Estrogen‐eluting stent implantation inhibits neointimal formation and extracellular signal‐regulated kinase activation

Han, Yaling; Liang, Ming; Kang, Jian; Qi, Yanmei; Xu, Kai; Cao, Yan

doi:10.1002/ccd.21156

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…Local delivery of estradiol decreases coronary angioplasty-induced neointimal hyperplasia in pigs (59, 60). These studies led to the development of estrogen-eluting stents, which reduce neointimal proliferation and induce reendothelialization in rabbit aorta (61) and porcine coronary artery (62). This protective effect of estrogen on vascular injury is evident in both ERα (63) and ERβ (63) knockout mice, indicating that another receptor may mediate this hormone's effects in the vasculature.…”

Section: Atherosclerosis and Vascular Remodelingmentioning

confidence: 99%

GPER–novel membrane oestrogen receptor

et al. 2016

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The recent discovery of the G protein-coupled estrogen receptor (GPER) presents new challenges and opportunities for understanding the physiology, pathophysiology, and pharmacology of many diseases. This review will focus on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodeling, heart failure, reproduction, metabolic disorders, cancer, environmental health, and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target.

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Section: Atherosclerosis and Vascular Remodelingmentioning

confidence: 99%

GPER–novel membrane oestrogen receptor

et al. 2016

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“…It was the use of MPC polymer (PMPC) coatings on coronary stents to deliver antirestenosis therapies in the bloodstream that demonstrated the potential of PMPC materials in the field of drug delivery − . In recent years, there have been reports of the use of water-soluble copolymers of MPC for solubilization of drugs such as paclitaxel and amphotericin B − .…”

Section: Introductionmentioning

confidence: 99%

Poly(2-methacryloyloxyethyl phosphorylcholine) for Protein Conjugation

et al. 2008

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The water-soluble, biocompatible polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) was evaluated for protein conjugation. PMPC is a zwitterionic polymer that is able to form a more compact conformation in aqueous solution than poly(ethylene glycol) (PEG). While a terminally functionalized N-hydroxysuccinimide derivative of PMPC was not efficient for conjugation to an amine moiety on interferon-alpha2a (IFN), we found that a bis-thiol specific derivative of PMPC could be conjugated after reduction of the disulfide bonds in IFN. Utilizing PMPC that displayed a similar hydrodynamic volume to 20 kDa PEG, we evaluated the in vitro antiviral and antiproliferative activity and pharmacokinetics of a PMPC-IFN conjugate. As a hygroscopic zwitterionic polymer, PMPC is able to form a compact conformation in aqueous solution, which was found to be more compact than PEG. This suggests that PMPC protein conjugates may display different plasma elimination characteristics than PEG protein conjugates. PMPC-IFN displayed marked resistance to antibody binding in Western blot analysis with a polyclonal anti-IFN antibody while displaying comparable in vitro antiviral and antiproliferative activity to PEG-IFN. During an in vivo pharmacokinetic study, the absorption t(1/2) for PMPC-IFN was considerably extended compared to the native IFN and 20 kDa PEG analogue. This is also consistent with the SDS-PAGE result where an apparent reduction in mobility through a hydrated medium was observed. The elimination t(1/2) was also vastly extended over the native IFN and twice the value of 20 kDa PEG-IFN. This suggests that tissue migration of PMPC-IFN occurs more slowly than the 20 kDa PEG-IFN despite their similarity in hydrodynamic volume, leading to an an improved depot effect, which could explain the longer elimination t(1/2). In this study, we demonstrate a potential use of PMPCylation as a novel tool for enhancing the pharmacokinetic profile of therapeutic proteins in ways that complement PEGylation.

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“…Other effects of estrogen in blood vessels include endothelial proliferation via activation of mitogen-activated protein kinase (MAPK); in contrast, MAPK in vascular smooth muscle (VSM) is suppressed [161,162]. The growth promoting effects of angiotensin II (AngII) on VSM is antagonized by estrogen, and it also suppresses VSM migration [163]. In rodent models, estrogen has been shown to enhance expression of angiogenic molecules like angiopoietin-1 and stimulate angiogenesis [164].…”

Section: Estrogen Endothelium and Vascular Smooth Musclementioning

confidence: 98%

Stroke in Women

Saini

Shuaib²

2008

PRC

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Stroke remains one of the leading causes of morbidity and mortality worldwide. Sexual differences in stroke have been recognized, though the mechanisms remain unclear. Women have a unique risk factor profile, especially so in the reproductively active age group. Exposure to oral contraceptives, hormone replacement therapy and a higher incidence of migraine and vasculitic disorders in women suggest that stroke would be common in women. Yet, the incidence of stroke remains higher in men across all ages, indicating a protective role of sex hormones. The differences in incidence and prevalence of stroke decreases as women age, confirming that hormones play a pivotal role in terms of normal physiology, disease and recovery. Recent evidence also points to sex based differences in response to therapy, in terms of acute management and prevention. Gender based differences in accessibility and provision of health care facilities add to the observed differences in terms of stroke outcome, though here women seem to fare worse than men. This review summarizes the observed sex differences in stroke, possible hormonal mechanisms that may explain the same and outlines recent patents and scope for future research in this field.

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Estrogen‐eluting stent implantation inhibits neointimal formation and extracellular signal‐regulated kinase activation

Abstract: Current study suggests that estrogen-eluting stents reduce neointimal formation and hence prevent restenosis after angioplasty possibly by inhibiting ERK activation in smooth muscle cells and promoting reendothelialization.

Cited by 8 publications

References 20 publications

GPER–novel membrane oestrogen receptor

GPER–novel membrane oestrogen receptor

Poly(2-methacryloyloxyethyl phosphorylcholine) for Protein Conjugation

Stroke in Women

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