2007
DOI: 10.1016/j.cca.2007.04.003
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Estrogen receptor α (ESR1) PvuII and XbaI gene polymorphisms in ischemic stroke in a Hungarian population

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Cited by 25 publications
(19 citation statements)
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“…9 Moreover, there are conflicting results about the impact of these polymorphisms on the risk of stroke. 15,16 Intimal-medial thickening (IMT) of the carotid artery is a quantitative measure of atherosclerosis assessed by B-mode ultrasonography. Although it is the most commonly assessed ultrasonographic carotid measurement because of its high measurement precision and its graded and predictive relationship to overt clinical disease, 17 Data are presented as n (%).…”
Section: Discussionmentioning
confidence: 99%
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“…9 Moreover, there are conflicting results about the impact of these polymorphisms on the risk of stroke. 15,16 Intimal-medial thickening (IMT) of the carotid artery is a quantitative measure of atherosclerosis assessed by B-mode ultrasonography. Although it is the most commonly assessed ultrasonographic carotid measurement because of its high measurement precision and its graded and predictive relationship to overt clinical disease, 17 Data are presented as n (%).…”
Section: Discussionmentioning
confidence: 99%
“…16 The presence of PvuII and XbaI polymorphisms within the ESR gene were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The oligonucleotide primers used to determine the PvuII and XbaI polymorphisms included forward primer, 5'-CTG CCA CCC TAT CTG TAT CTT TTC CTA TTC TCC-3'; and reverse primer, 5'-TCT TTC TCT GCC ACC CTG GCG TCG ATT ATC TGA-3'.…”
Section: Determination Of Esr1 Genotypesmentioning
confidence: 99%
“…The sequence of primers, as well as the conditions for amplification and genotyping of PvuII and XbaI polymorphisms, followed the technique previously described (Molvarec et al, 2007b). Briefly, 50 ng genomic DNA was added to PCR buffer, containing 2 mM MgCl 2 , 0.2 U Taq DNA polymerase (Thermo), 0.2 mM dNTP (Thermo) mix and 1 μM forward and reverse primers (IDT).…”
Section: Genotypingmentioning
confidence: 99%
“…These polymorphisms have been associated with male and female infertility, breast cancer, osteoporosis, Alzheimer's disease, cardiovascular diseases, hemostatic abnormalities, preeclampsia, increased abdominal circumference, systemic lupus erythematosus, T2DM, age at menarche, and the onset of menopause (Corbo et al, 2011;Molvarec et al, 2007b;Weel et al, 1999;Schuit et al, 2005;Huang et al, 2006;Stavrou et al, 2006;Lu et al, 2009). A possible functional mechanism attributed to the polymorphisms of the ESR1 gene includes a change in mRNA processing, producing different variants or isoforms of the protein.…”
Section: Introductionmentioning
confidence: 97%
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