Estrogen and progesterone receptors in smooth muscle component of deep infiltrating endometriosis

Noël, Jean Christophe; Chapron, Charles; Bucella, Dario; Buxant, Frédéric; Peny, Marie-Odile; Fayt, Isabelle; Borghese, Bruno; Anaf, Vincent

doi:10.1016/j.fertnstert.2008.12.114

Cited by 36 publications

(32 citation statements)

References 23 publications

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“…15 Fibrotic tissue is part of the lesions, and progesterone receptors (PRs) are present not only in glands and stroma but also in smooth muscle cells and fibrosis surrounding the DIE lesions. 16 In the specific case of bowel DIE, lesions infiltrate the large bowel wall preferentially along the nerves, even at a distance from the palpated nodule, while the mucosa is rarely involved. 17 Multifocality of lesions is a major characteristic of DIE.…”

Section: Pathologymentioning

confidence: 99%

Pathogenetic Mechanisms of Deep Infiltrating Endometriosis

et al. 2015

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Endometriosis is a benign gynecologic disease, affecting women of reproductive age associated with chronic pelvic pain, dysmenorrhea, dyspareunia and infertility. Ovarian endometrioma (OMA), superficial peritoneal endometriosis (SPE), and deep infiltrating endometriosis (DIE) are, till now, recognized as major phenotypes. The discussion is to know whether they share the same pathogenetic mechanisms. Till today, DIE is recognized as the most severe clinical form of endometriosis and has a complex clinical management. The DIE lesions have been considered in the present article, without distinguishing between the anterior (bladder) or the posterior (vagina, uterosacral ligaments, rectum, and ureter) compartment. The present knowledge indicates that hormonal function (estrogen and progesterone receptors) and immunological factors, such as peritoneal macrophages, natural killer cells, and lymphocytes, are critically altered in DIE. The aggressive behavior of DIE may be explained by the highly decreased apoptosis (nuclear factor kappa-light-chain-enhancer of activated B cells [NF-kB], B-cell lymphoma 2 [Blc-2], and anti-Mullerian hormone) and by the increased proliferation activity related to oxidative stress (NF-kB, reactive oxygen species, extracellular regulated kinase (ERK), advanced oxidation protein product). Invasive mechanisms are more expressed (matrix metalloproteinases and activins) in DIE in comparison to the OMA and SPE. Correlated with the increased invasiveness are the data on very high expression of neuroangiogenesis (nerve growth factor, vascular endothelial growth factor, and intercellular adhesion molecule) genes in DIE. Therefore, at the present time, several of the DIE pathogenetic features result specific in comparison to other endometriosis phenotypes, pleading for the existence of a specific entity. These evidence of specific pathogenetic features of DIE may explain the more severe symptomatology related to this form of endometriosis and suggest possible future target medical treatments.

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Section: Pathologymentioning

confidence: 99%

Pathogenetic Mechanisms of Deep Infiltrating Endometriosis

et al. 2015

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“…The final score was the product of intensity and frequency scores. Final expression scores were categorized as follows: negative (0-1), weak (2-4), moderate (5)(6)(7)(8), and strong (9-12).…”

Section: Scoringmentioning

confidence: 99%

“…4,5 Despite its clinical importance, there are few studies that focused on DE lesions exclusively when investigating the pathogenesis of the disease. 6,7 Most research has focused on peritoneal and ovarian endometriosis, and the conclusions drawn from those studies were generalized to explain the pathogenesis of the disease as a whole. [8][9][10][11] To further investigate DE specifically, rectosigmoid endometriosis (RE) is an acceptable model because it has many characteristics of DE lesions, such as being composed of scanty glands and stroma among smooth muscle exhibiting extensive hyperplasia and metaplasia.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study

et al. 2015

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“…Endometriosis is characterized by endometriotic tissue consisting of hormone-dependent glandular formations, stromal cells and smooth muscle in sites located outside of the uterine cavity [1][2][3][4][5][6]. The estimated prevalence of endometriosis is high and makes it to one of the most common pathologies in women of reproductive age [1,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Magnet Resonance Imaging in Preoperative Endometriosis: Incidence of High-Signal-Intensity Spots on Fat-Suppressed T1-Weighted and T2-Weighted Images

Krüger¹

2017

OGIJ

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Objectives: To investigate the incidence of high-signal-intensity lesions at preoperative T1 and T2-weighted magnet resonance imaging (MRI) in patients with pelvic endometriosis.Study Design: Between 2009 and 2012, 252 women with clinical and sonographic suspicion of endometriosis underwent pelvic MRI using T2 and unenhanced T1 sequences with and without fat saturation. Two radiologists interpreted the following regions retrospectively by consensus according to a standardized protocol: uterus, vagina, pouch of Douglas, rectum, uterosacral ligament (USL). High-signal-intensity lesions in the fat-suppressed T1-weighted images were defined as hemorrhagic foci. Their incidence and that of high-signal-intensity spots in T2-weighted images were documented in histopathological verified endometriosis. Results:In patients with rectal endometriosis (128/252 patients), high-signalintensity spots were detected on 10.2% of T1-weighted fat-suppressed images and on 16.9% of T2-weighted images. In uterus adenomyosis (236/252 patients) high-signal-intensity spots on T1 and T2 weighted images occurred in 43.2% and 24.2%, respectively (vagina (115/252, 31.3% and 41.9%; USL 119/252, 7.6% and 13.8%, pouch of Douglas 169/252, 31.4% and 28.1%, other localizations 7/252, 71.4% and 57.1%) Conclusion:The incidence of high-signal-intensity spots on T1 and T2-weighted images depends on the localization of endometriosis. T1 und T2 high-signalintensity spots are less relevant in diagnosing endometriosis of the rectum and uterosacral ligament.

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Estrogen and progesterone receptors in smooth muscle component of deep infiltrating endometriosis

Cited by 36 publications

References 23 publications

Pathogenetic Mechanisms of Deep Infiltrating Endometriosis

Pathogenetic Mechanisms of Deep Infiltrating Endometriosis

The Relationship Among HOXA10, Estrogen Receptor α, Progesterone Receptor, and Progesterone Receptor B Proteins in Rectosigmoid Endometriosis: A Tissue Microarray Study

Magnet Resonance Imaging in Preoperative Endometriosis: Incidence of High-Signal-Intensity Spots on Fat-Suppressed T1-Weighted and T2-Weighted Images

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