Estrogen, menopause and joints

Fenton, Anna; Panay, Nick

doi:10.3109/13697137.2016.1151151

Cited by 19 publications

(10 citation statements)

References 13 publications

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“…Lower BMI has also been described as a risk factor for early menopause in observational studies (Morris et al, 2012). Investigators found that higher oestrone production in the adipose tissue of obese women could postpone menopause (Fenton and Panay, 2016). As an endocrine and paracrine organ, adipose tissue is expected to produce substantial adipokines like leptin (Fasshauer and Bluher, 2015), contributing to the regulation of the hypothalamuspituitary-ovary axis and communicating information about the body's energy reserve to the brain (Zhang et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

An Appraisal of the Role of Previously Reported Risk Factors in the Age at Menopause Using Mendelian Randomization

et al. 2020

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Objective: Menopause at a young age is associated with many health problems in women, including osteoporosis, depressive symptoms, coronary disease, and stroke. Many traditional observational studies have reported some potential risk factors for early menopause but have drawn different conclusions. This inconsistency can be attributed mainly to unmodified confounding factors. Identifying the factors causally associated with age at menopause is important for early intervention in women with abnormal menopause timing, and for improving the quality of life for postmenopausal women. This study aims to appraise whether the previously reported risk factors are causally associated with early age at natural menopause (ANM) susceptibility. Methods: We used Mendelian randomization, a statistical method wherein genetic variants are used to determine whether an observational association between a risk factor and an outcome is consistent with a causal effect. Results: Women with earlier age at menarche (β = 0.34, se = 0.16, p = 0.035), lower education level (β = 1.19, se = 0.41, p = 0.004) and higher body mass index (β = −0.05, se = 0.02, p = 0.027) had greater risk for early ANM. The causal link between early age at menarche and early ANM was replicated using ReproGen consortium data (β = 0.23, se = 0.07, p = 0.001). However, a current smoking habit, one of previously reported risk factors, was less likely to be correlated causally with early ANM, suggesting that previous observational studies may not have sufficiently adjusted for confounders. Conclusion: Our results help to identify the risk factors of ANM via a genetics approach and future research into the biological mechanism could further help with targeted prevention for early menopause.

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Section: Discussionmentioning

confidence: 99%

An Appraisal of the Role of Previously Reported Risk Factors in the Age at Menopause Using Mendelian Randomization

et al. 2020

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“…These end-stage disease women with breast cancer are generally seriously estrogen deficient for very long periods, either by spontaneous or by induced menopause or more often due to long-term anti-estrogen treatments. This may cause not only annoying hot flushes and sweating interfering with sleep, but also osteoarthralgia (Fenton and Panay 2016). Furthermore, depression, and other mood changes, as well as more objective signs of estrogen deficiency, such as bone loss, fractures and cognition problems, occur.…”

Section: Discussionmentioning

confidence: 99%

Tumor suppression, dose-limiting toxicity and wellbeing with the fetal estrogen estetrol in patients with advanced breast cancer

Schmidt

Lenhard

Hoenig

et al. 2020

J Cancer Res Clin Oncol

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Purpose The aim of this study (the ABCE4 study) was to assess dose-limiting toxicity (DLT), safety, tolerability and preliminary efficacy of high doses of the fetal estrogen estetrol (E4) in postmenopausal patients with heavily pretreated, locally advanced and/or metastatic ER+/HER2−breast cancer, resistant to anti-estrogens. Methods This was a multicenter, open-label, phase IB/IIA, dose-escalation study with a 3 + 3 cohort design, whereby successive cohorts of three patients received 20 mg, 40 mg or 60 mg E4 per day for 12 weeks by oral administration. DLTs, safety and wellbeing were evaluated after 4, 8 and 12 weeks of treatment. Anti-tumor effects were investigated by computer tomography scanning and evaluated according to RECIST criteria before and after 12 weeks of treatment. Wellbeing was judged weekly by the investigator and by quality-of-life questionnaires by the patients. In view of the small number of patients, no statistical testing was performed. Results All 12 patients enrolled had progressive, heavily pre-treated advanced breast cancer. No treatment-related serious adverse events or DLTs occurred during the first 4 weeks of E4 treatment allowing the investigation of all three doses. Five of nine patients completing 12 weeks of E4 treatment showed objective anti-tumor effects and six of nine patients reported improved wellbeing. Conclusion High doses of estetrol seem to be safe and are well tolerated during 12 weeks of treatment without dose-limiting toxicity and with anti-tumor effects in five of nine heavily treated patients with progressive, anti-estrogen resistant, advanced breast cancer.

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“…However, other studies illustrate that menopause is associated with cartilage degeneration of knee joint. After menopause, cartilage showed progressive severe degeneration that occurred in the first 25 years of menopause, suggesting estrogen deficiency might be a risk factor of cartilage degeneration of the knee joint [22][23][24]. Even though, hot flush/sweating, heart discomfort and sleep problems were also reported at mild and moderate levels with comparatively of less number of cases, while joint and muscular discomfort dominates.…”

Section: Discussionmentioning

confidence: 99%

Association Between Physical Activities and Menopausal Symptoms Among Menopausal Women

Alrashidi¹,

Shamandy²,

Al-Turki³

2019

AJNS

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Menopause play a vital role in woman's life. Recent study emphasized that physical activities are becoming one of the most important alternative treatments to deal with menopausal symptoms. This study aims to determine the association between level of physical activities and menopausal symptoms among women. A cross sectional study design was used in carrying out this study. The study conducted at King Fahad Hospital of University (KFHU) in its Outpatient Department (OPD) from March to May 2018 with a total sample of 208 women who visiting the previous mentioned setting according to the inclusion criteria. Three tools were used to collect data: A structured questionnaire sheet was developed and used by the researcher after reviewing the related literatures to collect socio-demographic data. A standardized tool (Menopausal Rating Scale-MRS) was used to know the prevalence and severity of menopausal symptoms and a standardized tool (Leisure-Time Exercise Questionnaire-LTEQ) was used to assess physical activities intensity. The results of the present study revealed that more than half of the participants had moderate level of the severity of menopausal symptoms (53.4%). This study also shows that the (82%) of them were more likely to do only mild exercise and only two symptoms namely hot flush/sweating from somatic symptoms and depressive mood under psychological symptoms demonstrated statistical significance with p values 0.002 & 0.029 respectively. Also, it is observed in this study that Body Mass Index (BMI) and the menopausal symptoms which comes under the somatic symptoms provides a high statistical significance with p value of 0.001. The study signifies that more than half of menopausal women (53.4%) were in the normal menopausal age and most women with a normal BMI (69.2%). While signifies the prevalence of joint and muscular discomfort was the highest among the four somatic menopausal symptoms with 95.2% of participants, followed by bladder problems was the highest among urogenital subscales with (88.5%). However, the physical and mental exhaustions was the highest among psychological subscales with 84.1% of the participants.

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Estrogen, menopause and joints

Cited by 19 publications

References 13 publications

An Appraisal of the Role of Previously Reported Risk Factors in the Age at Menopause Using Mendelian Randomization

An Appraisal of the Role of Previously Reported Risk Factors in the Age at Menopause Using Mendelian Randomization

Tumor suppression, dose-limiting toxicity and wellbeing with the fetal estrogen estetrol in patients with advanced breast cancer

Association Between Physical Activities and Menopausal Symptoms Among Menopausal Women

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