Estrogen Receptors in Colorectal Adenocarcinomas and in Other Large Bowel Diseases

Sciascia, C; Olivero, G; Comandone, Alessandro; Festa, T; Mg, Fiori; Enrichens, F

doi:10.1177/172460089000500108

Cited by 8 publications

(4 citation statements)

References 16 publications

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“…Some experimental results indicated that estrogen had a trophic effect on colon cancer [1,[11][12] . However, the effect of estrogen on colon cancer is controversial according to some reports.…”

Section: Discussionmentioning

confidence: 99%

“…According to some published reports, ERα was also present in gastric or colon cancer [11][12][13][14][15][16][17][18] . Our results support this conclusion.…”

Section: Discussionmentioning

confidence: 99%

“…However, the physiological significance of these ERβ isoforms is still unknown. Meanwhile, published data about the expression of ERα and ERβ in colon cancer tissues were often controversial [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] . Therefore it is reasonable to reevaluate ER status and hormonal modulation of cell growth in colon cancer.…”

Section: Introductionmentioning

confidence: 99%

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Expression of estrogen receptor ® in human colorectal cancer

Xie¹,

Yu²,

Luo³

2004

WJG

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Section: Discussionmentioning

confidence: 99%

“…According to some published reports, ERα was also present in gastric or colon cancer [11][12][13][14][15][16][17][18] . Our results support this conclusion.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of estrogen receptor ® in human colorectal cancer

Xie¹,

Yu²,

Luo³

2004

WJG

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“…Immunohistochemistry may be of confusion, as CDX2 may be expressed both in endometrioid and mucinous endometrial carcinoma, and ER can occasionally be expressed in colon cancers [12]. PAX8 may help exclude the Mullerian origin; while p16 immunostaining which may help to unmask an endocervical primary, was positive in our case.…”

Section: Discussionmentioning

confidence: 67%

Endometrium-limited Metastasis From Colon Carcinoma

Pecorella

Tucci

Rullo

et al. 2021

Multidiscip Cancer Investig

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Introduction: Extragenital tumors uncommonly affect the female genital tract and usually involve the ovaries (75-80%), while the uterus can harbor metastases in the context of a widely disseminated disease. The primary tumors are most often located in the breast (35%) or gastrointestinal tract (38%). Metastases to the uterine body usually involve the myometrium whereas those exclusively involving the endometrium are rare. Case presentation: We report the case of a 50-year-old woman with endometrial metastasis from a colonic adenocarcinoma 6 years after the initial presentation. Conclusion: Metastatic colon tumors can histologically present as a primary disease in the endometrium if the pathologist has little awareness to consider metastasis. The clinical history of disseminated metastases, the lack of CK7 expression at immunohistochemistry, and positive results for CK20 and nuclear CDX2 are helpful clues to support the diagnosis of metastatic carcinoma of colorectal origin.

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Oestrogen and progesterone receptors in colorectal cancer and human colonic cancer cell lines

Hendrickse

Jones

Donovan

et al. 1993

Journal of British Surgery

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Receptors for oestrogen (ER) and progesterone (PR) were assayed in tissue from 17 patients with colorectal cancer and five colonic cancer cell lines using enzyme immunoassays. ERs and PRs were detected in 15 and 17 cancers respectively, although the levels detected were low: median (range) ER 1.3 (0-11.3) and PR 3.9 (0.3-10.2) fmol per mg protein. These values were not significantly different from median (range) levels of ER (1.1 (0.6-3.0) fmol/mg) and PR (1.9 (0.5-3.2) fmol/mg) detected in normal mucosa. There were significant positive correlations between the levels of ER and PR for cancer tissue (tau = 0.56, P < 0.005; r(log transform) = 0.68, P < 0.003; n = 17) but not for mucosa, and between levels of ER in cancer tissue and mucosa (tau = 0.55, P < 0.05; r(log transform) = 0.70, P < 0.025; n = 10) but not between the corresponding PR values. In maintenance media, which contained phenol red and unstripped fetal calf serum, the median (range) concentration of ER was 1.9 (1.2-10.4) fmol/mg and that for PR 24.3 (9.1-63.2) fmol/mg in the five cell lines studied (HT-29, LS174T, SW620, LoVo, COLO 320DM). The addition of oestradiol (10 nmol/l) to phenol red-free medium containing 5 per cent dextran-coated charcoal-treated fetal calf serum had little effect on the concentration of ERs or PRs in SW620, LoVo and COLO 320DM cells after 7 days' culture. It is concluded that ERs and PRs are expressed in malignant and normal colonic mucosa. ERs appear to be a feature of the colonic mucosa rather than the malignant process, but in carcinoma may regulate synthesis of PRs, suggesting a degree of oestrogen responsiveness.

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Estrogen Receptors in Colorectal Adenocarcinomas and in Other Large Bowel Diseases

Cited by 8 publications

References 16 publications

Expression of estrogen receptor ® in human colorectal cancer

Expression of estrogen receptor ® in human colorectal cancer

Endometrium-limited Metastasis From Colon Carcinoma

Oestrogen and progesterone receptors in colorectal cancer and human colonic cancer cell lines

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