Estrogen receptor 1, Glutathione S-transferase P1, Glutathione S-transferase M1, and Glutathione S-transferase T1 Genes with Dysmenorrhea in Korean Female Adolescents

Woo, Hee‐Yeon; Kim, Kye Hyun; Lim, Se-won

doi:10.3343/kjlm.2010.30.1.76

Cited by 5 publications

(1 citation statement)

References 29 publications

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“…In women with infertility and low response to ovarian stimulation genotype AG gene ESR1 was found most frequently [3]. ESR1 gene polymorphism may be associated with the development of dysmenorrhea [12], migraine [7,9], the regulation of behavior and mood of women [8,10].…”

Section: вплив поліморфізму гена рецептора естрогену Esr1 на реалізацію розвитку передменструального синдрому лв пахаренкоmentioning

confidence: 99%

Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrual syndrome

Pakharenko

2020

RHW

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To identify risks of development of any disease is a priority of modern medicine. The aim of this study was to investigate the frequency of polymorphic variants of A-351G gene estrogen receptor ESR1 in patients with various forms of PMS. Molecular genetic analysis of ESR1 gene polymorphism in 50 women with PMS (25 women of them had edematous form of disease, 25 -neuropsychical, 25 -mild, 25 -severe form) was carried out. 25 women without diagnosis of PMS were examined as controls.The study A-351G polymorphism estrogen gene ESR1 showed no statistically significant differences in the frequency of distribution of genotypes and alleles between women with PMS and without this pathology. However, the frequency of GG genotype in women with severe PMS was significantly higher in 8.0 times compared with healthy women (χ 2 =4.87, p=0.03) and in women with edematous form of PMS -in 7.0 times (χ 2 =3.72, p=0.05). Thus, a polymorphic variant of A-351G gene ESR1 estrogen can be considered as a marker of PMS. Pathological variant GG genotype was significantly associated with the presence of edematous and severe forms of the disease.

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confidence: 99%

Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrual syndrome

Pakharenko

2020

RHW

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Study on the enhanced efficacy mechanism of vinegar‐processed Cyperus rotundus in the treatment of primary dysmenorrhea

Wang,

Qian,

Feng

et al. 2024

Biomedical Chromatography

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The enhanced efficacy of vinegar‐processed Cyperus rotundus (VCR) in treating primary dysmenorrhea (PD) has been observed. However, the active components and potential mechanisms of synergy are still unclear. The objective of this study was to develop a method that combines bionic technology, plant metabolomics and network pharmacology to discover the active components and potential mechanisms underlying the enhanced therapeutic effects of VCR for PD. Vinegar processing alters the flavor of C. rotundus, leading to changes in its properties. The acidic nature of vinegar enhances the selectivity of the medicine toward the liver, thereby improving its ability to soothe the liver, regulate qi and provide pain relief. Through gas chromatography–mass spectrometry and multivariate statistical analysis, 30 key differential components between raw C. rotundus and VCR have been screened and identified. These differential components primarily exert their therapeutic effects in treating PD by modulating targets such as interleukin‐6, TNF, TP53 and PTGS2, as well as pathways including the estrogen signaling pathway, ovarian steroidogenesis, the TNF signaling pathway and the HIF‐1 signaling pathway. The findings of this study serve as a reference for the application of VCR in compound formulas and clinic practiceal. Furthermore, the methodology employed in this study provides research insights for the processing of other Chinese medicines.

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A machine‐learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes

Kringel

Lippmann

Parnham

et al. 2018

European Journal of Pain

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BackgroundHuman genetic research has implicated functional variants of more than one hundred genes in the modulation of persisting pain. Artificial intelligence and machine‐learning techniques may combine this knowledge with results of genetic research gathered in any context, which permits the identification of the key biological processes involved in chronic sensitization to pain.MethodsBased on published evidence, a set of 110 genes carrying variants reported to be associated with modulation of the clinical phenotype of persisting pain in eight different clinical settings was submitted to unsupervised machine‐learning aimed at functional clustering. Subsequently, a mathematically supported subset of genes, comprising those most consistently involved in persisting pain, was analysed by means of computational functional genomics in the Gene Ontology knowledgebase.ResultsClustering of genes with evidence for a modulation of persisting pain elucidated a functionally heterogeneous set. The situation cleared when the focus was narrowed to a genetic modulation consistently observed throughout several clinical settings. On this basis, two groups of biological processes, the immune system and nitric oxide signalling, emerged as major players in sensitization to persisting pain, which is biologically highly plausible and in agreement with other lines of pain research.ConclusionsThe present computational functional genomics‐based approach provided a computational systems‐biology perspective on chronic sensitization to pain. Human genetic control of persisting pain points to the immune system as a source of potential future targets for drugs directed against persisting pain. Contemporary machine‐learned methods provide innovative approaches to knowledge discovery from previous evidence.SignificanceWe show that knowledge discovery in genetic databases and contemporary machine‐learned techniques can identify relevant biological processes involved in Persitent pain.

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Estrogen receptor 1, Glutathione S-transferase P1, Glutathione S-transferase M1, and Glutathione S-transferase T1 Genes with Dysmenorrhea in Korean Female Adolescents

Cited by 5 publications

References 29 publications

Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrual syndrome

Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrual syndrome

Study on the enhanced efficacy mechanism of vinegar‐processed Cyperus rotundus in the treatment of primary dysmenorrhea

A machine‐learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes

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