Estrogen receptors and their downstream targets in cancer

Ikeda, Kazuhiro; Inoue, Satoshi

doi:10.1679/aohc.67.435

Cited by 57 publications

(41 citation statements)

References 38 publications

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“…ERα is believed to regulate expression of genes involved in cell survival and proliferation, thus promoting tumor growth and differentiation, while the function of ERβ has been found to be anti-proliferative and pro-apoptotic. [20][21][22][23] ERβ has several splicing variants, including ERβ1 (wild type), ERβ2 (identical to ERβcx), ERβ3, ERβ4, ERβ5, and ERΔ5. 24,25 Interestingly, ERβ1 has been shown to act as a tumor suppressor, 26 and its expression declines during breast cancer progression.…”

Section: Lapatinib Induces P27mentioning

confidence: 99%

Lapatinib induces p27^Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms

et al. 2013

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Section: Lapatinib Induces P27mentioning

confidence: 99%

Lapatinib induces p27^Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms

et al. 2013

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“…Estrogens induce the proliferation of normal and neoplastic cells expressing estrogen receptors (ER) by both genomic and non-genomic pathways where multiple signalling transduction pathways are involved [1][2][3]. In different types of cancer, estrogens synergize the effects of growth factors by acting at both receptor and post-receptor levels and, doing so, favour the growth, proliferation and spreading of tumour mass [4][5].…”

Section: Introductionmentioning

confidence: 99%

Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor

Mancino

Glaser

et al. 2009

Digestive and Liver Disease

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Background-Estrogens may induce the proliferation of neoplastic cells by activating neoangiogenesis.Aim-To evaluate the effect of estrogens on the expression of vascular endothelial growth factor (VEGF) and related receptors (VEGF-R) in human cholangiocarcinoma and the role played by VEGF in mediating the proliferative effects of estrogens.Methods-Seven biopsies of intra-hepatic cholangiocarcinoma and the HuH-28 cell lines were investigated. Cell proliferation was measured by both PCNA Western blot and MTS proliferation assay.Results-By immunohistochemistry, biopsies of human cholangiocarcinoma stained positively for VEGF-A and VEGF-C and related receptors. HuH-28 cells expressed VEGF-A, -C, and VEGFR-1, -2, -3 and, their protein level was enhanced by 17β-estradiol in association with the stimulation of cell proliferation. 17β-Estradiol-stimulated proliferationof HuH-28 cells was blocked by 70% by VEGF-trap, a receptor-based VEGF inhibitor. 17β-Estradiol induced the secretion of VEGF in the

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“…The presence of nerve fibers containing VIP in the female reproductive organs is known (Owman and Stjernquist 2003), however, there was no interest in the distribution of VIP receptors in these organs. More attention was paid to the receptors for sex steroids and gonadotropins (Ikeda and Inoue 2004). There is lack of studies which systematically investigate the distribution of VIP receptors in the female reproductive organs.…”

Section: Discussionmentioning

confidence: 99%

Expression of VPAC1 receptor at the level of mRNA and protein in the porcine female reproductive system

Bukowski¹,

Wąsowicz²

2015

Polish Journal of Veterinary Sciences

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The presence and distribution of vasoactive intestinal polypeptide (VIP) receptor VPAC1 was studied in the ovary, oviduct and uterus (uterine horn and cervix) of the domestic pig using methods of molecular biology (RT-PCR and immunoblot) and immunohistochemistry.The expression of VPAC1 receptor at mRNA level was confirmed with RT-PCR in all the studied parts of the porcine female reproductive system by the presence of 525 bp PCR product and at the level of proteins by the detection of 46 kDa protein band in immunoblot. Immunohistochemical stainings revealed the cellular distribution of VPAC1 receptor protein. In the ovary it was present in the wall of arterial blood vessels, as well as in the ovarian follicles of different stages. In the tubular organs the VPAC1 receptor immunohistochemical stainings were observed in the wall of the arterial blood vessels, in the muscular membrane, as well as in the mucosal epithelium.The study confirmed the presence of VPAC1 receptor in the tissues of the porcine female reproductive tract what clearly shows the possibility of influence of VIP on the porcine ovary, oviduct and uterus.

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Estrogen receptors and their downstream targets in cancer

Cited by 57 publications

References 38 publications

Lapatinib induces p27^Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms

Lapatinib induces p27^Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms

Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor

Expression of VPAC1 receptor at the level of mRNA and protein in the porcine female reproductive system

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Estrogen receptors and their downstream targets in cancer

Cited by 57 publications

References 38 publications

Lapatinib induces p27Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms

Lapatinib induces p27Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms

Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor

Expression of VPAC1 receptor at the level of mRNA and protein in the porcine female reproductive system

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Lapatinib induces p27^Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms

Lapatinib induces p27^Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms