Estrogen receptor β activation alleviates inflammatory bowel disease by suppressing NLRP3-dependent IL-1β production in macrophages via downregulation of intracellular calcium level

Zhu, Yanrong; Guo, Yilei; Guo, Pengxiang; Zhang, Jing; He, Yue; Xia, Yufeng; Wei, Zhifeng; Dai, Yue

doi:10.1016/j.jare.2024.06.004

Journal of Advanced Research

2024

DOI: 10.1016/j.jare.2024.06.004

|View full text |Cite

Estrogen receptor β activation alleviates inflammatory bowel disease by suppressing NLRP3-dependent IL-1β production in macrophages via downregulation of intracellular calcium level

Yanrong Zhu,

Yilei Guo,

Pengxiang Guo

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Alleviation of Antarctic krill oil on dextran sulfate sodium exposure induced chronic ulcerative colitis and depressive-like behavior

He,

Li,

Zhou

et al. 2024

Journal of Functional Foods

View full text Add to dashboard Cite

Alleviation of Antarctic krill oil on dextran sulfate sodium exposure induced chronic ulcerative colitis and depressive-like behavior

He,

Li,

Zhou

et al. 2024

Journal of Functional Foods

View full text Add to dashboard Cite

Diallyl trisulfide alleviates dextran sulphate sodium‐induced colitis in mice by inhibiting NLRP3 inflammasome activation via ROS/Trx‐1 pathway

He,

Xiao,

Zhang

et al. 2024

Basic Clin Pharma Tox

View full text Add to dashboard Cite

Diallyl trisulfide (DATS), a sulphur‐containing compound isolated from the medicinal food plant garlic, has been previously reported to attenuate experimental colitis induced by either dextran sodium sulphate (DSS) or 2,4,6‐trinitrobenzenesulfonic acid (TNBS) in mice; however, the underlying mechanism remains to be identified. In this study, we deciphered the key mechanism by which DATS alleviates ulcerative colitis (UC). We showed that oral administration of DATS for 10 consecutive days greatly restrained the infiltration of macrophages and the pathological changes in colonic tissues of mice with DSS‐induced colitis. DATS treatment notably dampened the content of IL‐1β and IL‐18 and suppressed NLRP3 inflammasome activation in colon. Mechanistically, DATS effectively diminished the generation of ROS in macrophages. The suppressive effect of DATS on the activation of NLRP3 inflammasome and downregulation of IL‐18 and IL‐1β levels was blunted by xanthine oxidase. Further studies revealed that DATS inhibited NF‐κB pathway activation by suppressing the expression of Trx‐1, thereby inhibiting NLRP3 inflammasome activation. Trx‐1 overexpression and interference in macrophages promoted and diminished NLRP3 inflammasome activation, respectively. In summary, garlic and its main active ingredient DATS have potentials to prevent and treat UC, and DATS functions by inhibiting NLRP3 inflammasome activation via Trx‐1/ROS pathway.

show abstract

The Role of Estrogen across Multiple Disease Mechanisms

Xiang,

Palasuberniam,

Pare

2024

CIMB

View full text Add to dashboard Cite

Estrogen is a significant hormone that is involved in a multitude of physiological and pathological processes. In addition to its pivotal role in the reproductive system, estrogen is also implicated in the pathogenesis of a multitude of diseases. Nevertheless, previous research on the role of estrogen in a multitude of diseases, including Alzheimer’s disease, depression, cardiovascular disease, diabetes, osteoporosis, gastrointestinal diseases, and estrogen-dependent cancers, has concentrated on a single disease area, resulting in a lack of comprehensive understanding of cross-disease mechanisms. This has brought some challenges to the current treatment methods for these diseases, because estrogen as a potential therapeutic tool has not yet fully developed its potential. Therefore, this review aims to comprehensively explore the mechanism of estrogen in these seven types of diseases. The objective of this study is to describe the relationship between each disease and estrogen, including the ways in which estrogen participates in regulating disease mechanisms, and to outline the efficacy of estrogen in treating these diseases in clinical practice. By studying the role of estrogen in a variety of disease mechanisms, it is hoped that a more accurate theoretical basis and clinical guidance for future treatment strategies will be provided, thus promoting the effective management and treatment of these diseases.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Estrogen receptor β activation alleviates inflammatory bowel disease by suppressing NLRP3-dependent IL-1β production in macrophages via downregulation of intracellular calcium level

Cited by 3 publications

References 60 publications

Alleviation of Antarctic krill oil on dextran sulfate sodium exposure induced chronic ulcerative colitis and depressive-like behavior

Alleviation of Antarctic krill oil on dextran sulfate sodium exposure induced chronic ulcerative colitis and depressive-like behavior

Diallyl trisulfide alleviates dextran sulphate sodium‐induced colitis in mice by inhibiting NLRP3 inflammasome activation via ROS/Trx‐1 pathway

The Role of Estrogen across Multiple Disease Mechanisms

Contact Info

Product

Resources

About