2007
DOI: 10.1038/sj.onc.1210592
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Estrogen-induced and TAFII30-mediated gene repression by direct recruitment of the estrogen receptor and co-repressors to the core promoter and its reversal by tamoxifen

Abstract: Estradiol (E 2 ) acts through the estrogen receptor (ER) to downregulate many genes, and tamoxifen (Tam) largely reverses this repression but the underlying mechanisms are unclear. Repression of the folate receptor (FR)-a P4 core promoter by ER is enhanced by E 2 and reversed by Tam. This effect was unaffected by inhibition of new protein synthesis and required the E/F and the DNA-binding domains of ER without direct binding of ER to DNA. The repression by E 2 /ER was not specific for either Sp1 or TATA elemen… Show more

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Cited by 23 publications
(20 citation statements)
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“…This was a surprising finding given the importance of distal sites in models of E2 activation (9,44,61). However, review of the limited reports on E2 repression of genes shows that the elements necessary for repression reside at or near the transcription start site (2,22,25,43,59,60,64,71). We noted greater variability in ER␣ occupancy at ESR1 compared to activated pS2.…”
Section: Discussionmentioning
confidence: 75%
See 1 more Smart Citation
“…This was a surprising finding given the importance of distal sites in models of E2 activation (9,44,61). However, review of the limited reports on E2 repression of genes shows that the elements necessary for repression reside at or near the transcription start site (2,22,25,43,59,60,64,71). We noted greater variability in ER␣ occupancy at ESR1 compared to activated pS2.…”
Section: Discussionmentioning
confidence: 75%
“…Microarray analyses of E2-treated breast cancer cell lines show that the number of repressed genes is greater than or near the number of activated genes (10,19,29,32). Yet, there are limited reports investigating E2-induced repression, and no generalized mechanism has emerged (6,13,22,25,43,47,59,60,71,74). Antagonistinduced repression by selective ER modulators involves conformational changes that prevent coactivator binding to ER␣ (55).…”
mentioning
confidence: 99%
“…2C), suggesting that the suppressive effect of E2 on FPN was through a transcriptional mechanism, rather than a translational mechanism. Additionally, tamoxifen, which acts as an antagonist of E2 action by binding to ER, [35] notably reversed this inhibitory effect at the concentration of 1 μM (Fig. 2D), further indicating that FPN could be modulated through E2 signaling pathway.…”
Section: E2 Repressed the Expression Of Fpn In Pma-differentiated Thpmentioning
confidence: 78%
“…In our laboratory and elsewhere, a direct role of ER␣ and of corepressor/histone deacetylase (HDAC)-containing complexes has been demonstrated in the regulation of some estrogen (E2)-repressed target genes (32,40). Carroll et al (5) have highlighted a role for the coregulator NRIP1/RIP140 in the regulation of late E2-repressed target genes, while other mechanisms proposed to be involved in ER␣-mediated transcriptional repression include physiological squelching of coactivator proteins and involvement of components of the basal transcriptional machinery (7,19).…”
mentioning
confidence: 99%