Estrogen-like effects of wine extracts on nitric oxide synthesis in human endothelial cells

Simoncini, Tommaso; Lenzi, E; Zöchling, Alfred; Gopal, Santhosh; Goglia, Lorenzo; Russo, Eleonora; Polak, Kinga; Casarosa, Elena; Jungbauer, Alois; Genazzani, Alessandro D.; Genazzani, Andrea R.

doi:10.1016/j.maturitas.2011.07.004

Cited by 19 publications

(10 citation statements)

References 20 publications

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“…An increase in serum cGMP in hypercholesterolemic individuals has also been noted after supplementation with purified anthocyanins (Hugel et al., ). Finally, many additional mechanisms have been reported for berry flavonoids in animal and in vitro studies and include: increase serum cGMP, up‐regulation of superoxide dismutase (SOD), glutathione reductase (GSR), thioredoxin reductase 1, and paraoxonase, decreased production of endothelin‐1, and inhibition of angiotensin‐converting enzyme (Chalopin et al., ; Edirisinghe, Banaszewski, Cappozzo, McCarthy, & Burton‐Freeman, ; Hidalgo et al., ; Lazze et al., ; Paixão, Dinis, & Almeida, ; Persson, Persson, & Andersson, ; Rodriguez‐Mateos et al., ; Simoncini et al., ; Xu, Ikeda, & Yamori, , b). The diversity of such activities is paralleled in a microarray analysis of aortic tissue from apo E‐deficient mice fed bilberry, indicating modulation of over 1,200 genes involved in cellular and molecular pathways relating to cholesterol metabolism, inflammatory process, oxidative stress, and angiogenesis (Mauray et al.…”

Section: Bioactivitymentioning

confidence: 99%

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Williamson

Kay

Crozier

2018

Comp Rev Food Sci Food Safe

445

288

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Flavonoids are plant-derived dietary components with a substantial impact on human health. Research has expanded massively since it began in the 1930s, and the complex pathways involved in bioavailability of flavonoids in the human body are now well understood. In recent years, it has been appreciated that the gut microbiome plays a major role in flavonoid action, but much progress still needs to be made in this area. Since the first publications on the health effects of flavonoids, their action is understood to protect against various stresses, but the mechanism of action has evolved from the now debunked simple direct antioxidant hypothesis into an understanding of the complex effects on molecular targets and enzymes in specific cell types. This review traces the development of the field over the past 8 decades, and indicates the current state of the art, and how it was reached. Future recommendations based on this historical analysis are (a) to focus on key areas of flavonoid action, (b) to perform human intervention studies focusing on bioavailability and protective effects, and (c) to carry out cellular in vitro experiments using appropriate cells together with the chemical form of the flavonoid found at the site of action; this could be the native form of compounds found in the food for studies on digestion and the intestine, the conjugated metabolites found in the blood after absorption in the small intestine for studies on cells, or the chemical forms found in the blood and tissues after catabolism by the gut microbiota.

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Section: Bioactivitymentioning

confidence: 99%

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Williamson

Kay

Crozier

2018

Comp Rev Food Sci Food Safe

445

288

View full text Add to dashboard Cite

show abstract

“…Recently, several studies have considered ACN benefits after degradation by colonic microbiota. These metabolites may contribute to the bioavailability of ACNs and may be responsible for antioxidant and protective effects as nitric oxide production increases ; they inhibit angiotensin‐converting enzymes to improve blood pressure ; minimize weight gain and improve glucose metabolism ; improve the plasma lipid profile and inflammation ; positively modulate the intestinal bacterial population by enhancing the growth of Bifidobacterium spp., Lactobacillus spp., and Enterococcus spp. ; and reduce Clostridium histolyticum , a potentially harmful bacterium .…”

Section: Anthocyanins and Gut Microbiota Modulationmentioning

confidence: 99%

Contribution of anthocyanin‐rich foods in obesity control through gut microbiota interactions

2017

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Obesity is characterized by low-grade inflammation and a number of metabolic disorders. Distal gut microbes' content (microbiota) is not yet fully understood but evidence shows that it is influenced by internal and external factors that modulate its composition and function. The evidence that gut microbiota composition can differ between healthy and obese individuals, as well as for those who maintain specific dietary habits, has led to the study of this environmental factor as a key link between the pathophysiology of obesity and gut microbiota. Data obtained about the role of anthocyanins (ACNs) in microbiota may lead to different strategies to manipulate bacterial populations and promote health. Anthocyanins have been identified as modulators of gut microbiota that contribute to obesity control and these bioactive compounds should be considered to have a prebiotic action. This review addresses the relevance of knowledge about the influence of anthocyanins-rich food consumption on microbiota, and their health-promoting potential in the pathophysiology of obesity. © 2017 BioFactors, 43(4):507-516, 2017.

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“…These concerns have heightened public interest in alternative medicines as a substitute for pharmacological hormone replacement therapy [8-10]. Studies report on plant-derived estrogenic activity from diverse sources [11-13]. Phytoestrogens are a heterogeneous group of non-steroidal plant-derived compounds that share structural similarities with naturally occurring estrogenic substances, such as 17-β-estradiol (E2) [14,15].…”

Section: Introductionmentioning

confidence: 99%

Estrogen Receptor Is Activated by Korean Red Ginseng In Vitro but Not In Vivo

Shim¹,

Lee²

2012

Journal of Ginseng Research

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Ginseng has been used as a traditional medicine for treatment of many diseases and for general health maintenance in people of all ages. Ginseng is also used to ameliorate menopausal systems. We investigated the estrogenic activity of Korean red ginseng (KRG) in a transient transfection system, using estrogen receptor (ER) and estrogen-responsive luciferase plasmids in MCF-7 cells. The extract activated both ERα and ERβ. KRG modulated the mRNA levels of estrogen-responsive genes such as pS2 and ESR1 and decreased the protein level of ERα. In order to examine in vivo estrogenic activity of KRG, sixteen female Sprague-Dawley rats separated into four groups were studied for nine weeks: non-ovariectomized (OVX) rats treated with olive oil, OVX rats treated with olive oil, OVX rats treated with 17-β-estradiol (E2) in olive oil, and OVX rats treated with KRG extract in olive oil. The experiments were repeated for three times and the data of twelve rats were combined. Body weight of OVX rats was greater than that of sham-operated control rats and was decreased by E2 treatment. Uterine weight increased after E2 treatment compared to OVX rats. However, no difference in body or uterine weight was observed with KRG intake. KRG induced reductions in total cholesterol, low density lipoprotein cholesterol/total cholesterol, high density lipoprotein cholesterol/total cholesterol, and low density lipoprotein cholesterol/high density lipoprotein cholesterol, but not to the same degree as did E2 intake. These results show that KRG does contain estrogenic activity as manifested by in vitro study but the activity is not strong enough to elicit physiological responses.

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Estrogen-like effects of wine extracts on nitric oxide synthesis in human endothelial cells

Cited by 19 publications

References 20 publications

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective

Contribution of anthocyanin‐rich foods in obesity control through gut microbiota interactions

Estrogen Receptor Is Activated by Korean Red Ginseng In Vitro but Not In Vivo

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