Estrogen Enhances Endometrial Cancer Cells Proliferation by Upregulation of Prohibitin

Yang, Bin; Chen, Ruiying; Liang, Xiaoyan; Shi, Jiayan; Wu, Xiaomei; Zhang, Zhenbo; Xiong, Chen

doi:10.7150/jca.28218

Cited by 18 publications

(19 citation statements)

References 34 publications

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“…Depletion of adapter protein of E3 ubiquitin ligase promotes endometrial cancer cell growth 22 . Inhibition of ubiquitination leads to stabilization, increases prohibition, and facilitates endometrial cancer cell proliferation 23 . In addition, deubiquitination is implicated in sensitization of endometrial cancer cells to estrogen 24 .…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer

et al. 2020

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Genetic instability, raised from dysregulation of DNA repair, is involved in tumor development. OTUB2 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-binding protein 2), which is responsible for DNA double-strand break (DSB), is implicated in carcinogenesis of various tumors. The effect of OTUB2 on endometrial cancer progression was then investigated. First, OTUB2 was found to be upregulated in endometrial cancer tissues and cell lines, and was closely associated with overall survival of endometrial cancer patients. Cell Counting Kit-8 and flow cytometry assay results revealed that overexpression of OTUB2 enhanced cell viability of endometrial cancer cells, while knockdown of OTUB2 inhibited cell viability. Moreover, as demonstrated by promoting cell viability and suppression of cell apoptosis, cisplatin-induced cell damage was reversed by OTUB2. Mechanistically, OTUB2 could activate Yes-associated protein/transcriptional co-activator with PDZ-binding motif (TAZ) to promote homologous recombination repair via depletion of γH2AX (phosphorylation of histone H2AX) and accumulation of Rad51. In vivo xenograft model also showed that silence of OTUB2 suppressed the growth of endometrial cancer and increased tumor sensitivity to antitumor drugs. In conclusion, OTUB2 promoted homologous recombination repair in endometrial cancer via YAP/TAZ-mediated Rad51 expression, providing a potential therapeutic target for endometrial cancer.

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Section: Discussionmentioning

confidence: 99%

RETRACTED: OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer

et al. 2020

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“…PHB is an independent prognostic factor for PDAC [18]. PHB overexpression is detected in endometrial cancer tissues and is linked to poor prognosis [19]. PHB protein is highly expressed in Wilms tumor specimens and is correlated with the tumor stage.…”

Section: Discussionmentioning

confidence: 99%

Aberrant Expression of Prohibitin Is Related to Prognosis of Nasal Extranodal Natural Killer/T Cell Lymphoma, Nasal Type

Guo

Chen

et al. 2020

Oncol Res Treat

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Introduction: Nasal extranodal natural killer (NK)/T cell lymphoma, nasal type (ENKTCL) is a high-grade Epstein-Barr virus (EBV)-associated malignancy with poor outcomes. There are few biomarkers for the accurate diagnosis and prognostic prediction of the disease. The aim of this study was to investigate the clinicopathological significance of prohibitin (PHB) expression in nasal ENKTCL. Methods: The expression level of PHB was detected via immunohistochemical staining in 49 nasal ENKTCL tissues and age-and sex-matched controls of 30 nasal mucosa-reactive lymphoid hyperplasia (NRLH) tissues. The correlations between the PHB expression and clinicopathological features of patients with nasal ENKTCL were evaluated. Results: The results indicated a significantly decreased expression of PHB in nasal ENKTCL tissues compared with in NRLH tissues. Low-level PHB expression was significantly associated with younger age and fever (p = 0.008 and 0.018, respectively). The Kaplan-Meier analysis showed that the cytoplasm expression level of PHB in nasal ENKTCL was inversely related to overall survival (p = 0.046). Conclusions: PHB may be a potential diagnostic marker and prognostic predictor of nasal ENKTCL.

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“…As far as we know, aberrant estrogen metabolism was also greatly involved in endometrial cancer growth and metastasis. [68][69][70] Zhang et al 25 first explored the association between FTO and estrogen in endometrial cancer, they found that β-estradiol (E2) up-regulated FTO expression, thus enhancing endometrial cancer cell proliferation, migration and invasion via activating phosphatidylinositol-3-kinase (PI3K)/protein kinase b (AKT) and mitogen-activated protein kinase (MAPK) signal pathways. PI3Ks were key regulators of intracellular signaling in response to the extracellular stimulators.…”

Section: Fto In Endometrial Cancermentioning

confidence: 99%

<p>The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers</p>

Wang¹,

Chen²,

Qiang³

2020

OTT

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N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene ( FTO ), previously recognized to be related with obesity and diabetes, was gradually discovered to be dysregulated in multiple cancers and plays an oncogenic or tumor-suppressive role. However, the specific expression and pro- or anti-cancer role of FTO in various cancers remained controversial. In this review, through summarizing the available literature, we found that FTO single nucleotide polymorphisms (SNPs) were closely related with cancer risk. Additionally, the dysregulation of FTO was implicated in multiple biological processes, such as cancer cell apoptosis, proliferation, migration, invasion, metastasis, cell-cycle, differentiation, stem cell self-renewal and so on. These modulations mostly relied on the communications between FTO and specific signaling pathways, including PI3K/AKT , MAPK and mTOR signaling pathways. Furthermore, FTO had great potential for clinical application by serving as a prognostic biomarker.

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Estrogen Enhances Endometrial Cancer Cells Proliferation by Upregulation of Prohibitin

Cited by 18 publications

References 34 publications

RETRACTED: OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer

RETRACTED: OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer

Aberrant Expression of Prohibitin Is Related to Prognosis of Nasal Extranodal Natural Killer/T Cell Lymphoma, Nasal Type

<p>The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers</p>

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