptor-β deficient mice

Simonoska¹,

Stenberg²,

Duan

et al. 2009

Journal of Endocrinology

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There are well known differences between males and females in hearing. In the present study, the role of estrogen receptor-b (ER-b; listed as ESR2 in the MGI Database) in hearing was investigated by comparing hearing and morphology of the inner ear in ER-b knock-out mice (ER-b) with that of wild-type (WT) littermates. Hearing was analyzed with auditory brainstem response audiometry at 3 and 12 months. The ER-b K/K mice were deaf at 1 year of age, and the morphological analysis showed absence of hair cells and loss of the whole organ of Corti initiated in the basal turn of the cochlea. Furthermore, in ER-b, but not in WT mice, the spiral ganglion was lacking many of its neurons.Immunostaining showed the presence of both ER-a (listed as ESR1 in the MGI Database) and ER-b in the nuclei of some neurons in the inner ear in WT mice, but no ER-b was found in the ER-b K/K mice as expected. ER-a staining was predominant in the nuclei of large neurons and ER-b in nuclei of small neurons and fibroblasts. These results reveal that both ERs are present in the inner ear at specific localizations suggesting subtype-specific functions. It is concluded that ER-b is important for the prevention of agerelated hearing loss. These findings strengthen the hypothesis that estrogen has a direct effect on hearing functions.

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“…21 SNHL usually begins in the late childhood-early adulthood in a gradually progressive manner. The audiologic pattern often shows a symmetrical dip in the midfrequency range in girls starting as young as 6 years of age.…”

Section: Introductionmentioning

confidence: 99%

Otologic and audiologic features of ethnic Chinese patients with Turner syndrome in Taiwan

Chan¹,

Wang²,

Wu³

et al. 2012

Journal of the Formosan Medical Association

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We found varying degrees of otologic and audiologic abnormalities among the TS in ethnic Chinese population. About one-half of the patients had recurrent OM, which was more likely to be associated with CHL in early life. Therefore, regular surveillance, early diagnosis, and the initiation of appropriate treatment are crucial in improving the hearing and speech in children with TS as well as in preventing short- and long-term associated complications.

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Estrogen and hearing from a clinical point of view; characteristics of auditory function in women with Turner syndrome

Cited by 34 publications

References 29 publications

Hearing loss in adult women with Turner’s syndrome and other congenital hypogonadisms

Hearing loss in adult women with Turner’s syndrome and other congenital hypogonadisms

Inner ear pathology and loss of hearing in estrogen receptor-β deficient mice

Otologic and audiologic features of ethnic Chinese patients with Turner syndrome in Taiwan

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