Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women

Scheid, Jennifer L.; Toombs, Rebecca J.; Ducher, Ga͏ële; Gibbs, Jenna C.; Williams, Nancy I.; Souza, Mary Jane De

doi:10.1016/j.bone.2011.04.011

Cited by 44 publications

(34 citation statements)

References 46 publications

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“…high as 60% [11], and the co-existence of menstrual irregularity and compromised BMD has been repeatedly observed [4,5,[12][13][14][15]. Functional hypothalamic amenorrhea, defined as the absence of menses for greater than 90 days (secondary amenorrhea) [16] or the failure to attain menarche by age 15 (primary amenorrhea) [17] which cannot be explained by other underlying pathology [17], and oligomenorrhea, defined as irregular and inconsistent menses at intervals of 36 to 90 days [16], are the most severe presentations of menstrual cycle disturbances and are linked to poor skeletal health [3,5,8].…”

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confidence: 95%

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Current and past menstrual status is an important determinant of femoral neck geometry in exercising women

Mallinson

Williams

Gibbs

et al. 2016

Bone

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confidence: 95%

“…Substantial evidence demonstrates that female athletes presenting with amenorrhea have significantly lower BMD at the lumbar spine in comparison to their eumenorrheic counterparts [2][3][4][5][12][13][14][15]22]. Less consistently, lower BMD at the femoral neck and/or total hip has also been observed [4,5,14,15].…”

mentioning

confidence: 99%

Current and past menstrual status is an important determinant of femoral neck geometry in exercising women

Mallinson

Williams

Gibbs

et al. 2016

Bone

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“…All of the 45 studies met the selection criteria and were suitable for the meta-analysis [2,. Most of the studies were cross-sectional, including 9 on men [11][12][13][14][15][16][17]33,36], 14 on premenopausal women [2,11,16,[18][19][20][21][22]26,40,43,44,47,53], 27 on postmenopausal women [2,11,12,16,19,22-35,37-39, 48,51,53], 5 on girls [41,42,45,46,49], and only 1 on boys [49]. Pooling the included studies for the COR analyses involved a combined sample size of 7,674 patients (41 boys, 2,965 men, 422 girls, 1,442 premenopausal women, and 2,804 postmenopausal women) across 45 studies.…”

Section: Resultsmentioning

confidence: 99%

Relationship between serum leptin levels and bone mineral density: A systematic review and meta-analysis

Liu

et al. 2015

Clinica Chimica Acta

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“…Russell [140] demonstrated PYY to be negatively associated with lumbar BMD Z scores and a marker of bone formation, serum type 1 procollagen C-terminal/Nterminal (PINP) in adolescent female athletes both with and without amenorrhoea. Moreover, in lean pre-menopausal women, circulating PYY levels were significantly and negatively correlated with total body and hip bone mass, with PYY contributing to 9 % of the variance in BMD of the hip [141]. A single clinical study to date has correlated raised postprandial PYY levels with bone mineral density loss in bariatric surgery patients (Brzozowska MM, Endocrine Reviews 2013: FP09).…”

Section: Potential Mechanisms Of Bone Loss After Bariatric Surgerymentioning

confidence: 99%

Bariatric Surgery and Bone Loss: Do We Need to Be Concerned?

Brzozowska

Sainsbury

Eisman

et al. 2014

Clinic Rev Bone Miner Metab

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Despite significant improvement in weight and comorbid conditions, there is growing evidence that bariatric surgery may exert a negative effect on the skeleton. This review has focused on the impact of bariatric surgery on bone health, with the concern that bariatric surgery may increase skeletal fragility and fracture risk by accelerating bone loss. We have highlighted studies evaluating changes in bone metabolism after three commonly performed bariatric procedures including laparoscopic adjustable gastric banding, Roux-en-Y gastric bypass surgery and increasingly popular sleeve gastrectomy. This review has also discussed some of the technical issues faced in measuring bone in obese populations and during dynamic weight loss. There is limited evidence regarding potential mechanisms for the reported observations of increased bone turnover and/or bone loss after bariatric surgery. We have reviewed the evidence surrounding potential factors affecting bone health in bariatric patients such as rapid weight loss per se, nutritional deficiencies, effects of fat-derived adipokines and gut-derived appetite-regulatory hormones. Future prospective long-term cohort studies are needed to define how to quantify bone loss in individuals with obesity, particularly following massive weight loss, and for how long the bone changes continue. These studies will help clarify any negative clinical consequences of these changes, including future fracture risk in this unique group of patients. IntroductionThe prevalence of obesity worldwide has increased significantly in recent decades because of a complex range of environmental and possibly also epigenetic factors. Obesity is associated with increased mortality [1] with reduced life expectancy, especially amongst people affected from young adulthood [2], as well as multiple comorbidities including type 2 diabetes, hyperlipidemia, sleep apnoea, malignancy and decreased quality of life [3].The medical management of obesity is limited by the variable, limited response to treatment, suboptimal compliance and adverse effects of antiobesity medications. At present, the only effective, long-term treatment for obesity remains bariatric surgery, which results in substantial and sustained weight loss, significant reductions in comorbid conditions, and prolonged longevity [4]. In fact, the utilization of bariatric surgery as a therapeutic approach to morbid obesity has increased two and a half-fold worldwide between 2003 and 2011 [5].Although many studies have demonstrated the short-and long-term efficacy of bariatric surgery for weight loss, there are limited data regarding any long-term side effects of these procedures. Recently, there has been an increased focus on the impact of bariatric surgery on bone metabolism, with the concern that bariatric surgery may increase skeletal fragility and fracture risk by accelerating bone loss.The majority of research performed in this area has been cross-sectional and provides little evidence as to the possible mechanisms for any observed abnormal...

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Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women

Cited by 44 publications

References 46 publications

Current and past menstrual status is an important determinant of femoral neck geometry in exercising women

Current and past menstrual status is an important determinant of femoral neck geometry in exercising women

Relationship between serum leptin levels and bone mineral density: A systematic review and meta-analysis

Bariatric Surgery and Bone Loss: Do We Need to Be Concerned?

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