2013
DOI: 10.1016/j.mce.2013.05.016
|View full text |Cite
|
Sign up to set email alerts
|

Estrogen receptor α and β in the normal immune system and in lymphoid malignancies

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
88
0
2

Year Published

2014
2014
2023
2023

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 91 publications
(92 citation statements)
references
References 143 publications
2
88
0
2
Order By: Relevance
“…An alternative hypothesis to our observation in women with CLL may involve the aromatization of testosterone to estradiol, an efficient agonist for ERβ, which is the main ER expressed in lymphoid tissues also overexpressed in CLL [11, 15, 35]. Accordingly, the improved TFS in female cases may be, at least in part, the consequence of a greater local exposure of leukemic cells to estrogens, described as tumor-suppressive molecules acting via the ER axis in cells of lymphoid origin that express ERβ [36].…”
Section: Discussionmentioning
confidence: 96%
“…An alternative hypothesis to our observation in women with CLL may involve the aromatization of testosterone to estradiol, an efficient agonist for ERβ, which is the main ER expressed in lymphoid tissues also overexpressed in CLL [11, 15, 35]. Accordingly, the improved TFS in female cases may be, at least in part, the consequence of a greater local exposure of leukemic cells to estrogens, described as tumor-suppressive molecules acting via the ER axis in cells of lymphoid origin that express ERβ [36].…”
Section: Discussionmentioning
confidence: 96%
“…The expression of ER-β is mainly found in prostate, kidney, bladder, lung, bones, circulatory system including heart, endothelial cells and blood cells, thymus and intestines (Kuiper et al, 1996;van Pelt et al, 1999). ER-β is closely relates to inflammation (Yakimchuk et al, 2013). The biological function of isoflavones also depends on endogenous estradiol levels.…”
Section: Hormone-like Propertiesmentioning
confidence: 99%
“…[5][6][7] Estrogen receptors (both alpha and beta) are expressed on normal B and T lymphocytes, bone marrow, and in leukemia and lymphoma cell lines. 7,8 A consistent clinical observation is that women develop autoimmune diseases much more frequently than men. 7,9,10 Furthermore, epidemiologic studies have demonstrated that a history of autoimmune diseases is a significant risk for the subsequent development of lymphoma and multiple myeloma.…”
mentioning
confidence: 90%