Estrogen and progesterone receptors in salivary gland adenoid cystic carcinoma

Shick, Paul C.; Riordan, G. Patrick; Foss, Robert D.

doi:10.1016/s1079-2104(05)80338-5

Cited by 52 publications

(49 citation statements)

References 35 publications

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“…Interpretation of staining due to a less than strict evaluation criteria for tumors may also account for these differences. The studies of Ozono et al [14], and Shick et al [5], as well as the current study support the fact that progesterone can be identified, although rarely, in ACC and estrogen can be ever more readily identified.…”

Section: Discussionsupporting

confidence: 87%

“…It is interesting that in the study of Shick et al [5] 50% of the tumors stained positively for PR. This finding is similar to those reported for breast carcinomas [11].…”

Section: Discussionmentioning

confidence: 91%

“…This more favorable prognosis is related to the fact that such tumors are more susceptible to hormonal manipulation therapy [11][12][13]. Some reports suggest that the presence of ER and PR in salivary glands, and salivary gland ACC may offer a similar favorable prognosis [5,14].…”

Section: Discussionmentioning

confidence: 99%

“…Shick et al [5] evaluated 12 ACCs of salivary gland origin and found that ER were not detectable. These same investigators, however, demonstrated a significantly higher PR level in ACC than in matched normal salivary gland controls.…”

Section: Discussionmentioning

confidence: 99%

“…Although no assessment parameters have proven to be absolute predictors of stable or recurrent disease, there are numerous reports in the literature delineating a possible association between salivary gland and breast cancer [3][4][5][6]. Dimery [6] analyzed estrogen receptors (ER) in normal salivary gland tissue and salivary gland carcinoma and found that eight of nine salivary gland tumors he evaluated in women had ER levels that would be considered hormone-dependent in breast carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

Barrera

Shroyer

Said

et al. 2007

Head and Neck Pathol

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Objectives The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer. Study Design ER and PR status and p53 overexpression were retrospectively evaluated utilizing immunohistochemical evaluation of 47 ACC specimens. Methods Formalin-fixed paraffin-embedded tissues from 47 ACC specimens and 47 samples of normal salivary gland tissue were evaluated histochemically for the presence of ER, PR and p53. Immunoreactivity was scored using a 0 to +3 scale in which staining was either (0) negative, (+1) spotty, (+2) weakly positive, or (+3) strongly positive. Results ER was expressed in 8 of 47 tumors while PR was expressed in 4 of 47 tumors. p53 aberrations were demonstrated in 26 of 47 tumors. Tumors showed varying degrees of immunopositivity ranging from 0 to +3. Conclusions These studies suggest that p53 aberrations may be involved in ACC tumor progression and that ER and PR may play a role in ACC development.

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Section: Discussionsupporting

confidence: 87%

“…It is interesting that in the study of Shick et al [5] 50% of the tumors stained positively for PR. This finding is similar to those reported for breast carcinomas [11].…”

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

Barrera

Shroyer

Said

et al. 2007

Head and Neck Pathol

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Sinonasal adenoid cystic carcinoma: a population‐based analysis of 694 cases

Unsal

Chung

Zhou

et al. 2016

Int Forum Allergy Rhinol

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This study represents the largest cohort of SNACC patients to date. Factors that confer a survival benefit in SNACC include M0 disease, and presentation primarily in the nasal cavity. Overall low rates of nodal metastasis may not warrant the use of elective neck dissections, unless there is clinical suspicion. Modalities of therapy that include surgery greatly improve survival. Adjuvant radiotherapy appears to slightly improve 5-year disease-free survival but does not impact long-term survival.

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Estrogen and progesterone receptors in salivary gland adenoid cystic carcinoma

Cited by 52 publications

References 35 publications

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

Sinonasal adenoid cystic carcinoma: a population‐based analysis of 694 cases

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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