Estrogen and progesterone receptor content of primary and secondary breast carcinoma: Influence of time and treatment

Mobbs, B.G.; Fish, Edward B.; Pritchard, K.I.; Oldfield, Gladys A.; Hanna, Wedad

doi:10.1016/0277-5379(87)90285-9

Cited by 41 publications

(26 citation statements)

References 17 publications

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“…Alcohol consumption was not associated with other hormone receptor subtypes postmenopausally and was generally not related to risk of any specific subtype among premenopausal patients. These results are generally consistent with those from a large case-control study conducted in New York, USA (Nasca et al, 1994), which included more than 1100 premenopausal and postmenopausal patients with breast cancer. In that study, Nasca and colleagues reported an increased risk of ER-positive, but not ER-negative, breast cancer at the highest levels of alcohol consumption.…”

Section: Discussionsupporting

confidence: 88%

“…Studies such as the one presented here may help clarify whether hormone receptor-positive and hormone receptor-negative breast tumours represent different stages in the progression of the disease or two distinct diseases with distinct aetiologies. The scientific literature includes evidence that can be interpreted to support either of these theories (Mobbs et al, 1987;Tani et al, 1988;Habel and Stanford, 1993;. Our finding that alcohol is more strongly associated with ER-positive/PR-positive risk of breast cancer among postmenopausal women supports the theory that hormone receptor status defines distinct diseases rather than different stages of the same disease.…”

Section: Discussionsupporting

confidence: 67%

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Alcohol consumption and breast cancer oestrogen and progesterone receptor status

et al. 1999

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We examined the role of alcohol on the risk of breast cancer by the joint oestrogen receptor (ER) and progesterone receptor (PR) status of the tumour using data from two case-control studies conducted in Los Angeles County, USA. Eligible premenopausal patients were 733 women aged ≤ 40 years and first diagnosed from 1 July 1983 to 1 January 1989. Eligible postmenopausal patients were 1169 women aged 55–64 years and first diagnosed from 1 March 1987 to 31 December 89. Patients were identified by the University of Southern California Cancer Surveillance Program. Neighbourhood controls were individually matched to patients by parity (premenopausal patients) and birth date (± 3 years). ER and PR status were obtained from medical records for 424 premenopausal and 760 postmenopausal patients. The analyses included 714 premenopausal and 1091 postmenopausal control subjects. Alcohol use was generally not associated with premenopausal risk of breast cancer, regardless of hormone-receptor status. Among the postmenopausal women, those who consumed, on average, ≥ 27 g of alcohol/d experienced an odds ratio (OR) of 1.76 [95% confidence interval (CI) 1.14–2.71] for ER-positive/PR-positive breast cancer relative to women who reported no alcohol consumption. Alcohol use was less clearly associated with risk of other receptor types among postmenopausal women. These data suggest that alcohol may preferentially increase risk of ER-positive/PR-positive breast cancer in postmenopausal women. © 1999 Cancer Research Campaign

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 67%

Alcohol consumption and breast cancer oestrogen and progesterone receptor status

et al. 1999

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“…Previous studies in patients with breast cancer (Taylor et al, 1982;Hamm & Allegra, 1988;Toma et al, 1986) and in experimental animals (Vignon & Rochefort, 1976;Hawkins et al, 1977b;Cho-Chung et al, 1978) have shown a decrease in receptor concentration after endocrine manipulation or, as in the present study, no consistant change (Hull et al, 1983;Mobbs et al, 1987). The conflicting results,in human breast cancer may derive from the inclusion of patients on tamoxifen (Taylor et al, 1982), which causes a marked apparent reduction in ER concentration (this study and Hull et al, 1983) or from the difficulties in comparing different tumour deposits (Taylor et al, 1982;Hamm & Allegra, 1988).…”

Section: Discussionsupporting

confidence: 39%

Does the oestrogen receptor concentration of a breast cancer change during systemic therapy?

