Estrogen receptor-mediated health benefits of phytochemicals: a review

Li, Junfeng; Yu, Jia; Zou, Haoyang; Zhang, Jie; Ren, Li

doi:10.1039/d3fo04702d

Cited by 6 publications

(1 citation statement)

References 120 publications

(144 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, since both natural and synthetic phytoestrogens have some limitations in disease treatment, a combined therapy using both could result in a higher efficacy of synthetic drugs. Nowadays, numerous phytochemicals such as flavones, isoflavones, flavonoids, polyphenols, phenolic acids, lignans, tannins, stilbenes, coumarins, sterols, and terpenoids have been pointed out as pure ERs agonists, as partial agonists, or as pure antagonists [129].…”

Section: Phytoestrogens In Head and Neck Tumor Prevention Treatment A...mentioning

confidence: 99%

The Role of Estrogen and Estrogen Receptors in Head and Neck Tumors

Kranjčević,

Čonkaš,

Ozretić

2024

Cancers

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC) is the most common histological form of head and neck tumors (HNTs), which originate from the epithelium of the lips and oral cavity, pharynx, larynx, salivary glands, nasal cavity, and sinuses. The main risk factors include consumption of tobacco in all forms and alcohol, as well as infections with high-risk human papillomaviruses or the Epstein–Barr virus. Regardless of the etiological agent, the risk of developing different types of HNTs is from two to more than six times higher in males than in females. The reason for such disparities probably lies in a combination of both biological and psychosocial factors. Therefore, it is hypothesized that exposure to female sex hormones, primarily estrogen, provides women with protection against the formation and metastasis of HNTs. In this review, we synthesized available knowledge on the role of estrogen and estrogen receptors (ERs) in the development and progression of HNTs, with special emphasis on membrane ERs, which are much less studied. We can summarize that in addition to epidemiologic studies unequivocally pointing to the protective effect of estrogen in women, an increased expression of both nuclear ERs, ERα, and ERβ, and membrane ERs, ERα36, GPER1, and NaV1.2, was present in different types of HNSCC, for which anti-estrogens could be used as an effective therapeutic approach.

show abstract

Section: Phytoestrogens In Head and Neck Tumor Prevention Treatment A...mentioning

confidence: 99%