Estrogen And Progesterone Receptors In Dysfunctional Uterine Bleeding

Chakravarthy, V. Kalyan

doi:10.9790/0853-0437376

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…[9] In our study we studied ER and PR expression in endometrial glands and stroma separately as well as a total expression. We found that the maximum ER and PR expression was noted in the glandular epithelium, except for PR expression in the secretory phase which was more in the stromal cells than glandular epithelial cells, a finding supported by Press et al [12] Expression of these receptors was observed to be absent from vascular smooth muscle and endothelial cells in both endometrium and myometrium in the present study; also reported by Chakraborty et al, Press et al and Snijders et al [5,12,13] It was also noted during our study that the method of endometrial sampling did not affect the demonstration of ER and PR expression, a finding corroborated by study of Garcia et al [14] Antigen retrieval for ER is considered to be difficult as stated by Shet T et al, [15] but we did not find any significant discrepancy in the staining intensity for ER and PR. Although, staining for PR was more crisp and brighter than that for ER in most of our cases, which can be easily explained by the quantitative data from steroid-binding assays indicating that the content of PR in femtomoles per milligram cytosol protein is greater than ER.…”

Section: Discussionsupporting

confidence: 91%

“…A comparable distribution of patients in different age groups has been reported by Gleeson et al, Chakraborty et al and Chakravarthy et al [3,5,6] A few studies by Dhadhania et al and Gupta et al have however reported major number of patients from the age group of 41-50 yrs age group. [7,8] The literature reflects the sociocultural differences between Indian and western communities, as marriages occur earlier in India than western world.…”

Section: Discussionsupporting

confidence: 75%

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Distribution Pattern of ER & PR Immunoexpression in Endometrial Biopsies of DUB and Infertile Patients from A Tertiary Care Centre

Thakur¹,

Kaushik²,

Garg³

et al. 2017

APALM

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Objective: To study endometrial estrogen and progesterone immunoexpression in different phases of menstrual cycle, in cases of dysfunctional uterine bleeding and infertility. A comparative analysis was also done for calculating ER & PR expression, between two methods: quick score and percentage of immunopositive cells. Methods:Endometrial biopsies from 107 clinically diagnosed DUB cases and 23 infertile patients were included in the study. Tissue sections were analyzed for different phases of menstrual cycle and immunoexpression of ER & PR receptors was calculated in glandular epithelium and stromal cells, using percentage of positively stained cells and Quick score method. Endometrial sections of hysterectomy specimens of uterovaginal prolapse cases were used as control sections. Result:In the present analysis, secretory endometrium was the commonest finding histopathologically.Mean total ER & PR expression in cases of DUB was statistically higher in the proliferative phase using both methods(p<0.05).Mean total ER expression difference in both the phases of infertility cases was not statistically significant by the observation of percentage of positively stained cells.However, quick score revealed significant difference between both receptor expression in infertile patients. Conclusion:The percentage of positive cells for ER and PR expression plays a more determinant role in studying ER and PR expression in cases of DUB and infertility as compared to quick score.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 75%

Distribution Pattern of ER & PR Immunoexpression in Endometrial Biopsies of DUB and Infertile Patients from A Tertiary Care Centre

Thakur¹,

Kaushik²,

Garg³

et al. 2017

APALM

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“…15 Chakravarthy et al have emphasized importance of evidence based stepwise approach to managing cases of AUB while discussing their findings of markedly raised endometrial ER and PR in cases of simple and complex hyperplasia, mildly raised receptors in disordered proliferation and near normal receptor status in normal proliferation and irregular shedding. 16 Significant positive correlation was found between ER and PR in all phases of menstrual cycle in infertility and abnormal uterine bleeding. This can possibly be attributed to the high estrogen levels of the proliferative phase persisting in the late secretory phase in these cases.…”

Section: Discussionmentioning

confidence: 94%

Endometrial estrogen and progesterone receptors in infertility and abnormal uterine bleeding

2020

ACHR

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Introduction: Evaluation of endometrial histology can be made more meaningful with the study of Estrogen and Progesterone receptor (ER and PR) status. Present study aimed at studying ER and PR status of normal endometrium and endometrium in infertility and abnormal uterine bleeding and elucidating its relevance and utility. Materials and Methods: This case control study was carried out on prospectively registered patients. It included 12 cases of infertility, 24 cases of abnormal uterine bleeding, 14 cases of uterine leiomyoma and 22 cases of age matched controls undergoing endometrial sampling for causes other than above mentioned conditions. The cases were subjected to thorough clinical evaluation. The study of endometrium was done with routine histology. Endometrial ER and PR expression was studied immunohistochemically. The data collected was analyzed to find out the variability of expression of endometrial ER and PR in normal and abnormal endometrium with student's t-test and correlation t-test (SPSS software version 11). Results: The ER and PR expression in normal endometrium showed cyclical variation. It was highest in the proliferative phase followed by the periovulatory phase followed by a significant decline in the late secretory phase. In cases of infertility and abnormal uterine bleeding with endometrial dysfunction; late secretory endometrium showed increased ER expression as compared to controls. Conclusion:Variations noted in endometrial ER and PR expression in infertility and abnormal uterine bleeding provided insight in its pathogenesis and helped in contemplating treatment options.

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Evaluation of Estrogen and Progesterone Receptors (Er, Pr) in Endometrial Hyperplasiaand Carcinoma- An Immunohistochemical Study

Ahmed

Gogoi

Devi

2020

ijsr

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The endometrium which lines the uterine cavity is one of the most dynamic tissues in the human body. Proliferation and differentiation of the endometrial glands and stroma are regulated by steroid hormones mainly estrogen and progesterone. Endometrial hyperplasia is a heterogeneous set of pathologic lesions that range from mild, reversible glandular proliferations to direct cancer precursors. Endometrial carcinoma is one of the most common gynecologic malignancies in industrialized and developing countries and is generally accepted to be an endocrine related neoplasm. Understanding the biochemical basis of endometrial responsiveness to hormones in such patients is fundamental to designing a successful medical therapy. The estrogen receptor (ER) and progesterone receptor (PR) are measured by biochemical and immunohistochemical methods . Immunohistochemistry (IHC) is a semiquantitative method for determination of protein expression. The technique is inexpensive and relatively quick to perform. Immunohistochemistry was done in this study to evaluate the expression of ER, PR in cases of Endometrial hyperplasia and Endometrial Carcinoma. A total of 42 cases were evaluated immunohistochemically which included 32 cases of Non atypical hyperplasia, 7 cases of Atypical hyperplasia and 3 cases of Endometrial carcinoma. The expression of ER/PR was maximal for cases of Non atypical hyperplasia, followed by atypical hyperplasia and least for endometrial carcinoma. Those can be benefited from hormonal therapy, especially atypical hyperplasia cases, whose progression can be halted by hormonal therapy.

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Estrogen And Progesterone Receptors In Dysfunctional Uterine Bleeding

Abstract: Objective:To analyze estrogen and progesterone receptors (ER, PR)

Cited by 4 publications

References 13 publications

Distribution Pattern of ER & PR Immunoexpression in Endometrial Biopsies of DUB and Infertile Patients from A Tertiary Care Centre

Distribution Pattern of ER & PR Immunoexpression in Endometrial Biopsies of DUB and Infertile Patients from A Tertiary Care Centre

Endometrial estrogen and progesterone receptors in infertility and abnormal uterine bleeding

Evaluation of Estrogen and Progesterone Receptors (Er, Pr) in Endometrial Hyperplasiaand Carcinoma- An Immunohistochemical Study

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