2004
DOI: 10.1210/me.2003-0446
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Estrogen Receptor (ER)-Mediated Transcriptional Regulation of the Human Corticotropin-Releasing Hormone-Binding Protein Promoter: Differential Effects of ERα and ERβ

Abstract: CRH-binding protein (CRH-BP) regulates activation of the hypothalamic-pituitary-adrenal (HPA) axis by binding and inhibiting CRH. We investigated for the first time transcriptional regulation of the human CRH-BP promoter using transient transfections. Estrogen receptors (ERs) contributed to ligand-independent constitutive activation of the promoter, whereas in the presence of estradiol ERalpha induced and ERbeta repressed promoter activity in a dose-dependent manner. TNFalpha inhibited promoter induction by ER… Show more

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Cited by 45 publications
(33 citation statements)
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“…It is not possible to compare our human brain results with rat brain studies, as gender differences in the expression levels of CRF-BP within the rat brain have not been reported. However, in light of published data showing estrogen receptor-dependent regulation of the human CRF-BP gene in vitro (van de Stolpe et al, 2004), it is possible that reproductive hormone differences between males and females may contribute to gender differences in the basal level of CRF-BP expression.…”
Section: Discussionmentioning
confidence: 99%
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“…It is not possible to compare our human brain results with rat brain studies, as gender differences in the expression levels of CRF-BP within the rat brain have not been reported. However, in light of published data showing estrogen receptor-dependent regulation of the human CRF-BP gene in vitro (van de Stolpe et al, 2004), it is possible that reproductive hormone differences between males and females may contribute to gender differences in the basal level of CRF-BP expression.…”
Section: Discussionmentioning
confidence: 99%
“…Because a gender difference was detected in CRF-BP mRNA levels in normals, and since the activity of the human CRF-BP promoter is responsive to estrogen receptors (van de Stolpe et al, 2004), we performed separate nonparametric tests for each gender to determine if there was a significant difference among diagnostic groups in BL CRF-BP mRNA levels. For males, a Kruskal-Wallis H test revealed a significant difference among diagnostic groups (n ¼ 9/ group) in BL CRF-BP mRNA levels (w 2 ¼ 13.01; df ¼ 3; po0.01).…”
Section: Basolateral Amygdalamentioning
confidence: 99%
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“…Additional in vivo studies with chromatin immunoprecipitation will assist in determining whether the estrogen effects observed in vivo are caused by the formation of a transcriptional complex on the Ucn promoter, in its natural chromatin context in different target tissues. Estrogens also differentially regulate stress-related genes such as vasopressin (Shapiro et al, 2000), CRH (Vamvakopoulos and Chrousos, 1993;Ni et al, 2004;Miller et al, 2004), CRH binding protein (Van de Stolpe et al, 2004), and tyrosine hydroxylase (Maharjan et al, 2005). Estrogen receptors differentially regulate the expression of Ucn and CRH in brain regions involved in the stress response based on gender.…”
Section: Discussionmentioning
confidence: 99%
“…Available evidence suggests that gender differences observed in the stress response are caused by estrogen regulation of CRH and CRH-binding protein expression (Miller et al, 2004;Van de Stolpe et al, 2004). Estrogens regulate transcription via a complex and highly regulated process.…”
Section: Introductionmentioning
confidence: 99%