Estrogen receptor 1 gene (<i>ESR1</i>) variants in panic disorder

Sand, Philipp; Schlurmann, K.; Luckhaus, Christian; Götz, Monika; Stöber, Gerald; Lesch, Klaus‐Peter; Riederer, Peter; Franke, Petra; Maier, Wolfgang; Nöthen, Markus M.; Propping, Peter; Fritze, Jürgen; Deckert, J.

doi:10.1002/ajmg.10359

Cited by 10 publications

(2 citation statements)

References 14 publications

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“…A role for progesterone in panic is further suggested by the significantly greater occurrence of the progesterone receptor gene G331A polymorphism in women but not men with panic compared with control participants (Ho et al, 2004). In contrast, no association was found for the estrogen receptor 1 gene variants in panic patients (Sand, Schlurmann, et al, 2002). The involvement of ovarian hormones in panic is also suggested in a noradrenergic challenge study of isoproterenol, a ␤-adrenoreceptor (␤-AR) agonist.…”

Section: Neurocircuitry and Biochemical Mechanismsmentioning

confidence: 99%

Hot flashes and panic attacks: A comparison of symptomatology, neurobiology, treatment, and a role for cognition.

Hanisch

Hantsoo

Freeman

et al. 2008

Psychological Bulletin

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Despite decades of research, the causal mechanisms of hot flashes are not adequately understood, and a biopsychosocial perspective on hot flashes remains underdeveloped. This article explores overlooked parallels between hot flashes and panic attacks within 5 areas: course and symptomatology, physiological indicators, neurocircuitry and biochemical mechanisms, pharmacotherapy, and psychological treatment, noting both similarities and important differences between the 2 events. An integrative conceptual model is presented that identifies key ways in which psychological factors may influence the experience of hot flashes, with clinical implications and areas of future research. This model yields readily testable hypotheses and may provide a template for exploring the role of cognition in the frequency and severity of hot flashes and, in turn, a basis for the development of nonpharmacological treatments.

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Section: Neurocircuitry and Biochemical Mechanismsmentioning

confidence: 99%

Hot flashes and panic attacks: A comparison of symptomatology, neurobiology, treatment, and a role for cognition.

Hanisch

Hantsoo

Freeman

et al. 2008

Psychological Bulletin

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“…Interestingly, an ESR1 intronic dinucleotide repeat polymorphism was found to be related to anxiety as measured by self-ratings in a cohort of male substance abusers (83). Sand et al (84) found no association between ESR1 gene variants and PD. They stated that this failure to detect an association with respect to ESR1 does not necessarily rule out a participation of other cellular mediators of estrogen effects in promoting vulnerability to this anxiety disorder.…”

Section: Candidate Genesmentioning

confidence: 99%

The genetics of panic disorder: state of the art

West

Claes

2004

Acta Neuropsychiatr.

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Panic disorder (PD) is a highly prevalent, debilitating disorder. The heritability of the disease has been estimated by twin studies to be between 30 and 60%. The vulnerability for PD overlaps with an increased risk of bipolar disorder in some families. Classical genetic methods such as linkage analysis and association studies have not yet identified genetic risk factors beyond doubt. However, two independent studies confirm linkage of a specific syndrome characterized by PD, bladder problems, severe headaches, mitral valve prolapse and thyroid dysfunction to genetic markers on chromosome 13q. Association studies, although showing divergent results, give some support to a causative role for the genes encoding for monoamine oxidase A (MAO-A), cholecystokinin (CCK) and catechol-O-methyltransferase (COMT). Finally, a somatic duplication of a 19-Mb region on chromosome 15 has been associated with PD, but this intriguing finding awaits confirmation.

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Behavioral Genetics of Affective and Anxiety Disorders

Domschke

Reif

2011

Current Topics in Behavioral Neurosciences

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As shown by clinical genetic studies, affective and anxiety disorders are complex genetic disorders with genetic and environmental factors interactively determining their respective pathomechanism. Advances in molecular genetic techniques including linkage studies, association studies, and genome-wide association studies allow for the detailed dissection of the genetic influence on the development of these disorders. Besides the molecular genetic investigation of categorical entities according to standardized diagnostic criteria, intermediate phenotypes comprising neurobiological or neuropsychological traits (e.g., neuronal correlates of emotional processing) that are linked to the disease of interest and that are heritable, have been proposed to be closer to the underlying genotype than the overall disease phenotype. These intermediate phenotypes are dimensional and more precisely defined than the categorical disease phenotype, and therefore have attracted much interest in the genetic investigation of affective and anxiety disorders. Given the complex genetic nature of affective and anxiety disorders with an interaction of multiple risk genes and environmental influences, the interplay of genetic factors with environmental factors is investigated by means of gene-environment interaction (GxE) studies. Pharmacogenetic studies aid in the dissection of the genetically influenced heterogeneity of psychotropic drug response and may contribute to the development of a more individualized treatment of affective and anxiety disorders. Finally, there is some evidence for genetic factors potentially shared between affective and anxiety disorders pointing to a possible overlapping phenotype between anxiety disorders and depression.

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Estrogen receptor 1 gene (ESR1) variants in panic disorder

Cited by 10 publications

References 14 publications

Hot flashes and panic attacks: A comparison of symptomatology, neurobiology, treatment, and a role for cognition.

Hot flashes and panic attacks: A comparison of symptomatology, neurobiology, treatment, and a role for cognition.

The genetics of panic disorder: state of the art

Behavioral Genetics of Affective and Anxiety Disorders

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