Estrogen receptor α genetic variants and the risk of stroke in a South Indian population from Andhra Pradesh

Munshi, Anjana; Sharma, Vandana; Kaul, Subhash; Al-Hazzani, Amal A.; Alshatwi, Ali A.; Manohar, Vishnu; Rajeshwar, K.; Babu, M. Sai; Jyothy, A.

doi:10.1016/j.cca.2010.08.001

Cited by 23 publications

(12 citation statements)

References 39 publications

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“…Stroke is a multifactorial disorder influenced by genetic and environmental factors [1][2][3][4][5][6][7][8]. Evidence suggests that variations in the lipoprotein lipase gene may influence stroke risk [9].…”

Section: Introductionmentioning

confidence: 99%

Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes

Munshi

Babu

Kaul

et al. 2012

Journal of the Neurological Sciences

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Section: Introductionmentioning

confidence: 99%

Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes

Munshi

Babu

Kaul

et al. 2012

Journal of the Neurological Sciences

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“…Homozygous or heterozygous variants were completely absent in all individuals studied and with only the wild type genotype being expressed an OR for risk was not estimable. One relevant study was identified for genes variants IL-1α (C889T) [45], CYP11B2 (C344T) [46], ESR1 (PVUII and XbaI) [47], α ADD1 (WG) [33], TNF α (G488A and G308A) [48], CYP4F2 (G1347A) [49], MDR-1 [50], t-PA (C7351T and I/D) [51], PAI-1 (4G/5G) [51], CBS (T833C) [52], Klotho (KL-VS and C1818T) [53], Factor XIIIB (V34L) [54], α1 antichymotrypsin (Ala15Thr) [55] and MMP3 (5A/6A) [48]. Of these IL-1α, CYP11B2, ESR1 (PVUII), α ADD1, TNF α (G488A), CYP4F2, MDR-1 and t-PA (I/D) were found to be significantly associated with ischemic stroke (Table S1).…”

Section: Resultsmentioning

confidence: 99%

Detailed Analysis of Gene Polymorphisms Associated with Ischemic Stroke in South Asians

et al. 2013

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The burden of stroke is disproportionately high in the South Asian subcontinent with South Asian ethnicity conferring a greater risk of ischemic stroke than European ancestry regardless of country inhabited. While genes associated with stroke in European populations have been investigated, they remain largely unknown in South Asians. We conducted a comprehensive meta-analysis of known genetic polymorphisms associated with South Asian ischemic stroke, and compared effect size of the MTHFR C677T-stroke association with effect sizes predicted from homocysteine-stroke association. Electronic databases were searched up to August 2012 for published case control studies investigating genetic polymorphisms associated with ischemic stroke in South Asians. Pooled odds ratios (OR) for each gene-disease association were calculated using a random-effects model. We identified 26 studies (approximately 2529 stroke cases and 2881 controls) interrogating 33 independent genetic polymorphisms in 22 genes. Ten studies described MTHFR C677T (108 with TT genotype and 2018 with CC genotype) -homocysteine relationship and six studies (735 stroke cases and 713 controls) described homocysteine-ischemic stroke relationship. Risk association ORs were calculated for ACE I/D (OR 5.00; 95% CI, 1.17–21.37; p = 0.03), PDE4D SNP 83 (OR 2.20; 95% CI 1.21–3.99; p = 0.01), PDE4D SNP 32 (OR 1.57; 95% CI 1.01–2.45, p = 0.045) and IL10 G1082A (OR 1.44; 95% CI, 1.09–1.91, p = 0.01). Significant association was observed between elevated plasma homocysteine levels and MTHFR/677 TT genotypes in healthy South Asians (Mean difference (ΔX) 5.18 µmol/L; 95% CI 2.03–8.34: p = 0.001). Our results demonstrate that the genetic etiology of ischemic stroke in South Asians is broadly similar to the risk conferred in Europeans, although the dataset is considerably smaller and warrants the same clinical considerations for risk profiling.

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“…Further, we evaluated the association of this polymorphism with stroke subtypes and found significant association of PvuII polymorphism with extracranial atherosclerosis, lacunar and cardioembolic stroke classified according to the TOAST classification. [30] Genes Involved in Renin-angiotensinaldosterone System…”

Section: Genetic Variants Affecting Coagulation and Fibrinolytic Cascadementioning

confidence: 99%

Genetics of ischemic stroke

Kaul

Munshi

2012

Neurology India

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Estrogen receptor α genetic variants and the risk of stroke in a South Indian population from Andhra Pradesh

Cited by 23 publications

References 39 publications

Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes

Association of LPL gene variant and LDL, HDL, VLDL cholesterol and triglyceride levels with ischemic stroke and its subtypes

Detailed Analysis of Gene Polymorphisms Associated with Ischemic Stroke in South Asians

Genetics of ischemic stroke

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