Estrogen and progesterone receptors in carpal tunnel syndrome

Toesca, Amelia; Pagnotta, Alessia; Zumbo, Antonella; Sadun, R

doi:10.1016/j.cellbi.2007.08.014

Cited by 46 publications

(50 citation statements)

References 25 publications

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“…Toesca et al4 evaluated the ER and PR expression in the specimens obtained from 30 CTS cases and four controls. Both TCL and synovial tissue from CTS patients expressed ERα, but PR was observed only in TCL samples and its appearance decreased with age.…”

Section: Discussionmentioning

confidence: 99%

“…The number of ER- and PR-positive cells in non-CTS patients was significantly lower than that in CTS patients. Authors suggested that localization of the ER and PR proteins in the normal TCL is related to the theory that female sex hormones influence the physiological modulation of TCL metabolism 4. These receptors have already been supposed to have an effect on the structure of the ligaments in studies on human anterior cruciate ligament 15.…”

Section: Discussionmentioning

confidence: 99%

“…Sex hormones fluctuations predispose this ligament to the higher injury rate in female athletes by changing their composition 1617. Toesca et al4 supposed that fluctuation of estrogens and progesterone could similarly affect TCL through acting on fibroblast proliferation and collagen synthesis. Also, the effect of estrogen on synovial tissue was attributed to the immunomodulation of synovitis and synovial hyperplasia and the regulation of pro-inflammatory cytokines 4.…”

Section: Discussionmentioning

confidence: 99%

“…In a study by Kim et al3, increased expressions of estrogen receptor alpha and beta (ERα and ERβ) in the tenosynovial tissues of postmenopausal women with CTS was found 3. Although Toesca et al4 found expression of ERα in both transverse carpal ligaments (TCL) and synovial tissues and progesterone receptor (PR) in TCL samples from CTS patients, no statistically significant difference between male and female groups in the number of ER- and PR-positive cells within TCL or synovial tissue of CTS patients was seen with the exception of the 50 to 70 year age group. Despite these findings, the effect of sex hormones on CTS independent of other risk factors which may be different among men and women such as hand and wrist anthropometrics (higher wrist ratio, higher shape index, and narrower outlet in women) is not clear 567…”

Section: Introductionmentioning

confidence: 97%

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Correlation between Female Sex Hormones and Electrodiagnostic Parameters and Clinical Function in Post-menopausal Women with Idiopathic Carpal Tunnel Syndrome

et al. 2016

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ObjectivesTo investigate the role of sex-hormonal changes in idiopathic carpal tunnel syndrome (CTS) among post-menopausal women through measuring estrogen receptor (ER) expression in their transverse carpal ligament (TCL) and serum estrogen level, as well as determine the correlation between these factors and electrodiagnostic parameters and Boston score.MethodsBiopsy samples of TCL were collected from 12 postmenopausal women who had undergone surgery for severe idiopathic CTS; control specimens were collected from 10 postmenopausal women without CTS who had undergone surgery for the other hand pathologies. To determine the distributions of ER in TCL, histological and immunohistochemical examinations were performed. Serum estrogen level was also measured. Electrodiagnosis and Boston questionnaire were used for CTS severity and determination of the patients' function.ResultsER expression in TCL and serum estrogen level were not significantly different in the case group compared to the control group (P = 0.79 and P = 0.88, respectively). Also, there was no correlation between ER expression or serum estrogen level and electrodiagnostic parameters or Boston score.ConclusionsSex hormones cannot still be considered as the etiology of idiopathic CTS in postmenopausal women. The role of other factors such as wrist ratio and narrower outlet in females compared to the males should be considered along with hormonal changes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Correlation between Female Sex Hormones and Electrodiagnostic Parameters and Clinical Function in Post-menopausal Women with Idiopathic Carpal Tunnel Syndrome

et al. 2016

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“…This implicates these receptors and potentially oestrogen and progesterone in the pathogenesis of carpal tunnel syndrome. Interestingly, the number of ER positive cells in the transverse carpal ligament and synovial tissue increased with age to a peak at 55-70, decreasing thereafter [36].…”

Section: Role Of Oestrogenmentioning

confidence: 99%

Aromatase inhibitor-induced arthralgia in early breast cancer: what do we know and how can we find out more?

Din

Dodwell

Wakefield

et al. 2010

Breast Cancer Res Treat

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Aromatase inhibitors (AIs) are a standard of care for the adjuvant treatment of hormone responsive early carcinoma of the breast as demonstrated in a number of large international phase III randomised trials. Arthralgia was a somewhat unexpected side effect of this class of agents and has proven to be potentially problematic in clinical practice. Although rates of up 35% have been reported in the randomised trials, the figure has been much higher in subsequent case series. There is concern that these symptoms are significant and may affect compliance and thus the overall efficacy of treatment. It is therefore extremely important that we evaluate this syndrome with a view to gaining more information regarding its clinical features and possible aetiological mechanism. The potential aetiological mechanisms and evidence for aromatase inhibitor-induced arthralgia (AIA) are reviewed in this article. Looking forward, it is now important that prospective clinical trials are well designed to evaluate this syndrome and potential therapeutic strategies to circumvent it. Radiological imaging and biochemical analyses may help our understanding of AIA and these are discussed.

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Effect of estradiol on fibroblasts from postmenopausal idiopathic carpal tunnel syndrome patients

Yamanaka

Menuki²,

Tajima³

et al. 2018

Journal Cellular Physiology

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Fibrosis of the subsynovial connective tissue (SSCT) is a characteristic finding in patients with idiopathic carpal tunnel syndrome (CTS). Idiopathic CTS frequently occurs in postmenopausal women; therefore, female steroid hormones, especially estrogens, may be involved in its development. In this study, we evaluated the effect of the estradiol on the expression of genes and proteins related to fibrosis of SSCT fibroblasts from patients with idiopathic CTS. This study included 10 postmenopausal women (mean age 76 years). Fibroblasts derived from SSCT were treated with estradiol (10 -10 M), and the expression levels of TGF-β-responsive genes were evaluated. The relationships between the expression of untreated estrogen receptor α (ERα) and ERβ and changes in gene expression due to estradiol treatment were examined by quantitative real-time polymerase chain reaction. The effects of 10 M estradiol on collagen type I (Col1) and collagen type III (Col3) protein expression levels were also evaluated by fluorescent staining. The relationships between ERα/β and Col1/3 expression were evaluated by immunohistochemical staining. The reduction in Col1A1 mRNA expression due to estradiol treatment was positively correlated with ERα expression (r = 0.903, p < 0.01). At the protein level, expression of Col1 and Col3 were down-regulated. These results indicated that ERα-mediated signaling may be involved in the regulation of Col1A1, and its regulatory effect may be dependent on the ERα expression level. The accurate evaluation of ERα expression level in the SSCT of individual patients with idiopathic CTS might guide the effective use of new estrogen replacement therapy.

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Estrogen and progesterone receptors in carpal tunnel syndrome

Cited by 46 publications

References 25 publications

Correlation between Female Sex Hormones and Electrodiagnostic Parameters and Clinical Function in Post-menopausal Women with Idiopathic Carpal Tunnel Syndrome

Correlation between Female Sex Hormones and Electrodiagnostic Parameters and Clinical Function in Post-menopausal Women with Idiopathic Carpal Tunnel Syndrome

Aromatase inhibitor-induced arthralgia in early breast cancer: what do we know and how can we find out more?

Effect of estradiol on fibroblasts from postmenopausal idiopathic carpal tunnel syndrome patients

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