Estrogen receptor α gene polymorphisms and anxiety disorder in an elderly population

Tiemeier, Henning; Schuit, Stephanie C. E.; Heijer, Torn Den; Meurs, Joyce B. J. van; Tuijl, H. Ruud van; Hofman, Albert; Breteler, Monique M.B.; Pols, Huibert A. P.; Uitterlinden, André G.

doi:10.1038/sj.mp.4001697

Cited by 40 publications

(42 citation statements)

References 11 publications

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“…A significant association was observed between depression and two distinct single-nucleotide polymorphisms of ERα in women with major depression but not in men [135,136]. ER polymorphisms may also be involved in HT response, a possibility which has not yet been evaluated.…”

Section: Is There a Common Pattern Of Vulnerability Regarding Reprodumentioning

confidence: 88%

Hormonal therapy and depression: Are we overlooking an important therapeutic alternative?

Ancelin¹,

Scali²,

Ritchie³

2007

Journal of Psychosomatic Research

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implications: that women vary in vulnerability to mood disorder when abrupt change in steroid levels occur, that these effects could be cumulative across the female lifespan, and that women do not arrive at menopause with equal risk of mood disorders, or equal susceptibility to the effects of hormonal replacement therapy as has been assumed by current clinical research and practice. Conclusion:While hormonal therapies could have positive effects in the treatment and prevention of depressive disorders, further research is required to differentiate hormone-responsive subgroups of women for whom specific hormonal treatments may be most beneficial. To this end we suggest that a multifactorial model of cumulative vulnerability, which takes into account hormonal exposure throughout life, genetic vulnerability and environmental factors, may provide better prediction of treatment response.

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Section: Is There a Common Pattern Of Vulnerability Regarding Reprodumentioning

confidence: 88%

Hormonal therapy and depression: Are we overlooking an important therapeutic alternative?

Ancelin¹,

Scali²,

Ritchie³

2007

Journal of Psychosomatic Research

View full text Add to dashboard Cite

show abstract

“…The G and C alleles respectively have been associated with higher gene expression (Alonso et al, 2011), and increased serum estrogen levels Sowers et al, 2006), although not consistently (Malacara et al, 2004;Yaffe et al, 2009). In a similar manner, one or both alleles have also been associated with more favourable estrogen-dependent outcomes such as higher bone mass density and lower fractures (Ioannidis et al, 2002)), and a decreased risk of cognitive impairment (Yaffe et al, 2002), Alzheimer's disease (Monastero et al, 2006), phobia (Ryan et al, 2011b), general anxiety (Tiemeier et al, 2005) and cardiovascular disease . On the other hand, other studies have also reported both null (den Heijer et al, 2004;Koch et al, 2005;Silvestri et al, 2006) and reverse findings (Brandi et al, 1999;Shearman et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Estrogen receptor alpha gene variants and major depressive episodes

Ryan

Scali

Carrière

et al. 2012

Journal of Affective Disorders

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Background: Despite evidence of estrogen's mood-enhancing effects, the association between estrogen receptor (ER) gene variants and lifetime major depression has been insufficiently studied.Methods: 3987 community-dwelling women aged 65 years and over were recruited in France as part of the Three City Study. Current and past major depressive disorders (MDD) were diagnosed using the Mini-International Neuropsychiatry Interview, according to DSM-IV criteria. The association between two common estrogen receptor alpha (ESR1) polymorphisms with lifetime MDD was examined using adjusted logistic regression models, taking into account the age at first depressive episode and the recurrence of depression.Results: Women homozygous for the variant G allele of ESR1 rs9340799 had a 1.6-fold increased risk of MDD across their lifetime compared with women who were homozygous for the A allele (p=0.009). There was a similar non-significant trend for the C allele of rs2234693 being associated with an increased risk (p=0.09). Polytomous regression analysis further indicated that the GG genotype of rs9340799 was specifically associated with an increased risk of recurrent depressive episodes, regardless of the age at first onset of depression relative to the menopause. Limitations:The duration and severity of depressive episodes was not considered in the analysis.Conclusions: This is the first study to examine the association between ESR1 gene variants and lifetime MDD. Our findings indicate a significant association between common variants and the risk of recurrent depressive episodes. This suggests that certain depressed women could be most responsive to hormone-based treatment.

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“…Genetic variation in the ER may therefore influence a person's risk of developing anxiety, but this has been insufficiently studied. The Rotterdam study of 1335 women aged over 55 years, found a significant association between ESR1 polymorphisms (rs2234693 and rs9340799) and global anxiety level (Tiemeier et al, 2005), but no subsequent study has attempted to replicate these findings or to examine whether this could vary across anxiety disorders. We report here that in older women these same ESR1 gene variants were specifically associated with the risk of phobia, but current HT use could modify this association.…”

Section: Discussionmentioning

confidence: 99%

“…A study of children and adolescents reported an association between ESR1 gene variants and anxiety-related traits (Prichard et al, 2002), and ESR1 variants were recently associated with contamination obsessions and cleaning compulsions in young adult patients with obsessive-compulsive disorder (Alonso et al, 2011). In terms of late-life anxiety, the Rotterdam study reported that ESR1 haplotypes consisting of the T and A alleles of rs2234693 and 5 rs9340799 respectively were associated with an increased risk of global anxiety level in 1335 older women (Tiemeier et al, 2005), however, to our knowledge, no subsequent study has sought to replicate these findings. Furthermore, prior studies have not examined ESR2, although evidence in mice suggests that ESR2 may be particularly important in modulating anxiety-like behavior (Walf and Frye, 2006).…”

Section: Introductionmentioning

confidence: 99%

Estrogen receptor gene variants are associated with anxiety disorders in older women

Ryan

Scali

Carrière

et al. 2011

Psychoneuroendocrinology

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Estrogen receptor α gene polymorphisms and anxiety disorder in an elderly population

Cited by 40 publications

References 11 publications

Hormonal therapy and depression: Are we overlooking an important therapeutic alternative?

Hormonal therapy and depression: Are we overlooking an important therapeutic alternative?

Estrogen receptor alpha gene variants and major depressive episodes

Estrogen receptor gene variants are associated with anxiety disorders in older women

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