2001
DOI: 10.1016/s0303-7207(00)00418-4
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Estrogen metabolism and malignancy: analysis of the expression and function of 17β-hydroxysteroid dehydrogenases in colonic cancer

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Cited by 38 publications
(26 citation statements)
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“…The loss of 17HSD type 2 expression could result in a significant increase of the more biologically active E2. It has been shown in colon cancer that loss of type 2 is an early event in cancer development, and the authors suggested that type 2 protects the colonic mucosa from E2 (English et al, 2001). In a more recent study, Oduwole et al suggest that low expression of 17HSD type 2 in colon cancer is an independent marker of favourable prognosis in females.…”
Section: Discussionmentioning
confidence: 99%
“…The loss of 17HSD type 2 expression could result in a significant increase of the more biologically active E2. It has been shown in colon cancer that loss of type 2 is an early event in cancer development, and the authors suggested that type 2 protects the colonic mucosa from E2 (English et al, 2001). In a more recent study, Oduwole et al suggest that low expression of 17HSD type 2 in colon cancer is an independent marker of favourable prognosis in females.…”
Section: Discussionmentioning
confidence: 99%
“…Estrogens play a crucial role in regulating the growth, differentiation, and function of many reproductive tissues, and the principal physiologic estrogen 17h-estradiol is considered to be a major risk factor in the development of breast cancer and has also been implicated in the etiology of colorectal and prostate cancer (20)(21)(22). A major role of the MAPK ERK pathway is to modulate gene transcription involved in cell proliferation and migration, and ERK activation has been reported in human mammary and prostate cancer tissues (23,24).…”
Section: Introductionmentioning
confidence: 99%
“…In addition to their effects on sexual development and reproductive functions, the cardiovascular system, the central nervous systems, and bone, both exogenous and endogenous estrogens exert significant effects on gastrointestinal physiology. 3 Estrogens have also been implicated in the development and progression of CC 3 and sex-specific differences have been suggested to be involved in the process. 4 The lifetime risk seems to be significantly lower and the survival rates better 5 in females than in males.…”
mentioning
confidence: 99%
“…Epidemiologic studies have demonstrated that colorectal cancer incidence and mortality rates are lower in women than men. 3 Many studies indicate that estrogen replacement therapy (ERT) exerts a protective role against CC in postmenopausal women. 4 The steroid hormone 17b-estradiol (E2) is a critical regulator of growth, differentiation, and function in a wide range of target tissues.…”
mentioning
confidence: 99%