Hawkins¹,

Tesdale²,

Anderson³

et al. 1990

Br J Cancer

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Summary The effect of systemic therapy on tumour oestrogen receptor (ER) concentration has been studied in 88 patients with large, operable, primary tumours (total 89) of the breast. In 26 patients, tumour was not available for study on one occasion (usually post-treatment). Forty-five patients were treated initially by endocrine therapy but, of these, 13 who had failed to respond went on to receive chemotherapy also. Seventeen patients with low concentrations of ER (<20 fmol mg-' protein) were treated directly by chemotherapy. Patients underwent an incisional biopsy for confirmation of diagnosis and determination of pre-treatment ER by radioligand binding assay, followed by systemic therapy for 3 months (or 6 months for both endocrine and cytotoxic therapies). Following 3 months of systemic therapy (6 months when patients received both endocrine and cytotoxic therapies), patients proceeded on to mastectomy and axillary lymphnode clearance. When residual tumour was present within the mastectomy specimen, a portion was selected for ER assay by the pathologist.In both pre-and post-treatment specimens, a section was cut from the face of the tissue portion used for receptor analysis, fixed in formol-saline and stained with haematoxylin and eosin to permit histopathological confirmation of the presence of tumour. Twenty-six patients in whom either the pre-or post-treatment specimen contained <10% tumour, as assessed by the pathologist, have been excluded from the Correspondence: R.A. Hawkins.

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“…In patients whose ER status was discordant, changes in both directions (ER-positive to ER-negative and ER-negative to ERpositive) were observed (23,27,28,30). While Hoehn et al (22) showed that ER level tended to be higher in metastatic sites, Brankovic-Magic et al (31) and Castagnetta et al (29) found that receptor values were more likely to be lower in metastatic lesions.…”

Section: Methodsmentioning

confidence: 88%

“…Drew Cancer Center will assist in the deferment of the costs associated with these incentives (see Budget). Simultaneously obtained specimens from primary and metastatic breast carcinoma have been compared for ER status (22-3 1).-In general, primary and metastatic (mostly regional lymph nodes) cancers had a high ER status concordance -85-93% (23,27,28,30).…”

Section: Methodsmentioning

confidence: 99%

Cancer Prevention and Control Research Manpower Development

Shacks¹

1997

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sourceo, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information including suggestions for reducing this burden, to Washington Headquarters Services, Directorate ABSTRACT (Maximum 200The primary aim of this project in year two was to complete the recruitment of six post-doctoral graduates. Where copyrighted material is quoted, permission has been a • ned to use such material.Where material from documents designated for limited stribution is quoted, permission has been obtained to use the t rial.Citations of commercial organizations and trade names in report do not constitute an official Department of Army endorsement or approval of the products or services of these organizations.In conducting research using animals, the investigator(s) adhered to the "Guide for the Care and Use of Laboratory Animals," prepared by the Committee on Care and use of Laboratory Animals of the Institute of Laboratory Resources, National Research Council (NIH Publication No. 86-23, Revised 1985).For the protection of human subjects, the investigator(s) adhered to policies of applicable Federal Law 45 CFR 46.In conducting research utilizing recombinant DNA technology, the investigator(s) adhered to current guidelines promulgated by the National Institutes of Health.In the conduct of research utilizing recombinant DNA, the investigator(s) adhered to the NIH Guidelines for Research Involving Recombinant DNA Molecules.In the conduct of research involving hazardous organisms, .the investigator(s) adhered to the CDC-NIH Guide for Biosafety in Microbiological and Biomedical Laboratories. IntroductionBreast cancer is a leading cause of death in American women. Women of minority groups have higher mortality rates for this disease compared to white women. To address this issue, efforts to increase minority representation in cancer research have been made by the National Institute of Medicine. Success of these activities have been limited, and the pool of minority investigators remains small. The purpose of this project is to expand the pool of minority cancer control and prevention investigators. The overall aim of this three year study is to provide training in breast cancer prevention and control research for six post-doctoral graduates. The ultimate goal is to create WU independent investigators who will obtain extramural funding upon completion of the fellowship. The hypotheses to be tested is that with "protected time" and appropriate mentors doctoral graduates in C social science and public health disciplines can achieve independent extramural funding for breast F cancer research within three years. Fellows are paired with faculty mentors from one of three Cancer Centers; Drew University of Medicine and Science in Los Ang...

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Estrogen and progesterone receptor content of primary and secondary breast carcinoma: Influence of time and treatment

Cited by 41 publications

References 17 publications

Alcohol consumption and breast cancer oestrogen and progesterone receptor status

Alcohol consumption and breast cancer oestrogen and progesterone receptor status

Does the oestrogen receptor concentration of a breast cancer change during systemic therapy?

Cancer Prevention and Control Research Manpower Development

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